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Transfusion of red blood cells after prolonged storage produces harmful effects that are mediated by iron and inflammation.
Hod EA, Zhang N, Sokol SA, Wojczyk BS, Francis RO, Ansaldi D, Francis KP, Della-Latta P, Whittier S, Sheth S, Hendrickson JE, Zimring JC, Brittenham GM, Spitalnik SL. Hod EA, et al. Among authors: zimring jc. Blood. 2010 May 27;115(21):4284-92. doi: 10.1182/blood-2009-10-245001. Epub 2010 Mar 18. Blood. 2010. PMID: 20299509 Free PMC article.
Transfusion of human volunteers with older, stored red blood cells produces extravascular hemolysis and circulating non-transferrin-bound iron.
Hod EA, Brittenham GM, Billote GB, Francis RO, Ginzburg YZ, Hendrickson JE, Jhang J, Schwartz J, Sharma S, Sheth S, Sireci AN, Stephens HL, Stotler BA, Wojczyk BS, Zimring JC, Spitalnik SL. Hod EA, et al. Among authors: zimring jc. Blood. 2011 Dec 15;118(25):6675-82. doi: 10.1182/blood-2011-08-371849. Epub 2011 Oct 20. Blood. 2011. PMID: 22021369 Free PMC article. Clinical Trial.
190 results