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Year Number of Results
1983 1
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1999 1
2000 3
2001 1
2003 3
2004 3
2005 4
2006 5
2007 10
2008 5
2009 6
2010 7
2011 8
2012 4
2013 11
2014 10
2015 9
2016 8
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2018 8
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2021 11
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Page 1
Intravenous N-Acetylcysteine to Prevent Cisplatin-Induced Hearing Loss in Children: A Nonrandomized Controlled Phase I Trial.
Orgel E, Knight KR, Chi YY, Malvar J, Rushing T, Mena V, Eisenberg LS, Rassekh SR, Ross CJD, Scott EN, Neely M, Neuwelt EA, Muldoon LL, Freyer DR. Orgel E, et al. Clin Cancer Res. 2023 Jul 5;29(13):2410-2418. doi: 10.1158/1078-0432.CCR-23-0252. Clin Cancer Res. 2023. PMID: 37134194 Free PMC article. Clinical Trial.
PURPOSE: Cisplatin-induced hearing loss (CIHL) is common and permanent. As compared with earlier otoprotectants, we hypothesized N-acetylcysteine (NAC) offers potential for stronger otoprotection through stimulation of glutathione (GSH) production. ...Compared with …
PURPOSE: Cisplatin-induced hearing loss (CIHL) is common and permanent. As compared with earlier otoprotectants, we hypothesized N- …
Does N-acetylcysteine Improve Established Hearing Loss in Guinea Pigs?
Gill G, Blakley BW. Gill G, et al. OTO Open. 2022 May 17;6(2):2473974X221100545. doi: 10.1177/2473974X221100545. eCollection 2022 Apr-Jun. OTO Open. 2022. PMID: 35602237 Free PMC article.
OBJECTIVE: To assess whether multiple injections of a powerful antioxidant can improve established sensorineural hearing loss in guinea pigs. STUDY DESIGN: Animal study. SETTING: Animal science laboratory, University of Manitoba. METHODS: A total of 16 guinea pigs were use …
OBJECTIVE: To assess whether multiple injections of a powerful antioxidant can improve established sensorineural hearing loss in guin …
PRDX1 activates autophagy via the PTEN-AKT signaling pathway to protect against cisplatin-induced spiral ganglion neuron damage.
Liu W, Xu L, Wang X, Zhang D, Sun G, Wang M, Wang M, Han Y, Chai R, Wang H. Liu W, et al. Autophagy. 2021 Dec;17(12):4159-4181. doi: 10.1080/15548627.2021.1905466. Epub 2021 Apr 12. Autophagy. 2021. PMID: 33749526 Free PMC article.
The ototoxic drug cisplatin can damage SGNs and thus lead to sensorineural hearing loss (SNHL), and there are currently no methods for preventing or treating this. ...These findings suggest potential therapeutic targets for the amelioration of drug-induced SNHL through aut …
The ototoxic drug cisplatin can damage SGNs and thus lead to sensorineural hearing loss (SNHL), and there are currently no methods fo …
Effects of oral N-acetylcysteine combined with oral prednisolone on idiopathic sudden sensorineural hearing loss.
Chen SL, Ho CY, Chin SC. Chen SL, et al. Medicine (Baltimore). 2022 Jul 1;101(26):e29792. doi: 10.1097/MD.0000000000029792. Medicine (Baltimore). 2022. PMID: 35777063 Free PMC article.
BACKGROUND: Idiopathic sudden sensorineural hearing loss (ISSNHL) is an acute condition that presents with sudden hearing loss, for which steroids remain the main treatment. N-acetylcysteine (NAC), as a precursor of glutathione, can reduce the production of r …
BACKGROUND: Idiopathic sudden sensorineural hearing loss (ISSNHL) is an acute condition that presents with sudden hearing loss …
N-Acetylcysteine Combined With Dexamethasone Treatment Improves Sudden Sensorineural Hearing Loss and Attenuates Hair Cell Death Caused by ROS Stress.
Bai X, Chen S, Xu K, Jin Y, Niu X, Xie L, Qiu Y, Liu XZ, Sun Y. Bai X, et al. Front Cell Dev Biol. 2021 Mar 18;9:659486. doi: 10.3389/fcell.2021.659486. eCollection 2021. Front Cell Dev Biol. 2021. PMID: 33816510 Free PMC article.
Sudden sensorineural hearing loss (SSNHL) is a common emergency in the world. Increasing evidence of imbalance of oxidant-antioxidant were found in SSNHL patients. ...Overall, there was no statistical difference in final pure-tone threshold average (PTA) improvement betwee …
Sudden sensorineural hearing loss (SSNHL) is a common emergency in the world. Increasing evidence of imbalance of oxidant-antioxidant …
Natural Multifunctional Silk Microcarriers for Noise-Induced Hearing Loss Therapy.
Zhang H, Chen H, Lu L, Wang H, Zhao Y, Chai R. Zhang H, et al. Adv Sci (Weinh). 2024 Jan;11(1):e2305215. doi: 10.1002/advs.202305215. Epub 2023 Nov 20. Adv Sci (Weinh). 2024. PMID: 37984871 Free PMC article.
Noise-induced hearing loss (NIHL) is a common outcome of excessive reactive oxygen species in the cochlea, and the targeted delivery of antioxidants to the inner ear is a potential therapeutic strategy. ...Based on these features, it is demonstrated here that n-acetylcy …
Noise-induced hearing loss (NIHL) is a common outcome of excessive reactive oxygen species in the cochlea, and the targeted delivery …
Effect of N-acetyl-cysteine treatment on sensorineural hearing loss: a meta-analysis.
Bai X, Wang M, Niu X, Yu H, Yue JX, Sun Y. Bai X, et al. World J Otorhinolaryngol Head Neck Surg. 2022 May 12;8(3):205-212. doi: 10.1016/j.wjorl.2021.01.005. eCollection 2022 Sep. World J Otorhinolaryngol Head Neck Surg. 2022. PMID: 36159904 Free PMC article. Review.
In this study, we investigated the effect of NAC treatment on sensorineural hearing loss. PubMed, Web of Science and Embase databases were searched in their entirety using the key words: hearing loss, NAC, N-acetylcysteine, and sensorineural hearing lo …
In this study, we investigated the effect of NAC treatment on sensorineural hearing loss. PubMed, Web of Science and Embase databases …
N-acetylcysteine: multiple clinical applications.
Millea PJ. Millea PJ. Am Fam Physician. 2009 Aug 1;80(3):265-9. Am Fam Physician. 2009. PMID: 19621836 Free article. Review.
N-acetylcysteine is the acetylated variant of the amino acid L-cysteine and is widely used as the specific antidote for acetaminophen overdose. ...Preliminary studies suggest that N-acetylcysteine may also have a role as a cancer chemopreventive, an adjunct in the e …
N-acetylcysteine is the acetylated variant of the amino acid L-cysteine and is widely used as the specific antidote for acetaminophen …
ABCC1 deficiency potentiated noise-induced hearing loss in mice by impairing cochlear antioxidant capacity.
Liu J, Bai Y, Feng Y, Liu X, Pang B, Zhang S, Jiang M, Chen A, Huang H, Chen Y, Ling J, Mei L. Liu J, et al. Redox Biol. 2024 Aug;74:103218. doi: 10.1016/j.redox.2024.103218. Epub 2024 Jun 1. Redox Biol. 2024. PMID: 38870779 Free PMC article.
Mutations in ABCC1 can result in autosomal dominant hearing loss. However, the specific roles of ABCC1 in auditory function are not fully understood. ...The exogenous antioxidant N-acetylcysteine (NAC) may protect against oxidative damage in Abcc1(-/-) murine cochle …
Mutations in ABCC1 can result in autosomal dominant hearing loss. However, the specific roles of ABCC1 in auditory function are not f …
150 results

Searches related to "acetylcysteine hearing"