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Zika Virus Pathogenesis and Tissue Tropism.
Miner JJ, Diamond MS. Miner JJ, et al. Cell Host Microbe. 2017 Feb 8;21(2):134-142. doi: 10.1016/j.chom.2017.01.004. Cell Host Microbe. 2017. PMID: 28182948 Free PMC article. Review.
In this Review, we highlight recent advances in our understanding of ZIKV pathogenesis, tissue tropism, and the resulting pathology and discuss areas for future investigation....
In this Review, we highlight recent advances in our understanding of ZIKV pathogenesis, tissue tropism, and the resulting pathology a …
Biology of Zika Virus Infection in Human Skin Cells.
Hamel R, Dejarnac O, Wichit S, Ekchariyawat P, Neyret A, Luplertlop N, Perera-Lecoin M, Surasombatpattana P, Talignani L, Thomas F, Cao-Lormeau VM, Choumet V, Briant L, Desprès P, Amara A, Yssel H, Missé D. Hamel R, et al. J Virol. 2015 Sep;89(17):8880-96. doi: 10.1128/JVI.00354-15. Epub 2015 Jun 17. J Virol. 2015. PMID: 26085147 Free PMC article.
The results presented herein permit us to gain further insight into the biology of ZIKV and to devise strategies aiming to interfere with the pathology caused by this emerging flavivirus. IMPORTANCE: Zika virus (ZIKV) is an arbovirus belonging to the Flaviviridae family. . …
The results presented herein permit us to gain further insight into the biology of ZIKV and to devise strategies aiming to interfere with th …
Zika Virus: Pathology From the Pandemic.
Ritter JM, Martines RB, Zaki SR. Ritter JM, et al. Arch Pathol Lab Med. 2017 Jan;141(1):49-59. doi: 10.5858/arpa.2016-0397-SA. Epub 2016 Oct 5. Arch Pathol Lab Med. 2017. PMID: 27704909 Free article. Review.
OBJECTIVE: -To summarize the syndromes and pathology associated with ZIKV infection, the implications of pathologic findings in the pathogenesis of ZIKV disease, and the use of pathology specimens for diagnosis of ZIKV infection. ...CONCLUSIONS: -Pathologic findings …
OBJECTIVE: -To summarize the syndromes and pathology associated with ZIKV infection, the implications of pathologic findings in the p …
Zika virus-induced neuro-ocular pathology in immunocompetent mice correlates with anti-ganglioside autoantibodies.
Beaver JT, Mills LK, Swieboda D, Lelutiu N, Esser ES, Antao OQ, Scountzou E, Williams DT, Papaioannou N, Littauer EQ, Skountzou I. Beaver JT, et al. Hum Vaccin Immunother. 2020 Sep 1;16(9):2092-2108. doi: 10.1080/21645515.2020.1775459. Epub 2020 Aug 6. Hum Vaccin Immunother. 2020. PMID: 32758108 Free PMC article.
This pathology persisted 100 days after infection with evidence of chronic inflammation in immune-privileged tissues, demyelination in the hippocampus and motor cortex regions of the brain, and retinal/corneal hyperplasia. Anti-inflammatory transcriptional responses were t …
This pathology persisted 100 days after infection with evidence of chronic inflammation in immune-privileged tissues, demyelination i …
Zika virus infection and implications for kidney disease.
Alcendor DJ. Alcendor DJ. J Mol Med (Berl). 2018 Nov;96(11):1145-1151. doi: 10.1007/s00109-018-1692-z. Epub 2018 Aug 31. J Mol Med (Berl). 2018. PMID: 30171265 Free PMC article. Review.
High-level and persistent viruria observed in patients infected by Zika virus (ZIKV) has been well documented. However, renal pathology in acutely infected, immunocompetent patients remains subclinical. ...The observation that long-term viral shedding occurs in the renal c …
High-level and persistent viruria observed in patients infected by Zika virus (ZIKV) has been well documented. However, renal pathology
[The Recent Epidemic Spread of Zika Virus Disease].
Lim CK. Lim CK. Uirusu. 2018;68(1):1-12. doi: 10.2222/jsv.68.1. Uirusu. 2018. PMID: 31105130 Free article. Review. Japanese.
Currently, research on ZIKV has progressed remarkably thus this article aims to review recent progress in virology, epidemiology, and pathology of ZIKV infection....
Currently, research on ZIKV has progressed remarkably thus this article aims to review recent progress in virology, epidemiology, and pat
Cutaneous vaccination ameliorates Zika virus-induced neuro-ocular pathology via reduction of anti-ganglioside antibodies.
Beaver JT, Mills LK, Swieboda D, Lelutiu N, Esser ES, Antao OQ, Scountzou E, Williams DT, Papaioannou N, Littauer EQ, Romanyuk A, Compans RW, Prausnitz MR, Skountzou I. Beaver JT, et al. Hum Vaccin Immunother. 2020 Sep 1;16(9):2072-2091. doi: 10.1080/21645515.2020.1775460. Epub 2020 Aug 6. Hum Vaccin Immunother. 2020. PMID: 32758106 Free PMC article.
MNP vaccination effectively controlled viremia and inflammation, preventing neuro-ocular pathology. Conversely, IM vaccination exacerbated ocular pathology, resulting in uncontrolled, long-term inflammation. Importantly, neuro-ocular pathology correlated with …
MNP vaccination effectively controlled viremia and inflammation, preventing neuro-ocular pathology. Conversely, IM vaccination exacer …
In Vitro Inhibition of Zika Virus Replication with Poly(Sodium 4-Styrenesulfonate).
Botwina P, Obłoza M, Szczepański A, Szczubiałka K, Nowakowska M, Pyrć K. Botwina P, et al. Viruses. 2020 Aug 23;12(9):926. doi: 10.3390/v12090926. Viruses. 2020. PMID: 32842540 Free PMC article.
The explosive transmission of the virus in the last ten years put it in the limelight and improved our understanding of its biology and pathology. Currently, no vaccine or drugs are available to prevent or treat ZIKV infections. ...
The explosive transmission of the virus in the last ten years put it in the limelight and improved our understanding of its biology and p
Complementary Mechanisms Potentially Involved in the Pathology of Zika Virus.
Ojha CR, Rodriguez M, Lapierre J, Muthu Karuppan MK, Branscome H, Kashanchi F, El-Hage N. Ojha CR, et al. Front Immunol. 2018 Oct 15;9:2340. doi: 10.3389/fimmu.2018.02340. eCollection 2018. Front Immunol. 2018. PMID: 30374352 Free PMC article. Review.
Though some of the putative viral entry receptors have been identified for ZIKV entry into the target cells, the exact mechanism of ZIKV entry or induced pathology are still not clear. Some of the important host cellular pathways including the toll-like receptor (TLR), aut …
Though some of the putative viral entry receptors have been identified for ZIKV entry into the target cells, the exact mechanism of ZIKV ent …
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