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Impaired de novo choline synthesis explains why phosphatidylethanolamine N-methyltransferase-deficient mice are protected from diet-induced obesity.
Jacobs RL, Zhao Y, Koonen DP, Sletten T, Su B, Lingrell S, Cao G, Peake DA, Kuo MS, Proctor SD, Kennedy BP, Dyck JR, Vance DE. Jacobs RL, et al. Among authors: zhao y. J Biol Chem. 2010 Jul 16;285(29):22403-13. doi: 10.1074/jbc.M110.108514. Epub 2010 May 7. J Biol Chem. 2010. PMID: 20452975 Free PMC article.
Missense mutations in APOB within the betaalpha1 domain of human APOB-100 result in impaired secretion of ApoB and ApoB-containing lipoproteins in familial hypobetalipoproteinemia.
Burnett JR, Zhong S, Jiang ZG, Hooper AJ, Fisher EA, McLeod RS, Zhao Y, Barrett PH, Hegele RA, van Bockxmeer FM, Zhang H, Vance DE, McKnight CJ, Yao Z. Burnett JR, et al. Among authors: zhao y. J Biol Chem. 2007 Aug 17;282(33):24270-83. doi: 10.1074/jbc.M702442200. Epub 2007 Jun 22. J Biol Chem. 2007. PMID: 17588943
Plasma homocysteine is regulated by phospholipid methylation.
Noga AA, Stead LM, Zhao Y, Brosnan ME, Brosnan JT, Vance DE. Noga AA, et al. Among authors: zhao y. J Biol Chem. 2003 Feb 21;278(8):5952-5. doi: 10.1074/jbc.M212194200. Epub 2002 Dec 12. J Biol Chem. 2003. PMID: 12482759
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