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13C isotopomer analysis of glucose and alanine metabolism reveals cytosolic pyruvate compartmentation as part of energy metabolism in astrocytes.
Zwingmann C, Richter-Landsberg C, Leibfritz D. Zwingmann C, et al. Glia. 2001 May;34(3):200-12. doi: 10.1002/glia.1054. Glia. 2001. PMID: 11329182
After incubation of glial cells with both (13)C-labeled and unlabeled glucose and alanine, (13)C isotopomer analysis indicates two cytosolic pyruvate compartments in astrocytes. ...
After incubation of glial cells with both (13)C-labeled and unlabeled glucose and alanine, (13)C isotopomer analysis indicates …
Contribution of extracellular glutamine as an anaplerotic substrate to neuronal metabolism: a re-evaluation by multinuclear NMR spectroscopy in primary cultured neurons.
Shokati T, Zwingmann C, Leibfritz D. Shokati T, et al. Neurochem Res. 2005 Oct;30(10):1269-81. doi: 10.1007/s11064-005-8798-8. Neurochem Res. 2005. PMID: 16341588
Ammonia toxicity under hyponatremic conditions in astrocytes: de novo synthesis of amino acids for the osmoregulatory response.
Zwingmann C, Leibfritz D. Zwingmann C, et al. Neurochem Int. 2005 Jul;47(1-2):39-50. doi: 10.1016/j.neuint.2005.04.005. Neurochem Int. 2005. PMID: 15908044
Multinuclear (1H-, 31P-, 13C-) NMR spectra were recorded to quantify water-soluble metabolites, the cellular energy state, as well as the incorporation of [1-(13)C]glucose into amino acids of primary astrocyte cultures. ...
Multinuclear (1H-, 31P-, 13C-) NMR spectra were recorded to quantify water-soluble metabolites, the cellular energy state, as well as the in …
MRL/lpr mice have alterations in brain metabolism as shown with [1H-13C] NMR spectroscopy.
Alexander JJ, Zwingmann C, Quigg R. Alexander JJ, et al. Neurochem Int. 2005 Jul;47(1-2):143-51. doi: 10.1016/j.neuint.2005.04.016. Neurochem Int. 2005. PMID: 15893408
Furthermore, 13C isotopomer analysis showed a selective increase of de novo synthesis of lactate from [1-(13)C] glucose through glycolysis resulting in 1.5-fold increased fractional 13C enrichments in lactate in MRL/lpr mice. [4-(13)C] Glutamate, which is synthesize …
Furthermore, 13C isotopomer analysis showed a selective increase of de novo synthesis of lactate from [1-(13)C] glucose through glyco …
Regulation of glial metabolism studied by 13C-NMR.
Zwingmann C, Leibfritz D. Zwingmann C, et al. NMR Biomed. 2003 Oct-Nov;16(6-7):370-99. doi: 10.1002/nbm.850. NMR Biomed. 2003. PMID: 14679501 Review.
Ex vivo and in vitro (13)C-NMR spectroscopy have been used to monitor neural cellular and tissue metabolism. Special emphasis has been given to the metabolic specialization of astrocytes and its enzymatic regulation. ...These in vitro studies using (13)C-NMR spectro …
Ex vivo and in vitro (13)C-NMR spectroscopy have been used to monitor neural cellular and tissue metabolism. Special emphasis has bee …
Nmr spectroscopic analysis of regional brain energy metabolism in manganese neurotoxicity.
Zwingmann C, Leibfritz D, Hazell AS. Zwingmann C, et al. Glia. 2007 Nov 15;55(15):1610-7. doi: 10.1002/glia.20575. Glia. 2007. PMID: 17823966
In the present study, we investigated specific pathways of [1-(13)C]glucose as well as of [2-(13)C]acetate in this brain region and the frontal cortex following 4-day manganese treatment by high-resolution NMR spectroscopy. ...In particular, decreased (13)C-l …
In the present study, we investigated specific pathways of [1-(13)C]glucose as well as of [2-(13)C]acetate in this brain regio …
Energy metabolism in astrocytes and neurons treated with manganese: relation among cell-specific energy failure, glucose metabolism, and intercellular trafficking using multinuclear NMR-spectroscopic analysis.
Zwingmann C, Leibfritz D, Hazell AS. Zwingmann C, et al. J Cereb Blood Flow Metab. 2003 Jun;23(6):756-71. doi: 10.1097/01.WCB.0000056062.25434.4D. J Cereb Blood Flow Metab. 2003. PMID: 12796724
Effects of ammonia exposition on glioma cells: changes in cell volume and organic osmolytes studied by diffusion-weighted and high-resolution NMR spectroscopy.
Zwingmann C, Flögel U, Pfeuffer J, Leibfritz D. Zwingmann C, et al. Dev Neurosci. 2000 Sep-Dec;22(5-6):463-71. doi: 10.1159/000017476. Dev Neurosci. 2000. PMID: 11111163
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