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654 results
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Page 1
Search for a crosslinker-based identification instead (1 results)
Protein-protein interactions identified by pull-down experiments and mass spectrometry.
Brymora A, Valova VA, Robinson PJ. Brymora A, et al. Curr Protoc Cell Biol. 2004 May;Chapter 17:Unit 17.5. doi: 10.1002/0471143030.cb1705s22. Curr Protoc Cell Biol. 2004. PMID: 18228443 Review.
The aim of this unit is to provide a method for the identification of new protein-protein interactions. Pull-down experiments with GST fusion proteins attached to glutathione beads are a screening technique for identification of protein-protein interactions. ...Appr …
The aim of this unit is to provide a method for the identification of new protein-protein interactions. Pull-down experiments with GS …
MSFragger: ultrafast and comprehensive peptide identification in mass spectrometry-based proteomics.
Kong AT, Leprevost FV, Avtonomov DM, Mellacheruvu D, Nesvizhskii AI. Kong AT, et al. Nat Methods. 2017 May;14(5):513-520. doi: 10.1038/nmeth.4256. Epub 2017 Apr 10. Nat Methods. 2017. PMID: 28394336 Free PMC article.
There is a need to better understand and handle the 'dark matter' of proteomics-the vast diversity of post-translational and chemical modifications that are unaccounted in a typical mass spectrometry-based analysis and thus remain unidentified. We present a fragment-ion in …
There is a need to better understand and handle the 'dark matter' of proteomics-the vast diversity of post-translational and chemical modifi …
Elastin.
Mithieux SM, Weiss AS. Mithieux SM, et al. Adv Protein Chem. 2005;70:437-61. doi: 10.1016/S0065-3233(05)70013-9. Adv Protein Chem. 2005. PMID: 15837523 Review.
Tropoelastin associates with multiple tropoelastin molecules during the major phase of elastogenesis through coacervation, where this process is directed by the precise patterning of mostly alternating hydrophobic and hydrophilic sequences that dictate intermolecular alignment. M …
Tropoelastin associates with multiple tropoelastin molecules during the major phase of elastogenesis through coacervation, where this proces …
Transcriptome-wide identification of RNA-binding protein and microRNA target sites by PAR-CLIP.
Hafner M, Landthaler M, Burger L, Khorshid M, Hausser J, Berninger P, Rothballer A, Ascano M Jr, Jungkamp AC, Munschauer M, Ulrich A, Wardle GS, Dewell S, Zavolan M, Tuschl T. Hafner M, et al. Cell. 2010 Apr 2;141(1):129-41. doi: 10.1016/j.cell.2010.03.009. Cell. 2010. PMID: 20371350 Free PMC article.
RNA transcripts are subject to posttranscriptional gene regulation involving hundreds of RNA-binding proteins (RBPs) and microRNA-containing ribonucleoprotein complexes (miRNPs) expressed in a cell-type dependent fashion. We developed a cell-based crosslinking appro …
RNA transcripts are subject to posttranscriptional gene regulation involving hundreds of RNA-binding proteins (RBPs) and microRNA-containing …
A Photoaffinity-Based Fragment-Screening Platform for Efficient Identification of Protein Ligands.
Grant EK, Fallon DJ, Hann MM, Fantom KGM, Quinn C, Zappacosta F, Annan RS, Chung CW, Bamborough P, Dixon DP, Stacey P, House D, Patel VK, Tomkinson NCO, Bush JT. Grant EK, et al. Angew Chem Int Ed Engl. 2020 Nov 16;59(47):21096-21105. doi: 10.1002/anie.202008361. Epub 2020 Sep 7. Angew Chem Int Ed Engl. 2020. PMID: 32745361
Advances in genomic analyses enable the identification of new proteins that are associated with disease. To validate these targets, tool molecules are required to demonstrate that a ligand can have a disease-modifying effect. ...Hits can be profiled to determine potency an …
Advances in genomic analyses enable the identification of new proteins that are associated with disease. To validate these targets, t …
A crosslinker-based identification of redox relay targets.
Araki K, Ushioda R, Kusano H, Tanaka R, Hatta T, Fukui K, Nagata K, Natsume T. Araki K, et al. Anal Biochem. 2017 Mar 1;520:22-26. doi: 10.1016/j.ab.2016.12.025. Epub 2016 Dec 31. Anal Biochem. 2017. PMID: 28048978
Thiol-based redox control is among the most important mechanisms for maintaining cellular redox homeostasis, with essential participation of cysteine thiols of oxidoreductases. To explore cellular redox regulatory networks, direct interactions among active cysteine thiols …
Thiol-based redox control is among the most important mechanisms for maintaining cellular redox homeostasis, with essential participa …
Identification of IgE.
Ishizaka K, Ishizaka T. Ishizaka K, et al. J Allergy Clin Immunol. 2016 Jun;137(6):1646-1650. doi: 10.1016/j.jaci.2015.12.1343. Epub 2016 Apr 15. J Allergy Clin Immunol. 2016. PMID: 27090936 Free article. Review.
Our studies were based on the hypothesis that reaginic antibody activity is associated with a unique immunoglobulin isotype, which is now called IgE. As expected, identification of IgE facilitated the analysis of immunologic mechanisms of reaginic hypersensitivity. …
Our studies were based on the hypothesis that reaginic antibody activity is associated with a unique immunoglobulin isotype, which is …
Development of a novel cross-linking strategy for fast and accurate identification of cross-linked peptides of protein complexes.
Kao A, Chiu CL, Vellucci D, Yang Y, Patel VR, Guan S, Randall A, Baldi P, Rychnovsky SD, Huang L. Kao A, et al. Mol Cell Proteomics. 2011 Jan;10(1):M110.002212. doi: 10.1074/mcp.M110.002212. Epub 2010 Aug 24. Mol Cell Proteomics. 2011. PMID: 20736410 Free PMC article.
DSSO contains two symmetric collision-induced dissociation (CID)-cleavable sites that allow effective identification of DSSO-cross-linked peptides based on their distinct fragmentation patterns unique to cross-linking types (i.e. interlink, intralink, and dead end). …
DSSO contains two symmetric collision-induced dissociation (CID)-cleavable sites that allow effective identification of DSSO-cross-li …
Identification, characterization, and immobilization of a novel YbfF esterase from Halomonas elongata.
Yoo W, Kim B, Jeon S, Kim KK, Kim TD. Yoo W, et al. Int J Biol Macromol. 2020 Dec 15;165(Pt A):1139-1148. doi: 10.1016/j.ijbiomac.2020.09.247. Epub 2020 Oct 6. Int J Biol Macromol. 2020. PMID: 33031847
Based on a homology model of YbfF(H.elongata), Trp(237) in the substrate-binding pocket, a critical residue for catalytic activity and substrate specificity was identified and characterized. Furthermore, crosslinked enzyme aggregates and nanoflower formation were ex
Based on a homology model of YbfF(H.elongata), Trp(237) in the substrate-binding pocket, a critical residue for catalytic activity an
Fragment-Based Identification of Ligands for Bromodomain-Containing Factor 3 of Trypanosoma cruzi.
Laurin CMC, Bluck JP, Chan AKN, Keller M, Boczek A, Scorah AR, See KFL, Jennings LE, Hewings DS, Woodhouse F, Reynolds JK, Schiedel M, Humphreys PG, Biggin PC, Conway SJ. Laurin CMC, et al. ACS Infect Dis. 2020 Nov 17. doi: 10.1021/acsinfecdis.0c00618. Online ahead of print. ACS Infect Dis. 2020. PMID: 33203208
However, little is known about the function of the TcBDF1-5. Here we describe a fragment-based approach to identify ligands for T. cruzi bromodomain-containing factor 3 (TcBDF3). ...On the basis of this screen, we developed functional ligands containing a fluorescence or ( …
However, little is known about the function of the TcBDF1-5. Here we describe a fragment-based approach to identify ligands for T. cr …
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