Zhao 2021 J.Med.Chem - Search Results

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2020	4
2021	79
2022	7
2023	0

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79 articles found by citation matching

Discovery of Potent and Selective 2-(Benzylthio)pyrimidine-based DCN1-UBC12 Inhibitors for Anticardiac Fibrotic Effects.

He ZX, et al. J Med Chem. 2022. PMID: 34939411

Novel Cyclic Endomorphin Analogues with Multiple Modifications and Oligoarginine Vector Exhibit Potent Antinociception with Reduced Opioid-like Side Effects.

Zhang YZ, et al. J Med Chem. 2021. PMID: 34781680

Structure-Based Design of Potent, Selective, and Orally Bioavailable VPS34 Kinase Inhibitors.

Hu DX, et al. J Med Chem. 2022. PMID: 34779204

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Discovery of ARD-2585 as an Exceptionally Potent and Orally Active PROTAC Degrader of Androgen Receptor for the Treatment of Advanced Prostate Cancer.

Xiang W, Zhao L, Han X, Qin C, Miao B, McEachern D, Wang Y, Metwally H, Kirchhoff PD, Wang L, Matvekas A, He M, Wen B, Sun D, Wang S. Xiang W, et al. J Med Chem. 2021 Sep 23;64(18):13487-13509. doi: 10.1021/acs.jmedchem.1c00900. Epub 2021 Sep 2. J Med Chem. 2021. PMID: 34473519 Free PMC article.

Aptamer-Based Antibacterial and Antiviral Therapy against Infectious Diseases.

Chen XF, Zhao X, Yang Z. Chen XF, et al. J Med Chem. 2021 Dec 23;64(24):17601-17626. doi: 10.1021/acs.jmedchem.1c01567. Epub 2021 Dec 2. J Med Chem. 2021. PMID: 34854680 Review.

Structural Insights into Notum Covalent Inhibition.

Zhao Y, Svensson F, Steadman D, Frew S, Monaghan A, Bictash M, Moreira T, Chalk R, Lu W, Fish PV, Jones EY. Zhao Y, et al. J Med Chem. 2021 Aug 12;64(15):11354-11363. doi: 10.1021/acs.jmedchem.1c00701. Epub 2021 Jul 22. J Med Chem. 2021. PMID: 34292747 Free PMC article.

Tricyclic-Carbocyclic RORγt Inverse Agonists-Discovery of BMS-986313.

Yang MG, Beaudoin-Bertrand M, Xiao Z, Marcoux D, Weigelt CA, Yip S, Wu DR, Ruzanov M, Sack JS, Wang J, Yarde M, Li S, Shuster DJ, Xie JH, Sherry T, Obermeier MT, Fura A, Stefanski K, Cornelius G, Khandelwal P, Karmakar A, Basha M, Babu V, Gupta AK, Mathur A, Salter-Cid L, Denton R, Zhao Q, Dhar TGM. Yang MG, et al. J Med Chem. 2021 Mar 11;64(5):2714-2724. doi: 10.1021/acs.jmedchem.0c01992. Epub 2021 Feb 16. J Med Chem. 2021. PMID: 33591748

Current Landscape and Future Perspective of Oxazolidinone Scaffolds Containing Antibacterial Drugs.

Zhao Q, Xin L, Liu Y, Liang C, Li J, Jian Y, Li H, Shi Z, Liu H, Cao W. Zhao Q, et al. J Med Chem. 2021 Aug 12;64(15):10557-10580. doi: 10.1021/acs.jmedchem.1c00480. Epub 2021 Jul 14. J Med Chem. 2021. PMID: 34260235 Review.

Recent Progress and Clinical Development of Inhibitors that Block MDM4/p53 Protein-Protein Interactions.

Zhang S, Lou J, Li Y, Zhou F, Yan Z, Lyu X, Zhao Y. Zhang S, et al. J Med Chem. 2021 Aug 12;64(15):10621-10640. doi: 10.1021/acs.jmedchem.1c00940. Epub 2021 Jul 21. J Med Chem. 2021. PMID: 34286973 Review.

Recent Progress of Small Molecule Menin-MLL Interaction Inhibitors as Therapeutic Agents for Acute Leukemia.

Lei H, Zhang SQ, Fan S, Bai HR, Zhao HY, Mao S, Xin M. Lei H, et al. J Med Chem. 2021 Nov 11;64(21):15519-15533. doi: 10.1021/acs.jmedchem.1c00872. Epub 2021 Nov 2. J Med Chem. 2021. PMID: 34726905 Review.

Remdesivir Metabolite GS-441524 Effectively Inhibits SARS-CoV-2 Infection in Mouse Models.

Li Y, Cao L, Li G, Cong F, Li Y, Sun J, Luo Y, Chen G, Li G, Wang P, Xing F, Ji Y, Zhao J, Zhang Y, Guo D, Zhang X. Li Y, et al. J Med Chem. 2022 Feb 24;65(4):2785-2793. doi: 10.1021/acs.jmedchem.0c01929. Epub 2021 Feb 1. J Med Chem. 2022. PMID: 33523654

Discovery of Potent and Selective 2-(Benzylthio)pyrimidine-based DCN1-UBC12 Inhibitors for Anticardiac Fibrotic Effects.

He ZX, An Q, Wei B, Zhou WJ, Wei BF, Gong YP, Zhang X, Gao G, Dong GJ, Huo JL, Zhang XH, Yang FF, Liu HM, Ma LY, Zhao W. He ZX, et al. J Med Chem. 2022 Jan 13;65(1):163-190. doi: 10.1021/acs.jmedchem.1c01207. Epub 2021 Dec 23. J Med Chem. 2022. PMID: 34939411

Structure-Based Design of Potent, Selective, and Orally Bioavailable VPS34 Kinase Inhibitors.

Hu DX, Patel S, Chen H, Wang S, Staben ST, Dimitrova YN, Wallweber HA, Lee JY, Chan GKY, Sneeringer CJ, Prangley MS, Moffat JG, Wu KC, Schutt LK, Salphati L, Pang J, McNamara E, Huang H, Chen Y, Wang Y, Zhao W, Lim J, Murthy A, Siu M. Hu DX, et al. J Med Chem. 2022 Sep 8;65(17):11500-11512. doi: 10.1021/acs.jmedchem.1c01180. Epub 2021 Nov 15. J Med Chem. 2022. PMID: 34779204

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