Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My Custom Filters

Edit custom filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1995 1
2003 1
2007 1
2010 1
2015 1
2016 1
2017 1
2019 1
2020 1
2021 1
2022 1
2023 2
2024 1
2025 2
2026 0

Publication date

Text availability

Article attribute

Article type

Additional filters

Article Language

Species

Sex

Age

Other

Search Results

14 results

Results by year

Filters applied: . Clear all
Page 1
Stimulation of Dentin Regeneration by Using Acemannan in Teeth with Lipopolysaccharide-induced Pulp Inflammation.
Songsiripradubboon S, Kladkaew S, Trairatvorakul C, Sangvanich P, Soontornvipart K, Banlunara W, Thunyakitpisal P. Songsiripradubboon S, et al. J Endod. 2017 Jul;43(7):1097-1103. doi: 10.1016/j.joen.2017.01.037. Epub 2017 May 3. J Endod. 2017. PMID: 28477996
In vivo, partial pulpotomy treatment using acemannan generated outcomes similar to mineral trioxide aggregate treatment, resulting in mineralized bridge formation with normal pulp tissue without inflammation or pulp necrosis. In contrast, the formocresol group demon …
In vivo, partial pulpotomy treatment using acemannan generated outcomes similar to mineral trioxide aggregate treatment, resulting in …
Pharmacodynamics of Aloe vera and acemannan in therapeutic applications for skin, digestion, and immunomodulation.
Sadgrove NJ, Simmonds MSJ. Sadgrove NJ, et al. Phytother Res. 2021 Dec;35(12):6572-6584. doi: 10.1002/ptr.7242. Epub 2021 Aug 24. Phytother Res. 2021. PMID: 34427371 Review.
In the colon, acemannan is digested by microbes into short-chain fatty acids that are absorbed and augment the sensation of satiety and confer a host of other health benefits. ...This causes M2 polarisation, reversal of inflammation, and acceleration of the re-epith …
In the colon, acemannan is digested by microbes into short-chain fatty acids that are absorbed and augment the sensation of satiety a …
Exploring acemannan-loaded nanogel formulation for the treatment of IMQ-induced psoriasis-like inflammation: In vitro characterization and in vivo efficacy assessment.
Alqarni SS, Afzal M, Al-Abbasi FA, Moglad E, Bawadood AS, Almalki NAR, Alqurashi MM, Imam F, Syed SM, Kazmi I. Alqarni SS, et al. Int Immunopharmacol. 2025 Feb 20;148:114064. doi: 10.1016/j.intimp.2025.114064. Epub 2025 Jan 29. Int Immunopharmacol. 2025. PMID: 39884082
This study aimed to explore a nanogel formulation containing acemannan as a carrier for the treatment of psoriasis-like skin inflammation. Several acemannan concentrations, such as F1 (2.5 %) and F2 (5 %), were used to prepare the nanogel formulation by homog …
This study aimed to explore a nanogel formulation containing acemannan as a carrier for the treatment of psoriasis-like skin infla …
Acemannan, an extracted product from Aloe vera, stimulates dental pulp cell proliferation, differentiation, mineralization, and dentin formation.
Jittapiromsak N, Sahawat D, Banlunara W, Sangvanich P, Thunyakitpisal P. Jittapiromsak N, et al. Tissue Eng Part A. 2010 Jun;16(6):1997-2006. doi: 10.1089/ten.TEA.2009.0593. Tissue Eng Part A. 2010. PMID: 20088703
This study investigated the effect of acemannan (Aloe vera gel polysaccharide) on dentin formation. Primary human dental pulp cells were treated with acemannan. ...In the acemannan-treated group, either mild or no inflammation was found, whereas the ot …
This study investigated the effect of acemannan (Aloe vera gel polysaccharide) on dentin formation. Primary human dental pulp cells w …
Alginate/acemannan-based beads loaded with a biocompatible ionic liquid as a bioactive delivery system.
Gomes JM, Silva SS, Rodrigues LC, Reis RL. Gomes JM, et al. Int J Biol Macromol. 2023 Jul 1;242(Pt 3):125026. doi: 10.1016/j.ijbiomac.2023.125026. Epub 2023 May 25. Int J Biol Macromol. 2023. PMID: 37244345
The current study investigates the potential of cholinium caffeate (Ch[Caffeate]), a phenolic-based biocompatible ionic liquid (Bio-IL) entrapped in alginate/acemannan beads, as a drug delivery system able to reduce local joint inflammation on osteoarthritis (OA) tr …
The current study investigates the potential of cholinium caffeate (Ch[Caffeate]), a phenolic-based biocompatible ionic liquid (Bio-IL) entr …
Preventive effect of acemannan on DMBA-induced mouse skin tumorigenesis by modulating inflammatory cytokines and apoptosis pathways: molecular docking and molecular dynamic simulation approaches.
Alzarea AI, Zafar A, Alsaidan OA, Alanazi AS, Alzarea SI, Alhassan HH, Uttekar PS. Alzarea AI, et al. Int J Biol Macromol. 2025 Jun;311(Pt 4):143836. doi: 10.1016/j.ijbiomac.2025.143836. Epub 2025 May 1. Int J Biol Macromol. 2025. PMID: 40318716
This study investigated the therapeutic potential of acemannan against 7,12-dimethylbenz[a]anthracene (DMBA)-evoked skin cancer in mice. Mice were randomly divided (n = 6): a control (group I), DMBA-induced cancer (group II), and two treatment groups (group III & IV) t …
This study investigated the therapeutic potential of acemannan against 7,12-dimethylbenz[a]anthracene (DMBA)-evoked skin cancer in mi …
Aloe polymeric acemannan inhibits the cytokine storm in mouse pneumonia models by modulating macrophage metabolism.
Li L, Xu W, Luo Y, Lao C, Tong X, Du J, Huang B, Li D, Chen J, Ye H, Cong F, Guo X, Li J. Li L, et al. Carbohydr Polym. 2022 Dec 1;297:120032. doi: 10.1016/j.carbpol.2022.120032. Epub 2022 Aug 27. Carbohydr Polym. 2022. PMID: 36184177
Plant polysaccharides, the main natural phytomedicine source, have a great potential to be an effective drug to treat cytokine storm. Herein we found that a polymeric acemannan (ABPA1) isolated from Aloe Vera Barbadensis extract C (AVBEC) exerted prominent inhibitory effec …
Plant polysaccharides, the main natural phytomedicine source, have a great potential to be an effective drug to treat cytokine storm. Herein …
The effect of Acemannan Immunostimulant in combination with surgery and radiation therapy on spontaneous canine and feline fibrosarcomas.
King GK, Yates KM, Greenlee PG, Pierce KR, Ford CR, McAnalley BH, Tizard IR. King GK, et al. J Am Anim Hosp Assoc. 1995 Sep-Oct;31(5):439-47. doi: 10.5326/15473317-31-5-439. J Am Anim Hosp Assoc. 1995. PMID: 8542364 Clinical Trial.
Following four to seven weekly acemannan treatments, tumor shrinkage occurred in four (greater than 50%; n = 2) of 12 animals, with tumors accessible to measurement. A notable increase in necrosis and inflammation was observed. Complete surgical excision was perform …
Following four to seven weekly acemannan treatments, tumor shrinkage occurred in four (greater than 50%; n = 2) of 12 animals, with t …
Evaluation of hydrophilic gel made from Acemannan and Moringa oleifera in enhancing osseointegration of dental implants. A preliminary study in rabbits.
Pachimalla PR, Mishra SK, Chowdhary R. Pachimalla PR, et al. J Oral Biol Craniofac Res. 2020 Apr-Jun;10(2):13-19. doi: 10.1016/j.jobcr.2020.01.005. Epub 2020 Jan 23. J Oral Biol Craniofac Res. 2020. PMID: 32025481 Free PMC article.
RESULTS: The alkaline phosphatase assay showed least cell inhibition for Acemannan and Moringa oleifera (2:1) as 4.45% and osteoblastic differentiation as 0.328 at 540 nm. ...CONCLUSIONS: Hydrophilic implant surface showed new bone formation with increased bone to implant …
RESULTS: The alkaline phosphatase assay showed least cell inhibition for Acemannan and Moringa oleifera (2:1) as 4.45% and osteoblast …
Clinical, radiographic, and histologic analysis of the effects of acemannan used in direct pulp capping of human primary teeth: short-term outcomes.
Songsiripradubboon S, Banlunara W, Sangvanich P, Trairatvorakul C, Thunyakitpisal P. Songsiripradubboon S, et al. Odontology. 2016 Sep;104(3):329-37. doi: 10.1007/s10266-015-0215-4. Epub 2015 Aug 12. Odontology. 2016. PMID: 26264630 Clinical Trial.
The teeth due to exfoliate were extracted and histopathologically evaluated for inflammation, dentine bridge formation, and soft tissue organization. At 6 months, the overall clinical and radiographic success rates of direct pulp capping with acemannan and calcium h …
The teeth due to exfoliate were extracted and histopathologically evaluated for inflammation, dentine bridge formation, and soft tiss …
14 results