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Class effects of SGLT2 inhibitors in mouse cardiomyocytes and hearts: inhibition of Na+/H+ exchanger, lowering of cytosolic Na+ and vasodilation.
Uthman L, Baartscheer A, Bleijlevens B, Schumacher CA, Fiolet JWT, Koeman A, Jancev M, Hollmann MW, Weber NC, Coronel R, Zuurbier CJ. Uthman L, et al. Among authors: zuurbier cj. Diabetologia. 2018 Mar;61(3):722-726. doi: 10.1007/s00125-017-4509-7. Epub 2017 Dec 2. Diabetologia. 2018. PMID: 29197997 Free PMC article.
Empagliflozin Decreases Lactate Generation in an NHE-1 Dependent Fashion and Increases α-Ketoglutarate Synthesis From Palmitate in Type II Diabetic Mouse Hearts.
Zhang H, Uthman L, Bakker D, Sari S, Chen S, Hollmann MW, Coronel R, Weber NC, Houten SM, van Weeghel M, Zuurbier CJ. Zhang H, et al. Among authors: zuurbier cj. Front Cardiovasc Med. 2020 Dec 4;7:592233. doi: 10.3389/fcvm.2020.592233. eCollection 2020. Front Cardiovasc Med. 2020. PMID: 33344518 Free PMC article.
Empagliflozin reduces oxidative stress through inhibition of the novel inflammation/NHE/[Na+]c/ROS-pathway in human endothelial cells.
Uthman L, Li X, Baartscheer A, Schumacher CA, Baumgart P, Hermanides J, Preckel B, Hollmann MW, Coronel R, Zuurbier CJ, Weber NC. Uthman L, et al. Among authors: zuurbier cj. Biomed Pharmacother. 2022 Feb;146:112515. doi: 10.1016/j.biopha.2021.112515. Epub 2021 Dec 9. Biomed Pharmacother. 2022. PMID: 34896968 Free article.
Direct cardiac effects of SGLT2 inhibitors.
Chen S, Coronel R, Hollmann MW, Weber NC, Zuurbier CJ. Chen S, et al. Among authors: zuurbier cj. Cardiovasc Diabetol. 2022 Mar 18;21(1):45. doi: 10.1186/s12933-022-01480-1. Cardiovasc Diabetol. 2022. PMID: 35303888 Free PMC article. Review.
121 results