Zhao R - Search Results

1

Identification of a Small-Molecule Inhibitor That Disrupts the SIX1/EYA2 Complex, EMT, and Metastasis.

Zhou H, Blevins MA, Hsu JY, Kong D, Galbraith MD, Goodspeed A, Culp-Hill R, Oliphant MUJ, Ramirez D, Zhang L, Trinidad-Pineiro J, Mathews Griner L, King R, Barnaeva E, Hu X, Southall NT, Ferrer M, Gustafson DL, Regan DP, D'Alessandro A, Costello JC, Patnaik S, Marugan J, Zhao R, Ford HL. Zhou H, et al. Among authors: zhao r. Cancer Res. 2020 Jun 15;80(12):2689-2702. doi: 10.1158/0008-5472.CAN-20-0435. Epub 2020 Apr 27. Cancer Res. 2020. PMID: 32341035 Free PMC article.

2

Crystal structure of the C-terminal domain of splicing factor Prp8 carrying retinitis pigmentosa mutants.

Zhang L, Shen J, Guarnieri MT, Heroux A, Yang K, Zhao R. Zhang L, et al. Among authors: zhao r. Protein Sci. 2007 Jun;16(6):1024-31. doi: 10.1110/ps.072872007. Epub 2007 May 1. Protein Sci. 2007. PMID: 17473007 Free PMC article.

3

Biochemical characterization of the ATPase and helicase activity of UAP56, an essential pre-mRNA splicing and mRNA export factor.

Shen J, Zhang L, Zhao R. Shen J, et al. Among authors: zhao r. J Biol Chem. 2007 Aug 3;282(31):22544-50. doi: 10.1074/jbc.M702304200. Epub 2007 Jun 11. J Biol Chem. 2007. PMID: 17562711 Free article.

4

The Hsp90 inhibitor radicicol interacts with the ATP-binding pocket of bacterial sensor kinase PhoQ.

Guarnieri MT, Zhang L, Shen J, Zhao R. Guarnieri MT, et al. Among authors: zhao r. J Mol Biol. 2008 May 23;379(1):82-93. doi: 10.1016/j.jmb.2008.03.036. Epub 2008 Mar 26. J Mol Biol. 2008. PMID: 18440021

5

Crystal structure of the beta-finger domain of Prp8 reveals analogy to ribosomal proteins.

Yang K, Zhang L, Xu T, Heroux A, Zhao R. Yang K, et al. Among authors: zhao r. Proc Natl Acad Sci U S A. 2008 Sep 16;105(37):13817-22. doi: 10.1073/pnas.0805960105. Epub 2008 Sep 8. Proc Natl Acad Sci U S A. 2008. PMID: 18779563 Free PMC article.

6

Biochemical and functional characterization of six SIX1 Branchio-oto-renal syndrome mutations.

Patrick AN, Schiemann BJ, Yang K, Zhao R, Ford HL. Patrick AN, et al. Among authors: zhao r. J Biol Chem. 2009 Jul 31;284(31):20781-90. doi: 10.1074/jbc.M109.016832. Epub 2009 Jun 4. J Biol Chem. 2009. PMID: 19497856 Free PMC article.

7

Eya2 is required to mediate the pro-metastatic functions of Six1 via the induction of TGF-β signaling, epithelial-mesenchymal transition, and cancer stem cell properties.

Farabaugh SM, Micalizzi DS, Jedlicka P, Zhao R, Ford HL. Farabaugh SM, et al. Among authors: zhao r. Oncogene. 2012 Feb 2;31(5):552-62. doi: 10.1038/onc.2011.259. Epub 2011 Jun 27. Oncogene. 2012. PMID: 21706047 Free PMC article.

8

Identification of a selective small-molecule inhibitor series targeting the eyes absent 2 (Eya2) phosphatase activity.

Krueger AB, Dehdashti SJ, Southall N, Marugan JJ, Ferrer M, Li X, Ford HL, Zheng W, Zhao R. Krueger AB, et al. Among authors: zhao r. J Biomol Screen. 2013 Jan;18(1):85-96. doi: 10.1177/1087057112453936. Epub 2012 Jul 20. J Biomol Screen. 2013. PMID: 22820394 Free PMC article.

9

Comprehensive in vivo RNA-binding site analyses reveal a role of Prp8 in spliceosomal assembly.

Li X, Zhang W, Xu T, Ramsey J, Zhang L, Hill R, Hansen KC, Hesselberth JR, Zhao R. Li X, et al. Among authors: zhao r. Nucleic Acids Res. 2013 Apr 1;41(6):3805-18. doi: 10.1093/nar/gkt062. Epub 2013 Feb 7. Nucleic Acids Res. 2013. PMID: 23393194 Free PMC article.

10

Structure-function analyses of the human SIX1-EYA2 complex reveal insights into metastasis and BOR syndrome.

Patrick AN, Cabrera JH, Smith AL, Chen XS, Ford HL, Zhao R. Patrick AN, et al. Among authors: zhao r. Nat Struct Mol Biol. 2013 Apr;20(4):447-53. doi: 10.1038/nsmb.2505. Epub 2013 Feb 24. Nat Struct Mol Biol. 2013. PMID: 23435380 Free PMC article.

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