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Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1980 3
1981 8
1982 23
1983 33
1984 17
1985 23
1986 21
1987 18
1988 24
1989 19
1990 12
1991 25
1992 22
1993 27
1994 34
1995 45
1996 33
1997 37
1998 41
1999 24
2000 25
2001 25
2002 37
2003 28
2004 26
2005 23
2006 20
2007 24
2008 37
2009 41
2010 35
2011 33
2012 39
2013 25
2014 16
2015 29
2016 24
2017 22
2018 20
2019 19
2020 14
2021 22
2022 15
2023 15
2024 22
2025 22
2026 14

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1,102 results

Results by year

Filters applied: Meta-Analysis, Randomized Controlled Trial. Clear all
Page 1
Herpetic Eye Disease Study. A controlled trial of oral acyclovir for herpes simplex stromal keratitis.
Barron BA, Gee L, Hauck WW, Kurinij N, Dawson CR, Jones DB, Wilhelmus KR, Kaufman HE, Sugar J, Hyndiuk RA, et al. Barron BA, et al. Ophthalmology. 1994 Dec;101(12):1871-82. doi: 10.1016/s0161-6420(13)31155-5. Ophthalmology. 1994. PMID: 7997323 Clinical Trial.
By 16 weeks, 38 patients (75%) in the acyclovir group and 39 patients (74%) in the placebo group had failed treatment. Also by that time, the keratitis had resolved with trial medications, and there was no subsequent worsening in nine patients (18%) in the acyclovir …
By 16 weeks, 38 patients (75%) in the acyclovir group and 39 patients (74%) in the placebo group had failed treatment. Also by that t …
Safety and efficacy of adjunct dexamethasone in adults with herpes simplex virus encephalitis in the UK (DexEnceph): a multicentre, observer-blind, randomised, phase 3, controlled trial.
Solomon T, Hooper C, Easton A, Rosala-Hallas A, Facer B, Moore P, Keller SS, Whitfield T, Fernandez C, Kneen R, Griffiths MJ, Das K, Moore SC, Davies K, Wheatley D, Stahl JP, Hardwick B, Defres S, Michael BD; DexEnceph Study Group; Burnside G, Ellul MA. Solomon T, et al. Lancet Neurol. 2026 Feb;25(2):136-146. doi: 10.1016/S1474-4422(25)00454-5. Lancet Neurol. 2026. PMID: 41579900 Free article. Clinical Trial.
METHODS: In this multicentre, observer-blind, randomised, phase 3 trial, adults with HSV encephalitis admitted to 53 hospitals in the UK were randomly assigned to receive intravenous dexamethasone (10 mg/kg, four times daily for 4 days) plus intravenous aciclovir (10 mg/kg …
METHODS: In this multicentre, observer-blind, randomised, phase 3 trial, adults with HSV encephalitis admitted to 53 hospitals in the UK wer …
Kanuka honey versus aciclovir for the topical treatment of herpes simplex labialis: a randomised controlled trial.
Semprini A, Singer J, Braithwaite I, Shortt N, Thayabaran D, McConnell M, Weatherall M, Beasley R. Semprini A, et al. BMJ Open. 2019 May 14;9(5):e026201. doi: 10.1136/bmjopen-2018-026201. BMJ Open. 2019. PMID: 31092654 Free PMC article. Clinical Trial.
OBJECTIVE: To compare New Zealand medical grade kanuka honey with topical aciclovir for the treatment of herpes simplex labialis. DESIGN: Prospective parallel randomised controlled open-label superiority trial. ...INTERVENTIONS: Random assignment 1:1 to either 5% aciclo …
OBJECTIVE: To compare New Zealand medical grade kanuka honey with topical aciclovir for the treatment of herpes simplex labialis. DES …
Acyclovir in shingles.
Bean B, Aeppli D, Balfour HH Jr. Bean B, et al. J Antimicrob Chemother. 1983 Sep;12 Suppl B:123-7. doi: 10.1093/jac/12.suppl_b.123. J Antimicrob Chemother. 1983. PMID: 6355047 Review.
Acyclovir given intravenously in either low dose (5 mg/kg every 8 h) or high dose (500 mg/m2 every 8 h) significantly reduced pain and accelerated skin healing in acute herpes zoster occurring in otherwise healthy adults. ...No adverse effects were associated with the lowe …
Acyclovir given intravenously in either low dose (5 mg/kg every 8 h) or high dose (500 mg/m2 every 8 h) significantly reduced pain an …
Comparable aciclovir exposures produced by oral valaciclovir and intravenous aciclovir in immunocompromised cancer patients.
Höglund M, Ljungman P, Weller S. Höglund M, et al. J Antimicrob Chemother. 2001 Jun;47(6):855-61. doi: 10.1093/jac/47.6.855. J Antimicrob Chemother. 2001. PMID: 11389118 Clinical Trial.
The objective of this study was to evaluate the comparability of systemic aciclovir exposure at steady state in immunocompromised patients following oral valaciclovir 1000 mg tds and intravenous (iv) aciclovir 5 mg/kg tds. ...The mean absolute bioavailability of …
The objective of this study was to evaluate the comparability of systemic aciclovir exposure at steady state in immunocompromised pat …
Acyclovir efficacy for bell's palsy treatment.
Günebakan Ç, Kuzu S, Bozkurt E. Günebakan Ç, et al. Am J Otolaryngol. 2025 Sep-Oct;46(5):104637. doi: 10.1016/j.amjoto.2025.104637. Epub 2025 Apr 28. Am J Otolaryngol. 2025. PMID: 40580762 Free article. Clinical Trial.
PURPOSE: This study aims to analyze the results regarding prednisolone alone, and the combined use of acyclovir with prednisolone in the treatment modality of Bell's palsy. METHODS: In this prospective, randomized clinical study, which was held in a single tertiary hospita …
PURPOSE: This study aims to analyze the results regarding prednisolone alone, and the combined use of acyclovir with prednisolone in …
Lack of bioequivalence between two aciclovir tablets in healthy subjects.
Amini H, Javan M, Gazerani P, Ghaffari A, Ahmadiani A. Amini H, et al. Clin Drug Investig. 2008;28(1):47-53. doi: 10.2165/00044011-200828010-00006. Clin Drug Investig. 2008. PMID: 18081360 Clinical Trial.
OBJECTIVE: This study aimed to compare the systemic bioavailability of two aciclovir tablets, Rouz-Aciclovir (test) and Zovirax (reference), in 12 healthy volunteers. METHODS: In a crossover design, each subject received a single oral dose of aciclovir 400 mg …
OBJECTIVE: This study aimed to compare the systemic bioavailability of two aciclovir tablets, Rouz-Aciclovir (test) and Zovira …
Effect of aciclovir on HIV-1 acquisition in herpes simplex virus 2 seropositive women and men who have sex with men: a randomised, double-blind, placebo-controlled trial.
Celum C, Wald A, Hughes J, Sanchez J, Reid S, Delany-Moretlwe S, Cowan F, Casapia M, Ortiz A, Fuchs J, Buchbinder S, Koblin B, Zwerski S, Rose S, Wang J, Corey L; HPTN 039 Protocol Team. Celum C, et al. Lancet. 2008 Jun 21;371(9630):2109-19. doi: 10.1016/S0140-6736(08)60920-4. Lancet. 2008. PMID: 18572080 Free PMC article. Clinical Trial.
Incidence of genital ulcers on examination was reduced by 47% (relative risk 0.53 [0.46-0.62]) and HSV-2 positive genital ulcers by 63% (0.37 [0.31-0.45]) in the aciclovir group. Adherence to dispensed study drug was 94% in the aciclovir group and 94% in the placebo …
Incidence of genital ulcers on examination was reduced by 47% (relative risk 0.53 [0.46-0.62]) and HSV-2 positive genital ulcers by 63% (0.3 …
[Zovirax].
[No authors listed] [No authors listed] Klin Wochenschr. 1983 Aug 15;61(16):829-30. Klin Wochenschr. 1983. PMID: 6355640 Clinical Trial. German. No abstract available.
PEPtalk2: results of a pilot randomised controlled trial to compare VZIG and aciclovir as postexposure prophylaxis (PEP) against chickenpox in children with cancer.
Bate J, Baker S, Breuer J, Chisholm JC, Gray J, Hambleton S, Houlton A, Jit M, Lowis S, Makin G, O'Sullivan C, Patel SR, Phillips R, Ransinghe N, Ramsay ME, Skinner R, Wheatley K, Heath PT. Bate J, et al. Arch Dis Child. 2019 Jan;104(1):25-29. doi: 10.1136/archdischild-2017-314212. Epub 2018 May 5. Arch Dis Child. 2019. PMID: 29730641 Clinical Trial.
OBJECTIVE: To determine the likely rate of patient randomisation and to facilitate sample size calculation for a full-scale phase III trial of varicella zoster immunoglobulin (VZIG) and aciclovir as postexposure prophylaxis against chickenpox in children with cancer. DESIG …
OBJECTIVE: To determine the likely rate of patient randomisation and to facilitate sample size calculation for a full-scale phase III trial …
1,102 results