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Metabolomic profiling and stable isotope labelling of Trichomonas vaginalis and Tritrichomonas foetus reveal major differences in amino acid metabolism including the production of 2-hydroxyisocaproic acid, cystathionine and S-methylcysteine.
Westrop GD, Wang L, Blackburn GJ, Zhang T, Zheng L, Watson DG, Coombs GH. Westrop GD, et al. Among authors: zheng l. PLoS One. 2017 Dec 21;12(12):e0189072. doi: 10.1371/journal.pone.0189072. eCollection 2017. PLoS One. 2017. PMID: 29267346 Free PMC article.
Serine is a natural ligand and allosteric activator of pyruvate kinase M2.
Chaneton B, Hillmann P, Zheng L, Martin ACL, Maddocks ODK, Chokkathukalam A, Coyle JE, Jankevics A, Holding FP, Vousden KH, Frezza C, O'Reilly M, Gottlieb E. Chaneton B, et al. Among authors: zheng l. Nature. 2012 Nov 15;491(7424):458-462. doi: 10.1038/nature11540. Epub 2012 Oct 14. Nature. 2012. PMID: 23064226 Free PMC article.
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