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N-acetylcysteine amide, a promising antidote for acetaminophen toxicity.
Khayyat A, Tobwala S, Hart M, Ercal N. Khayyat A, et al. Toxicol Lett. 2016 Jan 22;241:133-42. doi: 10.1016/j.toxlet.2015.11.008. Epub 2015 Nov 19. Toxicol Lett. 2016. PMID: 26602168
Acetaminophen (N-acetyl-p-aminophenol, APAP) is one of the most widely used over the counter antipyretic and analgesic medications. ...Depletion of glutathione (GSH) is one of the initiating steps in APAP-induced hepatotoxicity; therefore, one strategy for restricti …
Acetaminophen (N-acetyl-p-aminophenol, APAP) is one of the most widely used over the counter antipyretic and analgesic medicat …
Evaluation of N-acetylcysteine dose for the treatment of massive acetaminophen ingestion.
Lewis JC, Lim M, Lai L, Mendoza E, Albertson TE, Chenoweth JA. Lewis JC, et al. Clin Toxicol (Phila). 2022 Apr;60(4):507-513. doi: 10.1080/15563650.2021.1984503. Epub 2021 Sep 28. Clin Toxicol (Phila). 2022. PMID: 34581655
METHODS: The use of N-acetylcysteine (NAC) remains the standard of care for treatment of acetaminophen (APAP) toxicity and overdose. Currently, there is growing evidence to suggest that massive acetaminophen overdose is associated with increased …
METHODS: The use of N-acetylcysteine (NAC) remains the standard of care for treatment of acetaminophen (APAP) toxici …
The combination of N-acetylcysteine and cyclosporin A reduces acetaminophen-induced hepatotoxicity in mice.
Kaya Tektemur N, Erdem Güzel E, Gül M, Tektemur A, Özcan Yıldırım S, Kavak Balgetir M, Ozan Kocamüftüoğlu G, Yalçın T, Enver Ozan İ. Kaya Tektemur N, et al. Ultrastruct Pathol. 2021 Jan 2;45(1):19-27. doi: 10.1080/01913123.2020.1850964. Epub 2021 Feb 2. Ultrastruct Pathol. 2021. PMID: 33530839
Acetaminophen (APAP)-induced hepatotoxicity is the most common cause of acute liver failure in worldwide. ...We suggest that the combination of NAC and CsA reduces acetaminophen-induced hepatotoxicity in mice....
Acetaminophen (APAP)-induced hepatotoxicity is the most common cause of acute liver failure in worldwide. ...We suggest that the comb …
Evaluation of Dosing Strategies of N-acetylcysteine for Acetaminophen Toxicity in Patients Greater than 100 Kilograms: Should the Dosage Cap Be Used?
Baum RA, Woolum JA, Bailey AM, Howell MM, Weant KA, Geraghty L, Mohan S, Webb AN, Su MK, Akpunonu P; Collaborators. Baum RA, et al. J Med Toxicol. 2021 Jul;17(3):241-249. doi: 10.1007/s13181-021-00822-x. Epub 2021 Apr 21. J Med Toxicol. 2021. PMID: 33884558 Free PMC article.
INTRODUCTION: Acetaminophen is a commonly used analgesic and antipyretic, with the potential to cause significant injury when ingested in toxic amounts. Although the antidote n-acetylcysteine (NAC) is available, evidence supporting dose recommendations for pa …
INTRODUCTION: Acetaminophen is a commonly used analgesic and antipyretic, with the potential to cause significant injury when ingeste …
Molecular hydrogen mitigates acetaminophen-induced liver injury and enhances the effects of N-acetylcysteine in diabetic mice.
Kamimura N, Iuchi K, Igarashi T, Ohsawa I, Nito C, Usuda J, Ohta S. Kamimura N, et al. J Nutr Biochem. 2026 Mar;149:110176. doi: 10.1016/j.jnutbio.2025.110176. Epub 2025 Nov 7. J Nutr Biochem. 2026. PMID: 41207540 Free article.
Acetaminophen (APAP) overdose induces severe liver injury, especially in diabetic patients. N-acetylcysteine (NAC) is commonly used as an approved antidote for APAP toxicity; however, its narrow therapeutic window limits its clinical utility. ...
Acetaminophen (APAP) overdose induces severe liver injury, especially in diabetic patients. N-acetylcysteine (NAC) is c …
Cysteamine in combination with N-acetylcysteine prevents acetaminophen-induced hepatotoxicity.
Peterson TC, Brown IR. Peterson TC, et al. Can J Physiol Pharmacol. 1992 Jan;70(1):20-8. doi: 10.1139/y92-004. Can J Physiol Pharmacol. 1992. PMID: 1581851
N-Acetylcysteine (NAC) is protective against acetaminophen-induced hepatotoxicity primarily by providing precursor for the glutathione synthetase pathway, while cysteamine has been demonstrated to alter the cytochrome P-450 dependent formation of toxic ace …
N-Acetylcysteine (NAC) is protective against acetaminophen-induced hepatotoxicity primarily by providing precursor for …
Therapeutic effect of liposomal-N-acetylcysteine against acetaminophen-induced hepatotoxicity.
Alipour M, Buonocore C, Omri A, Szabo M, Pucaj K, Suntres ZE. Alipour M, et al. J Drug Target. 2013 May;21(5):466-73. doi: 10.3109/1061186X.2013.765443. Epub 2013 Apr 19. J Drug Target. 2013. PMID: 23600745
BACKGROUND: Acetaminophen (APAP) is an antipyretic analgesic drug that when taken in overdose causes depletion of glutathione (GSH) and hepatotoxicity. N-acetylcysteine (NAC) is the antidote of choice for the treatment of APAP toxicity; however, due to …
BACKGROUND: Acetaminophen (APAP) is an antipyretic analgesic drug that when taken in overdose causes depletion of glutathione (GSH) a …
Indocyanine green clearance varies as a function of N-acetylcysteine treatment in a murine model of acetaminophen toxicity.
Milesi-Hallé A, Abdel-Rahman SM, Brown A, McCullough SS, Letzig L, Hinson JA, James LP. Milesi-Hallé A, et al. Chem Biol Interact. 2011 Feb 1;189(3):222-9. doi: 10.1016/j.cbi.2010.12.001. Epub 2010 Dec 9. Chem Biol Interact. 2011. PMID: 21145883 Free PMC article.
Standard assays to assess acetaminophen (APAP) toxicity in animal models include determination of ALT (alanine aminotransferase) levels and examination of histopathology of liver sections. ...Toxicity (ALT values and histology) was significantly …
Standard assays to assess acetaminophen (APAP) toxicity in animal models include determination of ALT (alanine aminotra …
Is montelukast as effective as N-acetylcysteine in hepatic injury due to acetaminophen intoxication in rats?
İçer M, Zengin Y, Gunduz E, Dursun R, Durgun HM, Turkcu G, Yuksel H, Üstündağ M, Guloglu C. İçer M, et al. Exp Toxicol Pathol. 2016 Jan;68(1):55-9. doi: 10.1016/j.etp.2015.09.008. Epub 2015 Oct 14. Exp Toxicol Pathol. 2016. PMID: 26462568
The control group was administered oral distilled water 10 ml/kg, the APAP group oral APAP 1 g/kg, the montelukast sodium (MK) group oral MK 30 mg/kg, the acetaminophen+N-acetylcysteine (APAP+NAC) group oral APAP 1 g/kg, followed by a single dose of intraperi …
The control group was administered oral distilled water 10 ml/kg, the APAP group oral APAP 1 g/kg, the montelukast sodium (MK) group oral MK …
A Case Report of a Severe, Unusually Delayed Anaphylactoid Reaction to Intravenous N-Acetylcysteine During Treatment of Acute Acetaminophen Toxicity in an Adolescent.
Epperson LC, Weiss ST, Cao DJ. Epperson LC, et al. J Med Toxicol. 2021 Jan;17(1):75-79. doi: 10.1007/s13181-020-00804-5. Epub 2020 Aug 21. J Med Toxicol. 2021. PMID: 32821982 Free PMC article.
INTRODUCTION: Anaphylactoid reactions are well-documented adverse events associated with the intravenous administration of N-acetylcysteine (NAC) in patients with acetaminophen overdose. Most reactions are mild, occurring within the first 1-5 hours of initiat …
INTRODUCTION: Anaphylactoid reactions are well-documented adverse events associated with the intravenous administration of N-acety …
91 results