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Alaska Native smokers and smokeless tobacco users with slower CYP2A6 activity have lower tobacco consumption, lower tobacco-specific nitrosamine exposure and lower tobacco-specific nitrosamine bioactivation.
Zhu AZ, Binnington MJ, Renner CC, Lanier AP, Hatsukami DK, Stepanov I, Watson CH, Sosnoff CS, Benowitz NL, Tyndale RF. Zhu AZ, et al. Carcinogenesis. 2013 Jan;34(1):93-101. doi: 10.1093/carcin/bgs306. Epub 2012 Oct 1. Carcinogenesis. 2013. PMID: 23027621 Free PMC article.
Variation in P450 oxidoreductase (POR) A503V and flavin-containing monooxygenase (FMO)-3 E158K is associated with minor alterations in nicotine metabolism, but does not alter cigarette consumption.
Chenoweth MJ, Zhu AZ, Sanderson Cox L, Ahluwalia JS, Benowitz NL, Tyndale RF. Chenoweth MJ, et al. Among authors: zhu az. Pharmacogenet Genomics. 2014 Mar;24(3):172-6. doi: 10.1097/FPC.0000000000000031. Pharmacogenet Genomics. 2014. PMID: 24448396 Free PMC article.
43 results