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Rational design of macrolides by virtual screening of combinatorial libraries generated through in silico manipulation of polyketide synthases.
Zotchev SB, Stepanchikova AV, Sergeyko AP, Sobolev BN, Filimonov DA, Poroikov VV. Zotchev SB, et al. J Med Chem. 2006 Mar 23;49(6):2077-87. doi: 10.1021/jm051035i. J Med Chem. 2006. PMID: 16539396
New natural products identified by combined genomics-metabolomics profiling of marine Streptomyces sp. MP131-18.
Paulus C, Rebets Y, Tokovenko B, Nadmid S, Terekhova LP, Myronovskyi M, Zotchev SB, Rückert C, Braig S, Zahler S, Kalinowski J, Luzhetskyy A. Paulus C, et al. Among authors: zotchev sb. Sci Rep. 2017 Feb 10;7:42382. doi: 10.1038/srep42382. Sci Rep. 2017. PMID: 28186197 Free PMC article.
Development of a Biosensor Concept to Detect the Production of Cluster-Specific Secondary Metabolites.
Sun YQ, Busche T, Rückert C, Paulus C, Rebets Y, Novakova R, Kalinowski J, Luzhetskyy A, Kormanec J, Sekurova ON, Zotchev SB. Sun YQ, et al. Among authors: zotchev sb. ACS Synth Biol. 2017 Jun 16;6(6):1026-1033. doi: 10.1021/acssynbio.6b00353. Epub 2017 Mar 3. ACS Synth Biol. 2017. PMID: 28221784
Marine actinomycetes as an emerging resource for the drug development pipelines.
Zotchev SB. Zotchev SB. J Biotechnol. 2012 Apr 30;158(4):168-75. doi: 10.1016/j.jbiotec.2011.06.002. Epub 2011 Jun 12. J Biotechnol. 2012. PMID: 21683100 Review.
Violacein-producing Collimonas sp. from the sea surface microlayer of costal waters in Trøndelag, Norway.
Hakvåg S, Fjaervik E, Klinkenberg G, Borgos SE, Josefsen KD, Ellingsen TE, Zotchev SB. Hakvåg S, et al. Among authors: zotchev sb. Mar Drugs. 2009 Nov 12;7(4):576-88. doi: 10.3390/md7040576. Mar Drugs. 2009. PMID: 20098599 Free PMC article.
Characterization of Streptomyces spp. isolated from the sea surface microlayer in the Trondheim Fjord, Norway.
Hakvåg S, Fjaervik E, Josefsen KD, Ian E, Ellingsen TE, Zotchev SB. Hakvåg S, et al. Among authors: zotchev sb. Mar Drugs. 2008;6(4):620-35. doi: 10.3390/md6040620. Epub 2008 Dec 1. Mar Drugs. 2008. PMID: 19172199 Free PMC article.
Initiation of polyene macrolide biosynthesis: interplay between polyketide synthase domains and modules as revealed via domain swapping, mutagenesis, and heterologous complementation.
Heia S, Borgos SE, Sletta H, Escudero L, Seco EM, Malpartida F, Ellingsen TE, Zotchev SB. Heia S, et al. Among authors: zotchev sb. Appl Environ Microbiol. 2011 Oct;77(19):6982-90. doi: 10.1128/AEM.05781-11. Epub 2011 Aug 5. Appl Environ Microbiol. 2011. PMID: 21821762 Free PMC article.
New nystatin-related antifungal polyene macrolides with altered polyol region generated via biosynthetic engineering of Streptomyces noursei.
Brautaset T, Sletta H, Degnes KF, Sekurova ON, Bakke I, Volokhan O, Andreassen T, Ellingsen TE, Zotchev SB. Brautaset T, et al. Among authors: zotchev sb. Appl Environ Microbiol. 2011 Sep;77(18):6636-43. doi: 10.1128/AEM.05780-11. Epub 2011 Jul 15. Appl Environ Microbiol. 2011. PMID: 21764946 Free PMC article.
Biosynthesis of macrolactam BE-14106 involves two distinct PKS systems and amino acid processing enzymes for generation of the aminoacyl starter unit.
Jørgensen H, Degnes KF, Sletta H, Fjaervik E, Dikiy A, Herfindal L, Bruheim P, Klinkenberg G, Bredholt H, Nygård G, Døskeland SO, Ellingsen TE, Zotchev SB. Jørgensen H, et al. Among authors: zotchev sb. Chem Biol. 2009 Oct 30;16(10):1109-21. doi: 10.1016/j.chembiol.2009.09.014. Chem Biol. 2009. PMID: 19875084
Insights into the evolution of macrolactam biosynthesis through cloning and comparative analysis of the biosynthetic gene cluster for a novel macrocyclic lactam, ML-449.
Jørgensen H, Degnes KF, Dikiy A, Fjaervik E, Klinkenberg G, Zotchev SB. Jørgensen H, et al. Among authors: zotchev sb. Appl Environ Microbiol. 2010 Jan;76(1):283-93. doi: 10.1128/AEM.00744-09. Epub 2009 Oct 23. Appl Environ Microbiol. 2010. PMID: 19854930 Free PMC article.
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