Abstract
Four brominated aliphatic hydrocarbons (1-4), including a novel brominated ene-tetrahydrofuran named as mutafuran H (1), and five sterols (5-9) were isolated from the South China Sea sponge Xestospongia testudinaria. The structure of 1 was determined on the basis of NMR ((1)H, (13)C NMR, HSQC, HMBC, (1)H-(1)H COSY, and NOESY), MS, and optical rotation analysis. Known compounds were identified by comparison of their NMR data with those reported in the literature. Compounds 1-4, and 6-9 were evaluated for their toxicity against Artemia salina larvae, and anti-acetylcholinesterase activity.
Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acetylcholinesterase / chemistry
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Acetylcholinesterase / metabolism
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Animals
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Artemia / drug effects
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Artemia / embryology
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Cholinesterase Inhibitors / chemistry
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Cholinesterase Inhibitors / isolation & purification
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Cholinesterase Inhibitors / toxicity
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Hydrocarbons, Brominated / chemistry*
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Hydrocarbons, Brominated / isolation & purification
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Hydrocarbons, Brominated / toxicity
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Larva / drug effects
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Magnetic Resonance Spectroscopy
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Molecular Conformation
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Sterols / chemistry*
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Sterols / isolation & purification
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Sterols / toxicity
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Xestospongia / chemistry*
Substances
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Cholinesterase Inhibitors
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Hydrocarbons, Brominated
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Sterols
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Acetylcholinesterase