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Glucose- and interleukin-1beta-induced beta-cell apoptosis requires Ca2+ influx and extracellular signal-regulated kinase (ERK) 1/2 activation and is prevented by a sulfonylurea receptor 1/inwardly rectifying K+ channel 6.2 (SUR/Kir6.2) selective potassium channel opener in human islets.
Maedler K, Størling J, Sturis J, Zuellig RA, Spinas GA, Arkhammar PO, Mandrup-Poulsen T, Donath MY. Maedler K, et al. Among authors: zuellig ra. Diabetes. 2004 Jul;53(7):1706-13. doi: 10.2337/diabetes.53.7.1706. Diabetes. 2004. PMID: 15220194
Sulfonylurea induced beta-cell apoptosis in cultured human islets.
Maedler K, Carr RD, Bosco D, Zuellig RA, Berney T, Donath MY. Maedler K, et al. Among authors: zuellig ra. J Clin Endocrinol Metab. 2005 Jan;90(1):501-6. doi: 10.1210/jc.2004-0699. Epub 2004 Oct 13. J Clin Endocrinol Metab. 2005. PMID: 15483097
Superiority of small islets in human islet transplantation.
Lehmann R, Zuellig RA, Kugelmeier P, Baenninger PB, Moritz W, Perren A, Clavien PA, Weber M, Spinas GA. Lehmann R, et al. Among authors: zuellig ra. Diabetes. 2007 Mar;56(3):594-603. doi: 10.2337/db06-0779. Diabetes. 2007. PMID: 17327426 Clinical Trial.
38 results