Brominated aliphatic hydrocarbons and sterols from the sponge Xestospongia testudinaria with their bioactivities

Chem Phys Lipids. 2011 Oct;164(7):703-6. doi: 10.1016/j.chemphyslip.2011.08.002. Epub 2011 Aug 16.

Abstract

Four brominated aliphatic hydrocarbons (1-4), including a novel brominated ene-tetrahydrofuran named as mutafuran H (1), and five sterols (5-9) were isolated from the South China Sea sponge Xestospongia testudinaria. The structure of 1 was determined on the basis of NMR ((1)H, (13)C NMR, HSQC, HMBC, (1)H-(1)H COSY, and NOESY), MS, and optical rotation analysis. Known compounds were identified by comparison of their NMR data with those reported in the literature. Compounds 1-4, and 6-9 were evaluated for their toxicity against Artemia salina larvae, and anti-acetylcholinesterase activity.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acetylcholinesterase / chemistry
  • Acetylcholinesterase / metabolism
  • Animals
  • Artemia / drug effects
  • Artemia / embryology
  • Cholinesterase Inhibitors / chemistry
  • Cholinesterase Inhibitors / isolation & purification
  • Cholinesterase Inhibitors / toxicity
  • Hydrocarbons, Brominated / chemistry*
  • Hydrocarbons, Brominated / isolation & purification
  • Hydrocarbons, Brominated / toxicity
  • Larva / drug effects
  • Magnetic Resonance Spectroscopy
  • Molecular Conformation
  • Sterols / chemistry*
  • Sterols / isolation & purification
  • Sterols / toxicity
  • Xestospongia / chemistry*

Substances

  • Cholinesterase Inhibitors
  • Hydrocarbons, Brominated
  • Sterols
  • Acetylcholinesterase