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Aprotinin and similar protease inhibitors as drugs against influenza.
Zhirnov OP, Klenk HD, Wright PF. Zhirnov OP, et al. Antiviral Res. 2011 Oct;92(1):27-36. doi: 10.1016/j.antiviral.2011.07.014. Epub 2011 Jul 23. Antiviral Res. 2011. PMID: 21802447 Review.
Aprotinin, a protease inhibitor, suppresses proteolytic activation of pandemic H1N1v influenza virus.
Zhirnov OP, Matrosovich TY, Matrosovich MN, Klenk HD. Zhirnov OP, et al. Antivir Chem Chemother. 2011 Mar 7;21(4):169-74. doi: 10.3851/IMP1715. Antivir Chem Chemother. 2011. PMID: 21602614
Alterations in caspase cleavage motifs of NP and M2 proteins attenuate virulence of a highly pathogenic avian influenza virus.
Zhirnov OP, Klenk HD. Zhirnov OP, et al. Virology. 2009 Nov 10;394(1):57-63. doi: 10.1016/j.virol.2009.08.013. Epub 2009 Sep 10. Virology. 2009. PMID: 19747708
Influenza virus pathogenicity is determined by caspase cleavage motifs located in the viral proteins.
Zhirnov OP, Syrtzev VV. Zhirnov OP, et al. J Mol Genet Med. 2009 Jan 3;3(1):124-32. doi: 10.4172/1747-0862.1000024. J Mol Genet Med. 2009. PMID: 19565021 Free PMC article.
Protection against mouse and avian influenza A strains via vaccination with a combination of conserved proteins NP, M1 and NS1.
Zhirnov OP, Isaeva EI, Konakova TE, Thoidis G, Piskareva LM, Akopova II, Kartashov A, Altstein AD, Ilyinskii PO, Shneider AM. Zhirnov OP, et al. Influenza Other Respir Viruses. 2007 Mar;1(2):71-9. doi: 10.1111/j.1750-2659.2007.00010.x. Influenza Other Respir Viruses. 2007. PMID: 18784792 Free PMC article.
Cleavage of influenza a virus hemagglutinin in human respiratory epithelium is cell associated and sensitive to exogenous antiproteases.
Zhirnov OP, Ikizler MR, Wright PF. Zhirnov OP, et al. J Virol. 2002 Sep;76(17):8682-9. doi: 10.1128/jvi.76.17.8682-8689.2002. J Virol. 2002. PMID: 12163588 Free PMC article.
Control of apoptosis in influenza virus-infected cells by up-regulation of Akt and p53 signaling.
Zhirnov OP, Klenk HD. Zhirnov OP, et al. Apoptosis. 2007 Aug;12(8):1419-32. doi: 10.1007/s10495-007-0071-y. Apoptosis. 2007. PMID: 17468837
Human influenza A viruses are proteolytically activated and do not induce apoptosis in CACO-2 cells.
Zhirnov O, Klenk HD. Zhirnov O, et al. Virology. 2003 Aug 15;313(1):198-212. doi: 10.1016/s0042-6822(03)00264-2. Virology. 2003. PMID: 12951033
Influenza A virus proteins NS1 and hemagglutinin along with M2 are involved in stimulation of autophagy in infected cells.
Zhirnov OP, Klenk HD. Zhirnov OP, et al. J Virol. 2013 Dec;87(24):13107-14. doi: 10.1128/JVI.02148-13. Epub 2013 Sep 11. J Virol. 2013. PMID: 24027311 Free PMC article.
Zhirnov, T. E. Konakova, T. Wolff, and H. D. Klenk, J. Virol. 76:1617-1625, 2002). In the present study, we analyzed the development of autophagy, another mechanism to protect cells from degradation that depends on NS1 expression. ...
Zhirnov, T. E. Konakova, T. Wolff, and H. D. Klenk, J. Virol. 76:1617-1625, 2002). In the present study, we analyzed the development
[Adsorption on synthetic membranes and immunogenic properties of aprotinin cross-linked by glutaraldehyde].
Timofeeva TA, Goliando PB, Zhirnov OP. Timofeeva TA, et al. Among authors: zhirnov op. Bioorg Khim. 1999 Apr;25(4):264-9. Bioorg Khim. 1999. PMID: 10422592 Russian.
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