Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My Custom Filters

Edit custom filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1971 1
1976 1
1982 2
1983 3
1984 2
1985 5
1986 1
1987 1
1988 4
1989 8
1990 6
1991 7
1992 7
1993 3
1994 12
1995 13
1996 13
1997 13
1998 12
1999 13
2000 16
2001 9
2002 24
2003 28
2004 36
2005 34
2006 37
2007 41
2008 48
2009 47
2010 48
2011 50
2012 56
2013 71
2014 63
2015 53
2016 67
2017 53
2018 53
2019 50
2020 56
2021 51
2022 48
2023 51
2024 39
2025 49
2026 27

Publication date

Text availability

Article attribute

Article type

Additional filters

Article Language

Species

Sex

Age

Other

Search Results

1,179 results

Results by year

Filters applied: Meta-Analysis, Randomized Controlled Trial. Clear all
Page 1
Glucocorticoids plus N-acetylcysteine in severe alcoholic hepatitis.
Nguyen-Khac E, Thevenot T, Piquet MA, Benferhat S, Goria O, Chatelain D, Tramier B, Dewaele F, Ghrib S, Rudler M, Carbonell N, Tossou H, Bental A, Bernard-Chabert B, Dupas JL; AAH-NAC Study Group. Nguyen-Khac E, et al. N Engl J Med. 2011 Nov 10;365(19):1781-9. doi: 10.1056/NEJMoa1101214. N Engl J Med. 2011. PMID: 22070475 Free article. Clinical Trial.
We investigated whether combination therapy with glucocorticoids plus N-acetylcysteine would improve survival. METHODS: We randomly assigned 174 patients to receive prednisolone plus N-acetylcysteine (85 patients) or only prednisolone (89 patients). ...Secondary out …
We investigated whether combination therapy with glucocorticoids plus N-acetylcysteine would improve survival. METHODS: We randomly a …
Effectiveness of N-acetylcysteine in autism spectrum disorders: A meta-analysis of randomized controlled trials.
Lee TM, Lee KM, Lee CY, Lee HC, Tam KW, Loh EW. Lee TM, et al. Aust N Z J Psychiatry. 2021 Feb;55(2):196-206. doi: 10.1177/0004867420952540. Epub 2020 Sep 8. Aust N Z J Psychiatry. 2021. PMID: 32900213
Here, we analyzed the treatment effects of N-acetylcysteine on autism spectrum disorder in randomized controlled trials. STUDY DESIGN: Updated systematic review and meta-analysis. ...DATA SYNTHESIS: After 8-12 weeks of N-acetylcysteine supplementation, the pooled re …
Here, we analyzed the treatment effects of N-acetylcysteine on autism spectrum disorder in randomized controlled trials. STUDY DESIGN …
Influence of N-acetylcysteine on chronic bronchitis or COPD exacerbations: a meta-analysis.
Cazzola M, Calzetta L, Page C, Jardim J, Chuchalin AG, Rogliani P, Matera MG. Cazzola M, et al. Eur Respir Rev. 2015 Sep;24(137):451-61. doi: 10.1183/16000617.00002215. Eur Respir Rev. 2015. PMID: 26324807 Free PMC article. Review.
In order to clarify the possible role of N-acetylcysteine (NAC) in the treatment of patients with chronic bronchitis and chronic obstructive pulmonary disease (COPD), we have carried out a meta-analysis testing the available evidence that NAC treatment may be effective in …
In order to clarify the possible role of N-acetylcysteine (NAC) in the treatment of patients with chronic bronchitis and chronic obst …
A non-inferiority randomised controlled trial of a shorter acetylcysteine regimen for paracetamol overdose - the SARPO trial.
Isbister G, Chiew A, Buckley N, Harris K, Berling I, Downes M, Page C, Isoardi K. Isbister G, et al. J Hepatol. 2025 Oct;83(4):881-887. doi: 10.1016/j.jhep.2025.05.008. Epub 2025 May 23. J Hepatol. 2025. PMID: 40414507 Free article. Clinical Trial.
BACKGROUND & AIMS: Paracetamol is a commonly overdosed medication worldwide. Early acetylcysteine treatment can prevent hepatotoxicity. Multiple intravenous acetylcysteine regimens exist; the commonest recommending 300 mg/kg over 20 h. ...METHODS: In a multicent …
BACKGROUND & AIMS: Paracetamol is a commonly overdosed medication worldwide. Early acetylcysteine treatment can prevent hepatotox …
Efficacy of N-Acetylcysteine in Polycystic Ovary Syndrome: Systematic Review and Meta-Analysis.
Viña I, Viña JR, Carranza M, Mariscal G. Viña I, et al. Nutrients. 2025 Jan 14;17(2):284. doi: 10.3390/nu17020284. Nutrients. 2025. PMID: 39861414 Free PMC article.
BACKGROUND: Polycystic ovary syndrome (PCOS) is a common endocrine disorder that affects women of reproductive age and requires better treatment. N-acetylcysteine (NAC) is known to be beneficial under such conditions owing to its antioxidant potential and insulin-sensitizi …
BACKGROUND: Polycystic ovary syndrome (PCOS) is a common endocrine disorder that affects women of reproductive age and requires better treat …
N-acetylcysteine for non-paracetamol (acetaminophen)-related acute liver failure.
Siu JT, Nguyen T, Turgeon RD. Siu JT, et al. Cochrane Database Syst Rev. 2020 Dec 9;12(12):CD012123. doi: 10.1002/14651858.CD012123.pub2. Cochrane Database Syst Rev. 2020. PMID: 33294991 Free PMC article.
OBJECTIVES: To assess the benefits and harms of N-acetylcysteine compared with placebo or no N-acetylcysteine, as an adjunct to usual care, in people with non-paracetamol-related acute liver failure. ...For all-cause mortality at 21 days between adults receiving N- …
OBJECTIVES: To assess the benefits and harms of N-acetylcysteine compared with placebo or no N-acetylcysteine, as an adjunct t …
N-acetylcysteine as a treatment for substance use cravings: A meta-analysis.
Winterlind EL, Malone SG, Setzer MR, Murphy MA, Saunders D, Gray JC. Winterlind EL, et al. Addict Biol. 2024 Nov;29(11):e70001. doi: 10.1111/adb.70001. Addict Biol. 2024. PMID: 39556483 Free PMC article.
N-acetylcysteine (NAC) may serve as a novel pharmacotherapy for substance use and substance craving in individuals with substance use disorders (SUDs), possibly through its potential to regulate glutamate. ...
N-acetylcysteine (NAC) may serve as a novel pharmacotherapy for substance use and substance craving in individuals with substance use …
Efficacy of N-acetylcysteine for patients with depression: An updated systematic review and meta-analysis.
Peng TR, Lin HH, Tseng TL, Huang YH, Tsai PY, Lin CY, Lee MC, Chen SM. Peng TR, et al. Gen Hosp Psychiatry. 2024 Nov-Dec;91:151-159. doi: 10.1016/j.genhosppsych.2024.10.018. Epub 2024 Nov 3. Gen Hosp Psychiatry. 2024. PMID: 39504621
BACKGROUND: Results on whether N-acetylcysteine (NAC) ameliorates depression in patients with psychiatric problems, such as bipolar disorder and major depressive disorder, remain inconsistent, and several new studies have recently been published. ...
BACKGROUND: Results on whether N-acetylcysteine (NAC) ameliorates depression in patients with psychiatric problems, such as bipolar d …
Comparison of two-bag and three-bag acetylcysteine regimens in the treatment of paracetamol poisoning: a systematic review and meta-analysis.
Nakatsu L, Lopez JR, Garcia CM, Cherian M, Nash J, Tofighi D, Seifert SA, Smolinske S, Warrick BJ. Nakatsu L, et al. Clin Toxicol (Phila). 2025 Mar;63(3):155-165. doi: 10.1080/15563650.2025.2456116. Epub 2025 Feb 27. Clin Toxicol (Phila). 2025. PMID: 40013897
The Medical Subject Headings terms were NAC, acetaminophen toxicity, acetyl-cysteine, N-acetylcysteine, paracetamol, APAP, 2-bag, and 3-bag. The Embase terms were acetylcysteine, NAC, 2-bag, two bag, 3-bag, three bag, simplified dosing, acetaminophen, Tylenol( ), pa …
The Medical Subject Headings terms were NAC, acetaminophen toxicity, acetyl-cysteine, N-acetylcysteine, paracetamol, APAP, 2-bag, and …
1,179 results