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Zinc depletion induces ribosome hibernation in mycobacteria.
Li Y, Sharma MR, Koripella RK, Yang Y, Kaushal PS, Lin Q, Wade JT, Gray TA, Derbyshire KM, Agrawal RK, Ojha AK. Li Y, et al. Proc Natl Acad Sci U S A. 2018 Aug 7;115(32):8191-8196. doi: 10.1073/pnas.1804555115. Epub 2018 Jul 23. Proc Natl Acad Sci U S A. 2018. PMID: 30038002 Free PMC article.
MPY binding is dependent on another mycobacterial protein, MPY recruitment factor (MRF), which is induced on zinc depletion, and interacts with C- ribosomes. MPY binding confers structural stability to C- ribosomes, promoting survival of growth- …
MPY binding is dependent on another mycobacterial protein, MPY recruitment factor (MRF), which is induced on zinc depletion
Progression from remodeling to hibernation of ribosomes in zinc-starved mycobacteria.
Li Y, Corro JH, Palmer CD, Ojha AK. Li Y, et al. Proc Natl Acad Sci U S A. 2020 Aug 11;117(32):19528-19537. doi: 10.1073/pnas.2013409117. Epub 2020 Jul 28. Proc Natl Acad Sci U S A. 2020. PMID: 32723821 Free PMC article.
In this study, we delineate the conditions for ribosome remodeling and hibernation and provide further insight into how zinc depletion induces Mpy recruitment to C- ribosomes. ...Together, we propose that ribosome hibernation
In this study, we delineate the conditions for ribosome remodeling and hibernation and provide further insight into how zin
Replacement of S14 Protein in Ribosomes of Zinc-Starved Mycobacteria Reduces Spectinamide Sensitivity.
Li Y, Koripella RK, Sharma MR, Lee RE, Agrawal RK, Ojha AK. Li Y, et al. Antimicrob Agents Chemother. 2021 Feb 17;65(3):e01833-20. doi: 10.1128/AAC.01833-20. Print 2021 Feb 17. Antimicrob Agents Chemother. 2021. PMID: 33361293 Free PMC article.
Zinc is an essential micronutrient for mycobacteria, and its depletion induces multiple adaptive changes in cellular physiology, the most remarkable of which are remodeling and hibernation of ribosomes. Ribosome remodeling, indu
Zinc is an essential micronutrient for mycobacteria, and its depletion induces multiple adaptive changes in cell