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shRNA targeting α-synuclein prevents neurodegeneration in a Parkinson's disease model.
J Clin Invest. 2015 Jul 1;125(7):2721-35. doi: 10.1172/JCI64502. Epub 2015 Jun 15.
J Clin Invest. 2015.
PMID: 26075822
Free PMC article.
α-Synuclein binds to TOM20 and inhibits mitochondrial protein import in Parkinson's disease.
Di Maio R, Barrett PJ, Hoffman EK, Barrett CW, Zharikov A, Borah A, Hu X, McCoy J, Chu CT, Burton EA, Hastings TG, Greenamyre JT.
Di Maio R, et al.
Sci Transl Med. 2016 Jun 8;8(342):342ra78. doi: 10.1126/scitranslmed.aaf3634.
Sci Transl Med. 2016.
PMID: 27280685
Free PMC article.
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LRRK2 activation in idiopathic Parkinson's disease.
Di Maio R, Hoffman EK, Rocha EM, Keeney MT, Sanders LH, De Miranda BR, Zharikov A, Van Laar A, Stepan AF, Lanz TA, Kofler JK, Burton EA, Alessi DR, Hastings TG, Greenamyre JT.
Di Maio R, et al.
Sci Transl Med. 2018 Jul 25;10(451):eaar5429. doi: 10.1126/scitranslmed.aar5429.
Sci Transl Med. 2018.
PMID: 30045977
Free PMC article.
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Long-term RNAi knockdown of α-synuclein in the adult rat substantia nigra without neurodegeneration.
Zharikov A, Bai Q, De Miranda BR, Van Laar A, Greenamyre JT, Burton EA.
Zharikov A, et al.
Neurobiol Dis. 2019 May;125:146-153. doi: 10.1016/j.nbd.2019.01.004. Epub 2019 Jan 15.
Neurobiol Dis. 2019.
PMID: 30658149
Free PMC article.
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α-Synuclein amplifies cytoplasmic peroxide flux and oxidative stress provoked by mitochondrial inhibitors in CNS dopaminergic neurons in vivo.
Van Laar VS, Chen J, Zharikov AD, Bai Q, Di Maio R, Dukes AA, Hastings TG, Watkins SC, Greenamyre JT, St Croix CM, Burton EA.
Van Laar VS, et al. Among authors: zharikov ad.
Redox Biol. 2020 Oct;37:101695. doi: 10.1016/j.redox.2020.101695. Epub 2020 Aug 22.
Redox Biol. 2020.
PMID: 32905883
Free PMC article.
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NADPH oxidase 2 activity in Parkinson's disease.
Keeney MT, Hoffman EK, Farmer K, Bodle CR, Fazzari M, Zharikov A, Castro SL, Hu X, Mortimer A, Kofler JK, Cifuentes-Pagano E, Pagano PJ, Burton EA, Hastings TG, Greenamyre JT, Di Maio R.
Keeney MT, et al.
Neurobiol Dis. 2022 Aug;170:105754. doi: 10.1016/j.nbd.2022.105754. Epub 2022 May 13.
Neurobiol Dis. 2022.
PMID: 35577065
Free PMC article.
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Transient exposure to rotenone causes degeneration and progressive parkinsonian motor deficits, neuroinflammation, and synucleinopathy.
Van Laar AD, Webb KR, Keeney MT, Van Laar VS, Zharikov A, Burton EA, Hastings TG, Glajch KE, Hirst WD, Greenamyre JT, Rocha EM.
Van Laar AD, et al. Among authors: zharikov a.
NPJ Parkinsons Dis. 2023 Aug 11;9(1):121. doi: 10.1038/s41531-023-00561-6.
NPJ Parkinsons Dis. 2023.
PMID: 37567894
Free PMC article.
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