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1982 70
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1987 117
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2012 842
2013 844
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20,091 results

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Page 1
Gestalt-binding of tropomyosin on actin during thin filament activation.
Lehman W, Orzechowski M, Li XE, Fischer S, Raunser S. Lehman W, et al. J Muscle Res Cell Motil. 2013 Aug;34(3-4):155-63. doi: 10.1007/s10974-013-9342-0. Epub 2013 May 12. J Muscle Res Cell Motil. 2013. PMID: 23666668 Free PMC article. Review.
Taking the Gestalt-binding of tropomyosin into account, coupled with our electron microscopy structures and computational chemistry, we propose a comprehensive mechanism for tropomyosin regulatory movement over the actin filament surface that explains the coo …
Taking the Gestalt-binding of tropomyosin into account, coupled with our electron microscopy structures and computational chemistry, …
Biochemical and mechanical regulation of actin dynamics.
Lappalainen P, Kotila T, Jégou A, Romet-Lemonne G. Lappalainen P, et al. Nat Rev Mol Cell Biol. 2022 Dec;23(12):836-852. doi: 10.1038/s41580-022-00508-4. Epub 2022 Aug 2. Nat Rev Mol Cell Biol. 2022. PMID: 35918536 Review.
Consequently, aberrant actin cytoskeleton dynamics are linked to various diseases, including cancer, as well as immunological and neurological disorders. ...Indeed, the architecture and dynamics of the actin cytoskeleton are directly tuned by mechanica …
Consequently, aberrant actin cytoskeleton dynamics are linked to various diseases, including cancer, as well as immunological …
Structural basis of actin filament assembly and aging.
Oosterheert W, Klink BU, Belyy A, Pospich S, Raunser S. Oosterheert W, et al. Nature. 2022 Nov;611(7935):374-379. doi: 10.1038/s41586-022-05241-8. Epub 2022 Oct 26. Nature. 2022. PMID: 36289337 Free PMC article.
It remains unclear how F-actin hydrolyses ATP and subsequently undergoes subtle conformational rearrangements that ultimately lead to filament depolymerization by actin-binding proteins. ...Our work elucidates the solvent-driven rearrangements that gov …
It remains unclear how F-actin hydrolyses ATP and subsequently undergoes subtle conformational rearrangements that ultimately lead to …
Biased localization of actin binding proteins by actin filament conformation.
Harris AR, Jreij P, Belardi B, Joffe AM, Bausch AR, Fletcher DA. Harris AR, et al. Nat Commun. 2020 Nov 25;11(1):5973. doi: 10.1038/s41467-020-19768-9. Nat Commun. 2020. PMID: 33239610 Free PMC article.
Here, we show that the actin-binding domains of accessory proteins can be sensitive to filament conformational changes. ...We demonstrate that the binding kinetics of CH1-CH2 domain mutants varies as actin filament conformation is altered …
Here, we show that the actin-binding domains of accessory proteins can be sensitive to filament conformational changes. …
Side-binding proteins modulate actin filament dynamics.
Crevenna AH, Arciniega M, Dupont A, Mizuno N, Kowalska K, Lange OF, Wedlich-Söldner R, Lamb DC. Crevenna AH, et al. Elife. 2015 Feb 23;4:e04599. doi: 10.7554/eLife.04599. Elife. 2015. PMID: 25706231 Free PMC article.
Actin filament dynamics govern many key physiological processes from cell motility to tissue morphogenesis. ...It is currently thought that filament kinetics can be described by a single rate constant for each end. In this study, using direct visualization of …
Actin filament dynamics govern many key physiological processes from cell motility to tissue morphogenesis. ...It is currently …
Actin filament organization and myosin head labelling patterns in vertebrate skeletal muscles in the rigor and weak binding states.
Squire JM, Harford JJ. Squire JM, et al. J Muscle Res Cell Motil. 1988 Aug;9(4):344-58. doi: 10.1007/BF01773878. J Muscle Res Cell Motil. 1988. PMID: 3065359 Review.
On this basis, each actin target area comprises about four actin monomers along one of the two long-pitched helical strands of the actin filament (about 200 A) or an azimuthal range of actin binding sites of about 100 degrees around the t …
On this basis, each actin target area comprises about four actin monomers along one of the two long-pitched helical strands of …
Structural basis for cofilin binding and actin filament disassembly.
Tanaka K, Takeda S, Mitsuoka K, Oda T, Kimura-Sakiyama C, Maéda Y, Narita A. Tanaka K, et al. Nat Commun. 2018 May 10;9(1):1860. doi: 10.1038/s41467-018-04290-w. Nat Commun. 2018. PMID: 29749375 Free PMC article.
Here, we present the 3.8 A resolution cryo-EM structure of cofilactin (cofilin-decorated actin filament). The actin subunit structure of cofilactin (C-form) is distinct from those of F-actin (F-form) and monomeric actin (G-form). ...The cofilin- …
Here, we present the 3.8 A resolution cryo-EM structure of cofilactin (cofilin-decorated actin filament). The actin sub …
Actin filament association at adherens junctions.
Yonemura S. Yonemura S. J Med Invest. 2017;64(1.2):14-19. doi: 10.2152/jmi.64.14. J Med Invest. 2017. PMID: 28373611 Free article. Review.
There are three types of AJs in terms of the mode of actin filament/AJ association. Among many actin-binding proteins associated with AJs, alpha-catenin is one of the most important actin filament/AJ linkers that functions in all types of …
There are three types of AJs in terms of the mode of actin filament/AJ association. Among many actin-binding pro …
Mechanisms of actin filament severing and elongation by formins.
Palmer NJ, Barrie KR, Dominguez R. Palmer NJ, et al. Nature. 2024 Aug;632(8024):437-442. doi: 10.1038/s41586-024-07637-0. Epub 2024 Jun 6. Nature. 2024. PMID: 38843827 Free PMC article.
However, the lack of structures bound to the actin filament (F-actin) has been a major impediment to understanding formin function. Whereas formins are known for their ability to nucleate and elongate F-actin(3-7), some formins can additionally depolym …
However, the lack of structures bound to the actin filament (F-actin) has been a major impediment to understanding form …
Choreography of rapid actin filament disassembly by coronin, cofilin, and AIP1.
Oosterheert W, Boiero Sanders M, Hofnagel O, Bieling P, Raunser S. Oosterheert W, et al. Cell. 2025 Nov 26;188(24):6845-6860.e27. doi: 10.1016/j.cell.2025.09.016. Epub 2025 Oct 10. Cell. 2025. PMID: 41075793 Free article.
Rapid remodeling of actin filament (F-actin) networks is essential for the movement and morphogenesis of eukaryotic cells. ...Here, using cryo-electron microscopy (cryo-EM), we uncover the concerted molecular actions of coronin, cofilin, and AIP1 that lead to …
Rapid remodeling of actin filament (F-actin) networks is essential for the movement and morphogenesis of eukaryotic cel …
20,091 results
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