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Triphenylphosphine oxide is a potent and selective inhibitor of the transient receptor potential melastatin-5 ion channel.
Palmer RK, Atwal K, Bakaj I, Carlucci-Derbyshire S, Buber MT, Cerne R, Cortés RY, Devantier HR, Jorgensen V, Pawlyk A, Lee SP, Sprous DG, Zhang Z, Bryant R. Palmer RK, et al. Among authors: Zhang Z. Assay Drug Dev Technol. 2010 Dec;8(6):703-13. doi: 10.1089/adt.2010.0334. Assay Drug Dev Technol. 2010. PMID: 21158685
TRPM7 is regulated by halides through its kinase domain.
Yu H, Zhang Z, Lis A, Penner R, Fleig A. Yu H, et al. Among authors: Zhang Z. Cell Mol Life Sci. 2013 Aug;70(15):2757-71. doi: 10.1007/s00018-013-1284-6. Epub 2013 Mar 8. Cell Mol Life Sci. 2013. PMID: 23471296 Free PMC article.
Inhibition of TRPM7 suppresses cell proliferation of colon adenocarcinoma in vitro and induces hypomagnesemia in vivo without affecting azoxymethane-induced early colon cancer in mice.
Huang J, Furuya H, Faouzi M, Zhang Z, Monteilh-Zoller M, Kawabata KG, Horgen FD, Kawamori T, Penner R, Fleig A. Huang J, et al. Among authors: Zhang Z. Cell Commun Signal. 2017 Aug 15;15(1):30. doi: 10.1186/s12964-017-0187-9. Cell Commun Signal. 2017. PMID: 28810912 Free PMC article.
Regulation of gene transcription by voltage-gated L-type calcium channel, Cav1.3.
Lu L, Sirish P, Zhang Z, Woltz RL, Li N, Timofeyev V, Knowlton AA, Zhang XD, Yamoah EN, Chiamvimonvat N. Lu L, et al. Among authors: Zhang Z, Zhang XD. J Biol Chem. 2015 Feb 20;290(8):4663-76. doi: 10.1074/jbc.M114.586883. Epub 2014 Dec 23. J Biol Chem. 2015. PMID: 25538241 Free PMC article.
TRPM7-mediated Ca2+ signals confer fibrogenesis in human atrial fibrillation.
Du J, Xie J, Zhang Z, Tsujikawa H, Fusco D, Silverman D, Liang B, Yue L. Du J, et al. Among authors: Zhang Z. Circ Res. 2010 Mar 19;106(5):992-1003. doi: 10.1161/CIRCRESAHA.109.206771. Epub 2010 Jan 14. Circ Res. 2010. PMID: 20075334 Free PMC article.
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