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Did you mean zinco OR 71431-46-4 [rn] (285 results)?
Vibrio cholerae soluble hemagglutinin/protease is a metalloenzyme.
Booth BA, Boesman-Finkelstein M, Finkelstein RA. Booth BA, et al. Infect Immun. 1983 Nov;42(2):639-44. doi: 10.1128/iai.42.2.639-644.1983. Infect Immun. 1983. PMID: 6417020 Free PMC article.
Both its hemagglutinative and protease functions are inhibited by chelating agents, including Zincov, a hydroxamic acid derivative specifically designed to inhibit zinc metalloproteases. Thermolysin, a known zinc-containing protease, also causes hemagglutination of respond …
Both its hemagglutinative and protease functions are inhibited by chelating agents, including Zincov, a hydroxamic acid derivative sp …
Kinin and enkephalin conversion by an endothelial, plasma membrane carboxypeptidase.
Palmieri FE, Bausback HH, Churchill L, Ward PE. Palmieri FE, et al. Biochem Pharmacol. 1986 Aug 15;35(16):2749-56. doi: 10.1016/0006-2952(86)90185-1. Biochem Pharmacol. 1986. PMID: 3091032
Conversion was also inhibited by o-phenanthroline and EDTA, whereas inhibitors of aminopeptidases (bestatin, puromycin), endopeptidases (phosphoramidon), "enkephalinase" (ZINCOV) or enkephalin convertase (PCMS) were without effect. The affinity of the endothelial plasma me …
Conversion was also inhibited by o-phenanthroline and EDTA, whereas inhibitors of aminopeptidases (bestatin, puromycin), endopeptidases (pho …
Substance P and neurokinin A metabolism by cultured human skeletal muscle myocytes and fibroblasts.
Russell JS, Chi H, Lantry LE, Stephens RE, Ward PE. Russell JS, et al. Peptides. 1996;17(8):1397-403. doi: 10.1016/s0196-9781(96)00201-x. Peptides. 1996. PMID: 8971937
NEP-24.11 was inhibited by phosphoramidon (IC50 = 80 nM), thiorphan and ZINCOV, DAP IV by diprotin A (IC50 = 8 microM), and APN by amastatin (IC50 = 50 nM) and bestatin (IC50 = 100 microM). ...
NEP-24.11 was inhibited by phosphoramidon (IC50 = 80 nM), thiorphan and ZINCOV, DAP IV by diprotin A (IC50 = 8 microM), and APN by am …
Monoclonal antibodies against Pseudomonas aeruginosa elastase: a neutralizing antibody which recognizes a conformational epitope related to an active site of elastase.
Yokota S, Ohtsuka H, Noguchi H. Yokota S, et al. Eur J Biochem. 1992 Jun 1;206(2):587-93. doi: 10.1111/j.1432-1033.1992.tb16963.x. Eur J Biochem. 1992. PMID: 1375917 Free article.
The Ki value for furylacryloyl-glycl-leucinamide of E-4D3, as well as its Fab fragment, was comparable to those for metalloprotease inhibitors such as phosphoramidon and Zincov inhibitor. The binding of mAb E-4D3 was inhibited by phosphoramidon and Zincov inhibitor, …
The Ki value for furylacryloyl-glycl-leucinamide of E-4D3, as well as its Fab fragment, was comparable to those for metalloprotease inhibito …
Aspirin ingestion impairs oral mucosal ulcer healing by inducing membrane-bound tumor necrosis factor-alpha release.
Slomiany BL, Slomiany A. Slomiany BL, et al. IUBMB Life. 2000 Dec;50(6):391-5. doi: 10.1080/713803747. IUBMB Life. 2000. PMID: 11327313 Free article.
Moreover, by the 10th day, the delay in ulcer healing by aspirin was manifested in a 5.6-fold higher rate of apoptosis and a 5.2-fold higher level of soluble TNF-alpha, yet the expression of membrane-bound TNF-alpha showed a 38% decline. Treatment with metalloprotease inhibitor, …
Moreover, by the 10th day, the delay in ulcer healing by aspirin was manifested in a 5.6-fold higher rate of apoptosis and a 5.2-fold higher …
Purification and properties of a small latent matrix metalloproteinase of the rat uterus.
Woessner JF Jr, Taplin CJ. Woessner JF Jr, et al. J Biol Chem. 1988 Nov 15;263(32):16918-25. J Biol Chem. 1988. PMID: 3182822 Free article.
The enzyme is not inhibited by low levels of phosphoramidon or Zincov. Its properties clearly distinguish it from collagenase, gelatinase (matrix metalloproteinase 2), and stromelysin (matrix metalloproteinase 3); it therefore constitutes a further member of the family of …
The enzyme is not inhibited by low levels of phosphoramidon or Zincov. Its properties clearly distinguish it from collagenase, gelati …
Vibrio cholerae hemagglutinin/protease (HA/protease) causes morphological changes in cultured epithelial cells and perturbs their paracellular barrier function.
Wu Z, Milton D, Nybom P, Sjö A, Magnusson KE. Wu Z, et al. Microb Pathog. 1996 Aug;21(2):111-23. doi: 10.1006/mpat.1996.0047. Microb Pathog. 1996. PMID: 8844654
A concentrated protein sample from the 37 degrees C overnight culture supernatant of CVD110, a delta ctxA, delta zot, delta Ace and hlyA::(ctxB mer) mutant of El Tor biotype Ogawa serotype strain E7946 caused morphological changes in cultured MDCK-I epithelial cells and altered t …
A concentrated protein sample from the 37 degrees C overnight culture supernatant of CVD110, a delta ctxA, delta zot, delta Ace and hlyA::(c …
Effects of cobalt-substitution of the active zinc ion in thermolysin on its activity and active-site microenvironment.
Kuzuya K, Inouye K. Kuzuya K, et al. J Biochem. 2001 Dec;130(6):783-8. doi: 10.1093/oxfordjournals.jbchem.a003049. J Biochem. 2001. PMID: 11726278 Free article.
These pK(a) values remain constant in the presence of 4 M NaCl, indicating that the electrostatic environment of cobalt-substituted thermolysin is more stable than that of the native enzyme, the acidic pK(a) of which shifts remarkably from 5.6 to 6.7 at 4 M NaCl. Zincov, a …
These pK(a) values remain constant in the presence of 4 M NaCl, indicating that the electrostatic environment of cobalt-substituted thermoly …
Vibrio cholerae metalloproteinase degrades intestinal mucin and facilitates enterotoxin-induced secretion from rat intestine.
Crowther RS, Roomi NW, Fahim RE, Forstner JF. Crowther RS, et al. Biochim Biophys Acta. 1987 Jun 22;924(3):393-402. doi: 10.1016/0304-4165(87)90153-x. Biochim Biophys Acta. 1987. PMID: 3297167
The carbohydrate composition was essentially unaltered. Inhibition of the filtrate metalloproteinase by Zincov and alpha 2-macroglobulin significantly (P less than 0.005) reduced the ability of cholera filtrate to degrade mucin or to stimulate mucin secretion from rat inte …
The carbohydrate composition was essentially unaltered. Inhibition of the filtrate metalloproteinase by Zincov and alpha 2-macroglobu …
Distinct effects of Vibrio cholerae haemagglutinin/protease on the structure and localization of the tight junction-associated proteins occludin and ZO-1.
Wu Z, Nybom P, Magnusson KE. Wu Z, et al. Cell Microbiol. 2000 Feb;2(1):11-7. doi: 10.1046/j.1462-5822.2000.00025.x. Cell Microbiol. 2000. PMID: 11207559
Western blot analysis showed that occludin bands of 66-85 kDa were digested by HA/P to two predominant bands of around 50 kDa and 35 kDa, and that this degradation was greatly attenuated when the specific bacterial metalloproteinase inhibitor Zincov was co-administered. Tr …
Western blot analysis showed that occludin bands of 66-85 kDa were digested by HA/P to two predominant bands of around 50 kDa and 35 kDa, an …
28 results