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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1963 2
1964 2
1966 3
1967 1
1968 1
1970 1
1971 1
1972 2
1973 3
1974 6
1975 9
1976 7
1977 5
1978 5
1979 2
1980 4
1981 8
1982 5
1983 9
1984 6
1985 9
1986 11
1987 7
1988 7
1989 14
1990 9
1991 12
1992 13
1993 15
1994 15
1995 13
1996 7
1997 10
1998 7
1999 7
2000 13
2001 15
2002 11
2003 3
2004 9
2005 15
2006 18
2007 14
2008 12
2009 20
2010 15
2011 17
2012 20
2013 11
2014 13
2015 14
2016 15
2017 17
2018 23
2019 20
2020 15
2021 22
2022 25
2023 23
2024 13

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588 results

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Page 1
Polyamine metabolism is a central determinant of helper T cell lineage fidelity.
Puleston DJ, Baixauli F, Sanin DE, Edwards-Hicks J, Villa M, Kabat AM, Kamiński MM, Stanckzak M, Weiss HJ, Grzes KM, Piletic K, Field CS, Corrado M, Haessler F, Wang C, Musa Y, Schimmelpfennig L, Flachsmann L, Mittler G, Yosef N, Kuchroo VK, Buescher JM, Balabanov S, Pearce EJ, Green DR, Pearce EL. Puleston DJ, et al. Cell. 2021 Aug 5;184(16):4186-4202.e20. doi: 10.1016/j.cell.2021.06.007. Epub 2021 Jul 2. Cell. 2021. PMID: 34216540 Free PMC article.
Here, we show that polyamine metabolism is a fundamental process governing the ability of CD4(+) helper T cells (T(H)) to polarize into different functional fates. Deficiency in ornithine decarboxylase, a crucial enzyme for polyamine synthesis, results in a severe failure …
Here, we show that polyamine metabolism is a fundamental process governing the ability of CD4(+) helper T cells (T(H)) to polarize into diff …
Functional Analysis of Feedback Inhibition-Insensitive Variants of N-Acetyl Glutamate Kinase Found in Sake Yeast Mutants with Ornithine Overproduction.
Ohashi M, Isogai S, Takagi H. Ohashi M, et al. Microbiol Spectr. 2022 Jun 29;10(3):e0082222. doi: 10.1128/spectrum.00822-22. Epub 2022 May 11. Microbiol Spectr. 2022. PMID: 35543513 Free PMC article.
In the yeast Saccharomyces cerevisiae, N-acetyl glutamate kinase (NAGK), which catalyzes the phosphorylation of N-acetyl glutamate to form N-acetyl glutamyl-5-phosphate, is one of the rate-limiting enzymes in the ornithine and arginine biosynthetic pat …
In the yeast Saccharomyces cerevisiae, N-acetyl glutamate kinase (NAGK), which catalyzes the phosphorylation of N-acetyl gluta …
Inhibitors of N(alpha)-acetyl-L-ornithine deacetylase: synthesis, characterization and analysis of their inhibitory potency.
Hlavácek J, Pícha J, Vanek V, Jirácek J, Slaninová J, Fucík V, Budĕsínský M, Gilner D, Holz RC. Hlavácek J, et al. Amino Acids. 2010 Apr;38(4):1155-64. doi: 10.1007/s00726-009-0326-8. Epub 2009 Aug 2. Amino Acids. 2010. PMID: 19649769
A series of N (alpha)-acyl (alkyl)- and N (alpha)-alkoxycarbonyl-derivatives of L- and D-ornithine were prepared, characterized, and analyzed for their potency toward the bacterial enzyme N (alpha)-acetyl-L-ornithine deacetylase (ArgE). ArgE catalyzes the con …
A series of N (alpha)-acyl (alkyl)- and N (alpha)-alkoxycarbonyl-derivatives of L- and D-ornithine were prepared, characterized, and …
N-acetyl ornithine deacetylase is a moonlighting protein and is involved in the adaptation of Entamoeba histolytica to nitrosative stress.
Shahi P, Trebicz-Geffen M, Nagaraja S, Hertz R, Baumel-Alterzon S, Methling K, Lalk M, Mazumder M, Samudrala G, Ankri S. Shahi P, et al. Sci Rep. 2016 Nov 3;6:36323. doi: 10.1038/srep36323. Sci Rep. 2016. PMID: 27808157 Free PMC article.
The transcriptome of NO adapted trophozoites (NAT) was investigated by RNA sequencing (RNA-seq). N-acetyl ornithine deacetylase (NAOD) was among the 208 genes that were upregulated in NAT. NAOD catalyzes the deacetylation of N-acetyl-L-ornithine to yie …
The transcriptome of NO adapted trophozoites (NAT) was investigated by RNA sequencing (RNA-seq). N-acetyl ornithine deacetylas …
Biochemical and structural basis of polyamine, lysine and ornithine acetylation catalyzed by spermine/spermidine N-acetyl transferase in moss and maize.
Bělíček J, Ľuptáková E, Kopečný D, Frömmel J, Vigouroux A, Ćavar Zeljković S, Jagic F, Briozzo P, Kopečný DJ, Tarkowski P, Nisler J, De Diego N, Moréra S, Kopečná M. Bělíček J, et al. Plant J. 2023 May;114(3):482-498. doi: 10.1111/tpj.16148. Epub 2023 Mar 16. Plant J. 2023. PMID: 36786691 Free article.
Two arginine residues, unique among plant SSATs, hold the carboxyl group of amino acid substrates. The most abundant acetylated compound accumulated in moss was N(6) -acetyl-Lys, whereas N(5) -acetyl-Orn, known to be toxic for aphids, was found in maize. Both …
Two arginine residues, unique among plant SSATs, hold the carboxyl group of amino acid substrates. The most abundant acetylated compo …
Glycerol Phenylbutyrate (Ravicti) [Internet].
[No authors listed] [No authors listed] Ottawa (ON): Canadian Agency for Drugs and Technologies in Health; 2017 Apr. Ottawa (ON): Canadian Agency for Drugs and Technologies in Health; 2017 Apr. PMID: 29381293 Free Books & Documents. Review.
Urea cycle disorders (UCDs) result from genetic mutations that cause defects in any of the five enzymes of the urea cycle in the liver: carbamoyl phosphate synthetase 1 (CPS1), ornithine transcarbamylase (OTC), argininosuccinate synthetase (ASS), argininosuccinate lyase, a …
Urea cycle disorders (UCDs) result from genetic mutations that cause defects in any of the five enzymes of the urea cycle in the liver: carb …
Evaluation of 2-acetyl-1-pyrroline in foods, with an emphasis on rice flavour.
Wei X, Handoko DD, Pather L, Methven L, Elmore JS. Wei X, et al. Food Chem. 2017 Oct 1;232:531-544. doi: 10.1016/j.foodchem.2017.04.005. Epub 2017 Apr 5. Food Chem. 2017. PMID: 28490108 Free article. Review.
The popcorn-like aroma compound 2-acetyl-1-pyrroline (2-AP) is a key contributor to the desirable aroma of fragrant rice and is also important in the aroma of other foods, such as pandan leaf, popcorn and Mediterranean sausage. ...This review examines the formation of 2-AP …
The popcorn-like aroma compound 2-acetyl-1-pyrroline (2-AP) is a key contributor to the desirable aroma of fragrant rice and is also …
Charge-mediated proteasome targeting.
Kudriaeva A, Kuzina ES, Zubenko O, Smirnov IV, Belogurov A Jr. Kudriaeva A, et al. FASEB J. 2019 Jun;33(6):6852-6866. doi: 10.1096/fj.201802237R. Epub 2019 Feb 27. FASEB J. 2019. PMID: 30811957
Ub-independent proteasome targeting is rationalized by the existence of 2 types of direct proteasome signals (DPSs), specific amino acid sequences or post-translational modifications, which are recognized by proteasome regulatory subunits. Historically, the first type was shown t …
Ub-independent proteasome targeting is rationalized by the existence of 2 types of direct proteasome signals (DPSs), specific amino acid seq …
Novel Therapies in Hepatic Encephalopathy.
Alimirah M, Sadiq O, Gordon SC. Alimirah M, et al. Clin Liver Dis. 2020 May;24(2):303-315. doi: 10.1016/j.cld.2020.01.009. Epub 2020 Mar 2. Clin Liver Dis. 2020. PMID: 32245535 Review.
Structural and biochemical analyses reveal how ornithine acetyl transferase binds acidic and basic amino acid substrates.
Iqbal A, Clifton IJ, Chowdhury R, Ivison D, Domene C, Schofield CJ. Iqbal A, et al. Org Biomol Chem. 2011 Sep 21;9(18):6219-25. doi: 10.1039/c1ob05554b. Epub 2011 Jul 28. Org Biomol Chem. 2011. PMID: 21796301
Structural and biochemical analyses reveal how ornithine acetyl-transferases catalyse the reversible transfer of an acetyl-group from a basic (ornithine) to an acidic (glutamate) amino acid by employing a common mechanism involving an acetyl-enz …
Structural and biochemical analyses reveal how ornithine acetyl-transferases catalyse the reversible transfer of an acetyl
588 results