Catalpol protects synaptic proteins from beta-amyloid induced neuron injury and improves cognitive functions in aged rats.
Oncotarget. 2017 May 17;8(41):69303-69315. doi: 10.18632/oncotarget.17951. eCollection 2017 Sep 19.
Free PMC article.
Synapse loss is one of the common factors contributing to cognitive disorders, such as Alzheimer's disease (AD), which is manifested by the impairment of basic cognitive functions including memory processing, perception, problem solving, and language. ...In beta-amyloid (Aβ) injured primary rat's cortical neuron, catalpol did not increase the viability of neuron but extended the length of microtubule-associated protein 2 (MAP-2) positive neurites and reversed the suppressive effects on expression of synaptic proteins induced by Aβ. ...
Synapse loss is one of the common factors contributing to cognitive disorders, such as Alzheimer's disease (AD), which is manifested …