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51 results
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Crystallographic studies on two bioisosteric analogues, N-acetyl-beta-D-glucopyranosylamine and N-trifluoroacetyl-beta-D-glucopyranosylamine, potent inhibitors of muscle glycogen phosphorylase.
Anagnostou E, Kosmopoulou MN, Chrysina ED, Leonidas DD, Hadjiloi T, Tiraidis C, Zographos SE, Györgydeák Z, Somsák L, Docsa T, Gergely P, Kolisis FN, Oikonomakos NG. Anagnostou E, et al. Among authors: zographos se. Bioorg Med Chem. 2006 Jan 1;14(1):181-9. doi: 10.1016/j.bmc.2005.08.010. Epub 2005 Oct 4. Bioorg Med Chem. 2006. PMID: 16213146
Naturally occurring pentacyclic triterpenes as inhibitors of glycogen phosphorylase: synthesis, structure-activity relationships, and X-ray crystallographic studies.
Wen X, Sun H, Liu J, Cheng K, Zhang P, Zhang L, Hao J, Zhang L, Ni P, Zographos SE, Leonidas DD, Alexacou KM, Gimisis T, Hayes JM, Oikonomakos NG. Wen X, et al. Among authors: zographos se. J Med Chem. 2008 Jun 26;51(12):3540-54. doi: 10.1021/jm8000949. Epub 2008 Jun 3. J Med Chem. 2008. PMID: 18517260
New inhibitors of glycogen phosphorylase as potential antidiabetic agents.
Somsák L, Czifrák K, Tóth M, Bokor E, Chrysina ED, Alexacou KM, Hayes JM, Tiraidis C, Lazoura E, Leonidas DD, Zographos SE, Oikonomakos NG. Somsák L, et al. Among authors: zographos se. Curr Med Chem. 2008;15(28):2933-83. doi: 10.2174/092986708786848659. Curr Med Chem. 2008. PMID: 19075645 Review.
Inhibitor design for ribonuclease A: the binding of two 5'-phosphate uridine analogues.
Tsirkone VG, Dossi K, Drakou C, Zographos SE, Kontou M, Leonidas DD. Tsirkone VG, et al. Among authors: zographos se. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2009 Jul 1;65(Pt 7):671-7. doi: 10.1107/S1744309109021423. Epub 2009 Jun 27. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2009. PMID: 19574636 Free PMC article.
Glucose-based spiro-isoxazolines: a new family of potent glycogen phosphorylase inhibitors.
Benltifa M, Hayes JM, Vidal S, Gueyrard D, Goekjian PG, Praly JP, Kizilis G, Tiraidis C, Alexacou KM, Chrysina ED, Zographos SE, Leonidas DD, Archontis G, Oikonomakos NG. Benltifa M, et al. Among authors: zographos se. Bioorg Med Chem. 2009 Oct 15;17(20):7368-80. doi: 10.1016/j.bmc.2009.08.060. Epub 2009 Sep 2. Bioorg Med Chem. 2009. PMID: 19781947
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