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Gasdermin-E mediates mitochondrial damage in axons and neurodegeneration.
Neel DV, Basu H, Gunner G, Bergstresser MD, Giadone RM, Chung H, Miao R, Chou V, Brody E, Jiang X, Lee E, Watts ME, Marques C, Held A, Wainger B, Lagier-Tourenne C, Zhang YJ, Petrucelli L, Young-Pearse TL, Chen-Plotkin AS, Rubin LL, Lieberman J, Chiu IM. Neel DV, et al. Among authors: zhang yj. Neuron. 2023 Apr 19;111(8):1222-1240.e9. doi: 10.1016/j.neuron.2023.02.019. Epub 2023 Mar 13. Neuron. 2023. PMID: 36917977
TDP-43 in neurodegenerative disorders.
Cook C, Zhang YJ, Xu YF, Dickson DW, Petrucelli L. Cook C, et al. Among authors: zhang yj. Expert Opin Biol Ther. 2008 Jul;8(7):969-78. doi: 10.1517/14712598.8.7.969. Expert Opin Biol Ther. 2008. PMID: 18549326 Free PMC article. Review.
Aberrant cleavage of TDP-43 enhances aggregation and cellular toxicity.
Zhang YJ, Xu YF, Cook C, Gendron TF, Roettges P, Link CD, Lin WL, Tong J, Castanedes-Casey M, Ash P, Gass J, Rangachari V, Buratti E, Baralle F, Golde TE, Dickson DW, Petrucelli L. Zhang YJ, et al. Proc Natl Acad Sci U S A. 2009 May 5;106(18):7607-12. doi: 10.1073/pnas.0900688106. Epub 2009 Apr 21. Proc Natl Acad Sci U S A. 2009. PMID: 19383787 Free PMC article.
Neurotoxic effects of TDP-43 overexpression in C. elegans.
Ash PE, Zhang YJ, Roberts CM, Saldi T, Hutter H, Buratti E, Petrucelli L, Link CD. Ash PE, et al. Among authors: zhang yj. Hum Mol Genet. 2010 Aug 15;19(16):3206-18. doi: 10.1093/hmg/ddq230. Epub 2010 Jun 8. Hum Mol Genet. 2010. PMID: 20530643 Free PMC article.
Wild-type human TDP-43 expression causes TDP-43 phosphorylation, mitochondrial aggregation, motor deficits, and early mortality in transgenic mice.
Xu YF, Gendron TF, Zhang YJ, Lin WL, D'Alton S, Sheng H, Casey MC, Tong J, Knight J, Yu X, Rademakers R, Boylan K, Hutton M, McGowan E, Dickson DW, Lewis J, Petrucelli L. Xu YF, et al. Among authors: zhang yj. J Neurosci. 2010 Aug 11;30(32):10851-9. doi: 10.1523/JNEUROSCI.1630-10.2010. J Neurosci. 2010. PMID: 20702714 Free PMC article.
Neuronal sensitivity to TDP-43 overexpression is dependent on timing of induction.
Cannon A, Yang B, Knight J, Farnham IM, Zhang Y, Wuertzer CA, D'Alton S, Lin WL, Castanedes-Casey M, Rousseau L, Scott B, Jurasic M, Howard J, Yu X, Bailey R, Sarkisian MR, Dickson DW, Petrucelli L, Lewis J. Cannon A, et al. Acta Neuropathol. 2012 Jun;123(6):807-23. doi: 10.1007/s00401-012-0979-3. Epub 2012 Apr 27. Acta Neuropathol. 2012. PMID: 22539017 Free PMC article.
3,486 results