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The mTOR pathway is frequently activated in pancreatic ductal adenocarcinoma and chronic pancreatitis.
Bellizzi AM, Bloomston M, Zhou XP, Iwenofu OH, Frankel WL. Bellizzi AM, et al. Among authors: zhou xp. Appl Immunohistochem Mol Morphol. 2010 Oct;18(5):442-7. doi: 10.1097/PAI.0b013e3181de115b. Appl Immunohistochem Mol Morphol. 2010. PMID: 20661135
Phosphatase and tensin homolog immunohistochemical staining and clinical criteria for Cowden syndrome in patients with trichilemmoma or associated lesions.
Jin M, Hampel H, Pilarski R, Zhou X, Peters S, Frankel WL. Jin M, et al. Among authors: zhou x. Am J Dermatopathol. 2013 Aug;35(6):637-40. doi: 10.1097/DAD.0b013e31827e28f7. Am J Dermatopathol. 2013. PMID: 23715080
Liver Metastases of Neuroendocrine Tumors Rarely Show Overlapping Immunoprofile with Hepatocellular Carcinomas.
Jin M, Zhou X, Yearsley M, Frankel WL. Jin M, et al. Among authors: zhou x. Endocr Pathol. 2016 Sep;27(3):253-8. doi: 10.1007/s12022-016-9442-7. Endocr Pathol. 2016. PMID: 27300354 Free PMC article.
High frequency of submicroscopic hemizygous deletion is a major mechanism of loss of expression of PTEN in uveal melanoma.
Abdel-Rahman MH, Yang Y, Zhou XP, Craig EL, Davidorf FH, Eng C. Abdel-Rahman MH, et al. Among authors: zhou xp. J Clin Oncol. 2006 Jan 10;24(2):288-95. doi: 10.1200/JCO.2005.02.2418. Epub 2005 Dec 12. J Clin Oncol. 2006. PMID: 16344319
Molecular classification of patients with unexplained hamartomatous and hyperplastic polyposis.
Sweet K, Willis J, Zhou XP, Gallione C, Sawada T, Alhopuro P, Khoo SK, Patocs A, Martin C, Bridgeman S, Heinz J, Pilarski R, Lehtonen R, Prior TW, Frebourg T, Teh BT, Marchuk DA, Aaltonen LA, Eng C. Sweet K, et al. Among authors: zhou xp. JAMA. 2005 Nov 16;294(19):2465-73. doi: 10.1001/jama.294.19.2465. JAMA. 2005. PMID: 16287957
Germline inactivation of PTEN and dysregulation of the phosphoinositol-3-kinase/Akt pathway cause human Lhermitte-Duclos disease in adults.
Zhou XP, Marsh DJ, Morrison CD, Chaudhury AR, Maxwell M, Reifenberger G, Eng C. Zhou XP, et al. Am J Hum Genet. 2003 Nov;73(5):1191-8. doi: 10.1086/379382. Epub 2003 Oct 17. Am J Hum Genet. 2003. PMID: 14566704 Free PMC article.
Germline PTEN promoter mutations and deletions in Cowden/Bannayan-Riley-Ruvalcaba syndrome result in aberrant PTEN protein and dysregulation of the phosphoinositol-3-kinase/Akt pathway.
Zhou XP, Waite KA, Pilarski R, Hampel H, Fernandez MJ, Bos C, Dasouki M, Feldman GL, Greenberg LA, Ivanovich J, Matloff E, Patterson A, Pierpont ME, Russo D, Nassif NT, Eng C. Zhou XP, et al. Am J Hum Genet. 2003 Aug;73(2):404-11. doi: 10.1086/377109. Epub 2003 Jul 3. Am J Hum Genet. 2003. PMID: 12844284 Free PMC article.
Frequent somatic mutations in PTEN and TP53 are mutually exclusive in the stroma of breast carcinomas.
Kurose K, Gilley K, Matsumoto S, Watson PH, Zhou XP, Eng C. Kurose K, et al. Among authors: zhou xp. Nat Genet. 2002 Nov;32(3):355-7. doi: 10.1038/ng1013. Epub 2002 Oct 15. Nat Genet. 2002. PMID: 12379854
PTEN mutational spectra, expression levels, and subcellular localization in microsatellite stable and unstable colorectal cancers.
Zhou XP, Loukola A, Salovaara R, Nystrom-Lahti M, Peltomäki P, de la Chapelle A, Aaltonen LA, Eng C. Zhou XP, et al. Am J Pathol. 2002 Aug;161(2):439-47. doi: 10.1016/S0002-9440(10)64200-9. Am J Pathol. 2002. PMID: 12163369 Free PMC article.
Distinct PTEN mutational spectra in hereditary non-polyposis colon cancer syndrome-related endometrial carcinomas compared to sporadic microsatellite unstable tumors.
Zhou XP, Kuismanen S, Nystrom-Lahti M, Peltomaki P, Eng C. Zhou XP, et al. Hum Mol Genet. 2002 Feb 15;11(4):445-50. doi: 10.1093/hmg/11.4.445. Hum Mol Genet. 2002. PMID: 11854177
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