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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1903 1
1906 1
1907 1
1910 1
1912 1
1921 1
1922 1
1923 1
1926 3
1927 3
1928 1
1929 1
1931 1
1932 1
1933 2
1934 5
1935 5
1936 3
1937 3
1938 5
1939 6
1940 3
1941 4
1942 1
1943 2
1944 3
1945 6
1946 55
1947 54
1948 34
1949 23
1950 20
1951 39
1952 41
1953 55
1954 46
1955 71
1956 48
1957 67
1958 63
1959 52
1960 73
1961 73
1962 85
1963 123
1964 133
1965 175
1966 216
1967 220
1968 238
1969 256
1970 249
1971 267
1972 357
1973 553
1974 520
1975 899
1976 885
1977 829
1978 848
1979 861
1980 938
1981 1088
1982 1073
1983 1250
1984 1336
1985 1446
1986 1461
1987 1495
1988 1589
1989 1776
1990 1861
1991 1857
1992 1938
1993 1883
1994 2045
1995 2041
1996 2191
1997 2073
1998 2145
1999 2259
2000 2640
2001 2628
2002 2755
2003 2888
2004 3194
2005 3367
2006 3695
2007 3906
2008 4128
2009 4222
2010 4631
2011 4997
2012 5153
2013 5470
2014 5472
2015 5711
2016 5756
2017 5680
2018 5773
2019 5914
2020 6075
2021 6219
2022 5805
2023 5540
2024 2809

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143,814 results

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The following term was not found in PubMed: tetrapeptide-18
Page 1
ACSS2-dependent histone acetylation improves cognition in mouse model of Alzheimer's disease.
Lin Y, Lin A, Cai L, Huang W, Yan S, Wei Y, Ruan X, Fang W, Dai X, Cheng J, Zhang J, Chen W, Ye Q, Chen X, Zhang J. Lin Y, et al. Mol Neurodegener. 2023 Jul 12;18(1):47. doi: 10.1186/s13024-023-00625-4. Mol Neurodegener. 2023. PMID: 37438762 Free PMC article.
BACKGROUND: Nuclear acetyl-CoA pools govern histone acetylation that controls synaptic plasticity and contributes to cognitive deterioration in patients with Alzheimer's disease (AD). Nuclear acetyl-CoA pools are generated partially from local acetate that is …
BACKGROUND: Nuclear acetyl-CoA pools govern histone acetylation that controls synaptic plasticity and contributes to cognitive …
Acetylation Targeting Chimera Enables Acetylation of the Tumor Suppressor p53.
Kabir M, Sun N, Hu X, Martin TC, Yi J, Zhong Y, Xiong Y, Kaniskan HÜ, Gu W, Parsons R, Jin J. Kabir M, et al. J Am Chem Soc. 2023 Jul 12;145(27):14932-14944. doi: 10.1021/jacs.3c04640. Epub 2023 Jun 26. J Am Chem Soc. 2023. PMID: 37365684
However, pharmacologic activation of tumor-suppressor proteins for cancer treatment remains a major challenge. Here, we present a novel Acetylation Targeting Chimera (AceTAC) strategy to acetylate the p53 tumor suppressor protein. We discovered and characterized the …
However, pharmacologic activation of tumor-suppressor proteins for cancer treatment remains a major challenge. Here, we present a novel A
Sirtuin-1 sensitive lysine-136 acetylation drives phase separation and pathological aggregation of TDP-43.
Garcia Morato J, Hans F, von Zweydorf F, Feederle R, Elsässer SJ, Skodras AA, Gloeckner CJ, Buratti E, Neumann M, Kahle PJ. Garcia Morato J, et al. Nat Commun. 2022 Mar 9;13(1):1223. doi: 10.1038/s41467-022-28822-7. Nat Commun. 2022. PMID: 35264561 Free PMC article.
Investigating TDP-43 post-translational modifications, we discovered that K84 acetylation reduced nuclear import whereas K136 acetylation impaired RNA binding and splicing capabilities of TDP-43. ...K84-acetylated TDP-43 showed cytoplasmic mislocalization, an …
Investigating TDP-43 post-translational modifications, we discovered that K84 acetylation reduced nuclear import whereas K136 acet
Current trends in protein acetylation analysis.
Diallo I, Seve M, Cunin V, Minassian F, Poisson JF, Michelland S, Bourgoin-Voillard S. Diallo I, et al. Expert Rev Proteomics. 2019 Feb;16(2):139-159. doi: 10.1080/14789450.2019.1559061. Epub 2018 Dec 24. Expert Rev Proteomics. 2019. PMID: 30580641 Review.
Over the last decade, acetylation analyses required the development of multiple methods to target individual acetylated proteins, as well as to cover a broader description of acetylated proteins that comprise the acetylome. Areas covered: This review discusse …
Over the last decade, acetylation analyses required the development of multiple methods to target individual acetylated protei …
9-O Acetylated Gangliosides in Health and Disease.
Herrera-Marcos LV, Sahali D, Ollero M. Herrera-Marcos LV, et al. Biomolecules. 2023 May 12;13(5):827. doi: 10.3390/biom13050827. Biomolecules. 2023. PMID: 37238697 Free PMC article. Review.
Within this vast family of molecules, gangliosides modified by acetylation represent a minority. Described for the first time in the 1980s, their relation to pathologies has resulted in increased interest in their function in normal and diseased cells. This review presents …
Within this vast family of molecules, gangliosides modified by acetylation represent a minority. Described for the first time in the …
Gel characteristics of low-acetyl spruce galactoglucomannans.
Karppanen H, Halahlah A, Kilpeläinen PO, Mikkonen KS, Ho TM. Karppanen H, et al. Carbohydr Polym. 2023 Dec 1;321:121316. doi: 10.1016/j.carbpol.2023.121316. Epub 2023 Aug 19. Carbohydr Polym. 2023. PMID: 37739540 Free article.
Here we present the characterization of hydrogels prepared from GGM after tailoring the degree of acetylation by alkaline treatment during its recovery. Specifically, we investigated gel characteristics of low-acetyl GGM dispersions prepared at varied solid concentr …
Here we present the characterization of hydrogels prepared from GGM after tailoring the degree of acetylation by alkaline treatment d …
Metabolic and Cellular Compartments of Acetyl-CoA in the Healthy and Diseased Brain.
Jankowska-Kulawy A, Klimaszewska-Łata J, Gul-Hinc S, Ronowska A, Szutowicz A. Jankowska-Kulawy A, et al. Int J Mol Sci. 2022 Sep 3;23(17):10073. doi: 10.3390/ijms231710073. Int J Mol Sci. 2022. PMID: 36077475 Free PMC article. Review.
Thus, acetyl-CoA is regarded as a direct energy precursor through the TCA cycle and respiratory chain, thereby affecting brain cell viability. It is also used for hundreds of acetylation reactions, including N-acetyl aspartate synthesis in neuronal mitochondr …
Thus, acetyl-CoA is regarded as a direct energy precursor through the TCA cycle and respiratory chain, thereby affecting brain cell v …
Epigenetic therapy for colorectal cancer.
Vaish V, Khare T, Verma M, Khare S. Vaish V, et al. Methods Mol Biol. 2015;1238:771-82. doi: 10.1007/978-1-4939-1804-1_40. Methods Mol Biol. 2015. PMID: 25421691 Review.
Aberrations in epigenome that include alterations in DNA methylation, histone acetylation, and miRNA (microRNA) expression may govern the progression of colorectal cancer (CRC). ...Since epigenetic alterations can be reversed by DNA demethylating and histone acetylating
Aberrations in epigenome that include alterations in DNA methylation, histone acetylation, and miRNA (microRNA) expression may govern …
Bacterial protein acetylation: new discoveries unanswered questions.
Wolfe AJ. Wolfe AJ. Curr Genet. 2016 May;62(2):335-41. doi: 10.1007/s00294-015-0552-4. Epub 2015 Dec 12. Curr Genet. 2016. PMID: 26660885 Free PMC article. Review.
Nepsilon-acetylation is emerging as an abundant post-translational modification of bacterial proteins. Two mechanisms have been identified: one is enzymatic, dependent on an acetyltransferase and acetyl-coenzyme A; the other is non-enzymatic and depends on the react …
Nepsilon-acetylation is emerging as an abundant post-translational modification of bacterial proteins. Two mechanisms have been ident …
Lysine acetylation and cancer: A proteomics perspective.
Gil J, Ramírez-Torres A, Encarnación-Guevara S. Gil J, et al. J Proteomics. 2017 Jan 6;150:297-309. doi: 10.1016/j.jprot.2016.10.003. Epub 2016 Oct 13. J Proteomics. 2017. PMID: 27746255 Review.
Acetylated lysine residues are recognized by bromodomains, a family of evolutionarily conserved domains. The use of high-resolution mass spectrometry-based proteomics, in combination with the enrichment of acetylated peptides through immunoprecipitation with anti-
Acetylated lysine residues are recognized by bromodomains, a family of evolutionarily conserved domains. The use of high-resolution m
143,814 results
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