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The thymic epithelial microRNA network elevates the threshold for infection-associated thymic involution via miR-29a mediated suppression of the IFN-α receptor.
Papadopoulou AS, Dooley J, Linterman MA, Pierson W, Ucar O, Kyewski B, Zuklys S, Hollander GA, Matthys P, Gray DH, De Strooper B, Liston A. Papadopoulou AS, et al. Among authors: zuklys s. Nat Immunol. 2011 Dec 18;13(2):181-7. doi: 10.1038/ni.2193. Nat Immunol. 2011. PMID: 22179202 Free PMC article.
Thymic cysts originate from Foxn1 positive thymic medullary epithelium.
Vroegindeweij E, Crobach S, Itoi M, Satoh R, Zuklys S, Happe C, Germeraad WT, Cornelissen JJ, Cupedo T, Holländer GA, Kawamoto H, van Ewijk W. Vroegindeweij E, et al. Among authors: zuklys s. Mol Immunol. 2010 Feb;47(5):1106-13. doi: 10.1016/j.molimm.2009.10.034. Epub 2009 Nov 27. Mol Immunol. 2010. PMID: 19945167
MicroRNAs control the maintenance of thymic epithelia and their competence for T lineage commitment and thymocyte selection.
Zuklys S, Mayer CE, Zhanybekova S, Stefanski HE, Nusspaumer G, Gill J, Barthlott T, Chappaz S, Nitta T, Dooley J, Nogales-Cadenas R, Takahama Y, Finke D, Liston A, Blazar BR, Pascual-Montano A, Holländer GA. Zuklys S, et al. J Immunol. 2012 Oct 15;189(8):3894-904. doi: 10.4049/jimmunol.1200783. Epub 2012 Sep 12. J Immunol. 2012. PMID: 22972926 Free PMC article.
TRAF3 enforces the requirement for T cell cross-talk in thymic medullary epithelial development.
Jenkinson SR, Williams JA, Jeon H, Zhang J, Nitta T, Ohigashi I, Kruhlak M, Zuklys S, Sharrow S, Adams A, Granger L, Choi Y, Siebenlist U, Bishop GA, Hollander GA, Takahama Y, Hodes RJ. Jenkinson SR, et al. Among authors: zuklys s. Proc Natl Acad Sci U S A. 2013 Dec 24;110(52):21107-12. doi: 10.1073/pnas.1314859111. Epub 2013 Dec 9. Proc Natl Acad Sci U S A. 2013. PMID: 24324158 Free PMC article.
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