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769 results
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Page 1
Search for a crosslinker-based identification instead (1 results)
Protein-protein interactions identified by pull-down experiments and mass spectrometry.
Brymora A, Valova VA, Robinson PJ. Brymora A, et al. Curr Protoc Cell Biol. 2004 May;Chapter 17:Unit 17.5. doi: 10.1002/0471143030.cb1705s22. Curr Protoc Cell Biol. 2004. PMID: 18228443 Review.
The aim of this unit is to provide a method for the identification of new protein-protein interactions. Pull-down experiments with GST fusion proteins attached to glutathione beads are a screening technique for identification of protein-protein interactions. ...Appr …
The aim of this unit is to provide a method for the identification of new protein-protein interactions. Pull-down experiments with GS …
MSFragger: ultrafast and comprehensive peptide identification in mass spectrometry-based proteomics.
Kong AT, Leprevost FV, Avtonomov DM, Mellacheruvu D, Nesvizhskii AI. Kong AT, et al. Nat Methods. 2017 May;14(5):513-520. doi: 10.1038/nmeth.4256. Epub 2017 Apr 10. Nat Methods. 2017. PMID: 28394336 Free PMC article.
There is a need to better understand and handle the 'dark matter' of proteomics-the vast diversity of post-translational and chemical modifications that are unaccounted in a typical mass spectrometry-based analysis and thus remain unidentified. We present a fragment-ion in …
There is a need to better understand and handle the 'dark matter' of proteomics-the vast diversity of post-translational and chemical modifi …
Elastin.
Mithieux SM, Weiss AS. Mithieux SM, et al. Adv Protein Chem. 2005;70:437-61. doi: 10.1016/S0065-3233(05)70013-9. Adv Protein Chem. 2005. PMID: 15837523 Review.
Tropoelastin associates with multiple tropoelastin molecules during the major phase of elastogenesis through coacervation, where this process is directed by the precise patterning of mostly alternating hydrophobic and hydrophilic sequences that dictate intermolecular alignment. M …
Tropoelastin associates with multiple tropoelastin molecules during the major phase of elastogenesis through coacervation, where this proces …
Transcriptome-wide identification of RNA-binding protein and microRNA target sites by PAR-CLIP.
Hafner M, Landthaler M, Burger L, Khorshid M, Hausser J, Berninger P, Rothballer A, Ascano M Jr, Jungkamp AC, Munschauer M, Ulrich A, Wardle GS, Dewell S, Zavolan M, Tuschl T. Hafner M, et al. Cell. 2010 Apr 2;141(1):129-41. doi: 10.1016/j.cell.2010.03.009. Cell. 2010. PMID: 20371350 Free PMC article.
RNA transcripts are subject to posttranscriptional gene regulation involving hundreds of RNA-binding proteins (RBPs) and microRNA-containing ribonucleoprotein complexes (miRNPs) expressed in a cell-type dependent fashion. We developed a cell-based crosslinking appro …
RNA transcripts are subject to posttranscriptional gene regulation involving hundreds of RNA-binding proteins (RBPs) and microRNA-containing …
A crosslinker-based identification of redox relay targets.
Araki K, Ushioda R, Kusano H, Tanaka R, Hatta T, Fukui K, Nagata K, Natsume T. Araki K, et al. Anal Biochem. 2017 Mar 1;520:22-26. doi: 10.1016/j.ab.2016.12.025. Epub 2016 Dec 31. Anal Biochem. 2017. PMID: 28048978
Thiol-based redox control is among the most important mechanisms for maintaining cellular redox homeostasis, with essential participation of cysteine thiols of oxidoreductases. To explore cellular redox regulatory networks, direct interactions among active cysteine thiols …
Thiol-based redox control is among the most important mechanisms for maintaining cellular redox homeostasis, with essential participa …
A Photoaffinity-Based Fragment-Screening Platform for Efficient Identification of Protein Ligands.
Grant EK, Fallon DJ, Hann MM, Fantom KGM, Quinn C, Zappacosta F, Annan RS, Chung CW, Bamborough P, Dixon DP, Stacey P, House D, Patel VK, Tomkinson NCO, Bush JT. Grant EK, et al. Angew Chem Int Ed Engl. 2020 Nov 16;59(47):21096-21105. doi: 10.1002/anie.202008361. Epub 2020 Sep 7. Angew Chem Int Ed Engl. 2020. PMID: 32745361 Free article.
Advances in genomic analyses enable the identification of new proteins that are associated with disease. To validate these targets, tool molecules are required to demonstrate that a ligand can have a disease-modifying effect. ...Hits can be profiled to determine potency an …
Advances in genomic analyses enable the identification of new proteins that are associated with disease. To validate these targets, t …
Target identification of small molecules based on chemical biology approaches.
Futamura Y, Muroi M, Osada H. Futamura Y, et al. Mol Biosyst. 2013 May;9(5):897-914. doi: 10.1039/c2mb25468a. Mol Biosyst. 2013. PMID: 23354001 Review.
Recently, a phenotypic approach-screens that assess the effects of compounds on cells, tissues, or whole organisms-has been reconsidered and reintroduced as a complementary strategy of a target-based approach for drug discovery. Although the finding of novel bioactive comp …
Recently, a phenotypic approach-screens that assess the effects of compounds on cells, tissues, or whole organisms-has been reconsidered and …
A microwave-based technique as a feasible method to detect plastic pollutants in experimental samples.
VishnuRadhan R, Lonappan A, Eldho TI. VishnuRadhan R, et al. J Hazard Mater. 2022 Apr 15;428:128224. doi: 10.1016/j.jhazmat.2022.128224. Epub 2022 Jan 5. J Hazard Mater. 2022. PMID: 35063835
The promising practices are often destructive, rendering the samples inutile for further investigations. In this paper, a technique based on the measurement of the dielectric properties of the samples, carried out using the rectangular cavity perturbation technique at the …
The promising practices are often destructive, rendering the samples inutile for further investigations. In this paper, a technique based
Intracellular proteome compartmentalization: a biotin ligase-based proximity labeling approach.
Durojaye OA. Durojaye OA. Cell Biosci. 2021 Aug 23;11(1):165. doi: 10.1186/s13578-021-00666-6. Cell Biosci. 2021. PMID: 34425888 Free PMC article.
Furthermore, the identification of interacting proteins is also crucial for the elucidation of the underlying mechanism of complex cellular processes. ...Furthermore, contamination that leads to the identification of false positive is widespread even when purificati …
Furthermore, the identification of interacting proteins is also crucial for the elucidation of the underlying mechanism of complex ce …
Mass spectrometry-based methods for structural biology on a proteome-wide scale.
Jones LM. Jones LM. Biochem Soc Trans. 2020 Jun 30;48(3):945-954. doi: 10.1042/BST20190794. Biochem Soc Trans. 2020. PMID: 32412054 Review.
Mass spectrometry (MS) has long been used to study proteins mainly via sequence identification and quantitation of expression abundance. In recent years, MS has emerged as a tool for structural biology. ...This mini-review discusses the various MS-based methods that …
Mass spectrometry (MS) has long been used to study proteins mainly via sequence identification and quantitation of expression abundan …
769 results