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2020 2
2021 18
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21 results

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Page 1
Small-molecule inhibitors of carboxylesterase Notum.
Zhao Y, Jolly S, Benvegnu S, Jones EY, Fish PV. Zhao Y, et al. Future Med Chem. 2021 Jun;13(11):1001-1015. doi: 10.4155/fmc-2021-0036. Epub 2021 Apr 22. Future Med Chem. 2021. PMID: 33882714 Free PMC article. Review.
Indole-thiazole hybrids with anticancer potential.
Chen L, Zhao D, Zhu K, Wang D, Li Y, Qu M, Zhuang Y. Chen L, et al. Future Med Chem. 2026 Mar;18(6):713-728. doi: 10.1080/17568919.2026.2620365. Epub 2026 Jan 30. Future Med Chem. 2026. PMID: 41612898 Review.
This review systematically summarizes the latest advances in the anticancer potential of indole-thiazole hybrids developed since 2021. To delineate the key molecular features that govern the anticancer potency of indole-thiazole hybrids, this review further presents a deta …
This review systematically summarizes the latest advances in the anticancer potential of indole-thiazole hybrids developed since 2021 …
Aptamer-Based Antibacterial and Antiviral Therapy against Infectious Diseases.
Chen XF, Zhao X, Yang Z. Chen XF, et al. J Med Chem. 2021 Dec 23;64(24):17601-17626. doi: 10.1021/acs.jmedchem.1c01567. Epub 2021 Dec 2. J Med Chem. 2021. PMID: 34854680 Review.
Critical technical barriers of therapeutic aptamers are briefly discussed, followed by some future perspectives for their implementation into clinical utility....
Critical technical barriers of therapeutic aptamers are briefly discussed, followed by some future perspectives for their implementat …
Research Development, Optimization and Modifications of Anti-cancer Peptides.
Sun ZG, Zhao LH, Yeh SM, Li ZN, Ming X. Sun ZG, et al. Mini Rev Med Chem. 2021;21(1):58-68. doi: 10.2174/1389557520666200729163146. Mini Rev Med Chem. 2021. PMID: 32767954 Review.
In conclusion, it can be said that anti-cancer peptides will play a major role in the future oncologic clinic....
In conclusion, it can be said that anti-cancer peptides will play a major role in the future oncologic clinic....
Recent Advances in c-Jun N-Terminal Kinase (JNK) Inhibitors.
Li G, Qi W, Li X, Zhao J, Luo M, Chen J. Li G, et al. Curr Med Chem. 2021;28(3):607-627. doi: 10.2174/0929867327666200210144114. Curr Med Chem. 2021. PMID: 32039671 Review.
In this review, we describe the recent development of JNK inhibitors, including ATP competitive and ATP non-competitive (allosteric) inhibitors, bidentatebinding inhibitors and dual inhibitors, the challenges, and the future direction of JNK inhibitors as potential therape …
In this review, we describe the recent development of JNK inhibitors, including ATP competitive and ATP non-competitive (allosteric) inhibit …
Advances in Drug Therapy for Systemic Lupus Erythematosus.
Zhao X, Zhang J, Liang Y, Li J, Ding S, Wang Y, Chen Y, Liu J. Zhao X, et al. Curr Med Chem. 2021;28(6):1251-1268. doi: 10.2174/0929867327666200625150408. Curr Med Chem. 2021. PMID: 32586244 Review.
CONCLUSION: This article describes the pathogenesis of systemic lupus erythematosus, and summarizes the traditional and new therapeutic drugs, which is not only beneficial to the treatment of lupus erythematosus patients, but also plays a vital reference significance for the f …
CONCLUSION: This article describes the pathogenesis of systemic lupus erythematosus, and summarizes the traditional and new therapeutic drug …
Pharmacological inhibition of NF-κB-inducing kinase (NIK) with small molecules for the treatment of human diseases.
Cheng J, Feng X, Li Z, Zhou F, Yang JM, Zhao Y. Cheng J, et al. RSC Med Chem. 2021 Jan 22;12(4):552-565. doi: 10.1039/d0md00361a. eCollection 2021 Apr 28. RSC Med Chem. 2021. PMID: 34046627 Free PMC article. Review.
Information showcased in this review article might be helpful for the discovery and clinical development of the next generation of NIK inhibitors in the near future....
Information showcased in this review article might be helpful for the discovery and clinical development of the next generation of NIK inhib …
21 results