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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1969 2
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1973 6
1974 6
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1977 24
1978 21
1979 22
1980 51
1981 68
1982 83
1983 97
1984 141
1985 193
1986 281
1987 334
1988 436
1989 576
1990 749
1991 926
1992 1064
1993 1214
1994 1434
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1996 1717
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1998 2064
1999 2173
2000 2390
2001 2514
2002 2567
2003 2686
2004 2656
2005 2790
2006 2910
2007 2861
2008 3017
2009 2970
2010 3070
2011 3290
2012 3521
2013 3707
2014 3545
2015 3298
2016 3347
2017 3222
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2019 2994
2020 3010
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2024 2505
2025 2639
2026 1491

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86,582 results

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Page 1
Metabolic enzyme LDHA activates Rac1 GTPase as a noncanonical mechanism to promote cancer.
Liu J, Zhang C, Zhang T, Chang CY, Wang J, Bazile L, Zhang L, Haffty BG, Hu W, Feng Z. Liu J, et al. Nat Metab. 2022 Dec;4(12):1830-1846. doi: 10.1038/s42255-022-00708-4. Epub 2022 Dec 19. Nat Metab. 2022. PMID: 36536137 Free PMC article.
The oncogenic effect of LDHA has been attributed to its glycolytic enzyme activity. Here we report an unexpected noncanonical oncogenic mechanism of LDHA; LDHA activates small GTPase Rac1 to promote cancer independently of its glycolytic enzyme activity …
The oncogenic effect of LDHA has been attributed to its glycolytic enzyme activity. Here we report an unexpected noncanonical oncogen …
Intrinsic GTPase Activity of K-RAS Monitored by Native Mass Spectrometry.
Moghadamchargari Z, Huddleston J, Shirzadeh M, Zheng X, Clemmer DE, M Raushel F, Russell DH, Laganowsky A. Moghadamchargari Z, et al. Biochemistry. 2019 Aug 6;58(31):3396-3405. doi: 10.1021/acs.biochem.9b00532. Epub 2019 Jul 22. Biochemistry. 2019. PMID: 31306575 Free PMC article.
Mutations in RAS are associated with many different cancers and have been a therapeutic target for more than three decades. RAS cycles from an active to inactive state by both intrinsic and GTPase-activating protein (GAP)-stimulated hydrolysis. ...Our results …
Mutations in RAS are associated with many different cancers and have been a therapeutic target for more than three decades. RAS cycles from …
B-type Plexins promote the GTPase activity of Ran to affect androgen receptor nuclear translocation in prostate cancer.
Garg R, Endzhievskaya S, Williamson M. Garg R, et al. Cancer Gene Ther. 2023 Nov;30(11):1513-1523. doi: 10.1038/s41417-023-00655-6. Epub 2023 Aug 10. Cancer Gene Ther. 2023. PMID: 37563360 Free PMC article.
We show here that PlexinB1 and B2 regulate nuclear import by acting as GTPase activating proteins (GAPs) for the small RasGTPase Ran, a key regulator of nuclear trafficking. Purified PlexinB1/B2 protein catalyses the hydrolysis of RanGTP, and mutations in the GAP do …
We show here that PlexinB1 and B2 regulate nuclear import by acting as GTPase activating proteins (GAPs) for the small RasGTPa …
OsATG1 and OsATG8 exhibit autophagy-independent functions to oppositely regulate ROP GTPase-mediated plant immunity in rice.
He F, Tao H, Wang R, Liu J, Hao Z, Wang D, Shi X, Zhang F, Long J, Zhang H, Yang X, Qin M, Peng S, Zhang C, You X, Guo H, Li F, Gao C, Liu Y, Wang GL, Ning Y. He F, et al. Mol Plant. 2025 Sep 1;18(9):1472-1489. doi: 10.1016/j.molp.2025.07.006. Epub 2025 Jul 23. Mol Plant. 2025. PMID: 40708194
ROP GTPases regulate various cellular processes, including plant immunity. While ROP GTPase activation has been reported during plant immune responses, the mechanisms underlying the dynamic deactivation of ROP GTPases remain unclear. In this study, we …
ROP GTPases regulate various cellular processes, including plant immunity. While ROP GTPase activation has been reporte …
Activation of the small GTPase rap1 in human neutrophils.
M'Rabet L, Coffer P, Zwartkruis F, Franke B, Segal AW, Koenderman L, Bos JL. M'Rabet L, et al. Blood. 1998 Sep 15;92(6):2133-40. Blood. 1998. PMID: 9731072 Free article.
Using the Rap1-binding domain of RalGDS (RalGDS-RBD) as an activation-specific probe for Rap1, we have investigated the regulation of Rap1 activity in primary human neutrophils. We found that a variety of stimuli involved in neutrophil activation, including f …
Using the Rap1-binding domain of RalGDS (RalGDS-RBD) as an activation-specific probe for Rap1, we have investigated the regulation of …
RanGAP1 induces GTPase activity of nuclear Ras-related Ran.
Bischoff FR, Klebe C, Kretschmer J, Wittinghofer A, Ponstingl H. Bischoff FR, et al. Proc Natl Acad Sci U S A. 1994 Mar 29;91(7):2587-91. doi: 10.1073/pnas.91.7.2587. Proc Natl Acad Sci U S A. 1994. PMID: 8146159 Free PMC article.
Models of the signal pathway predict Ran to be active as Ran.GTP at the initiation of S phase upon activation by the nucleotide exchange factor RCC1 and to be inactivated for the onset of mitosis by hydrolysis of bound GTP. ...It was purified from HeLa …
Models of the signal pathway predict Ran to be active as Ran.GTP at the initiation of S phase upon activation by the nu …
Involvement of Ral GTPase in v-Src-induced phospholipase D activation.
Jiang H, Luo JQ, Urano T, Frankel P, Lu Z, Foster DA, Feig LA. Jiang H, et al. Nature. 1995 Nov 23;378(6555):409-12. doi: 10.1038/378409a0. Nature. 1995. PMID: 7477381
An early response to the tyrosine kinase activity of v-Src is an increase in phospholipase D (PLD) activity, which leads to the generation of biologically active lipid second messengers, including phosphatidic acid, lysophosphatidic acid and diacylglycerol. . …
An early response to the tyrosine kinase activity of v-Src is an increase in phospholipase D (PLD) activity, which leads to th …
CD6-mediated inhibition of T cell activation via modulation of Ras.
Henriques SN, Oliveira L, Santos RF, Carmo AM. Henriques SN, et al. Cell Commun Signal. 2022 Nov 21;20(1):184. doi: 10.1186/s12964-022-00998-x. Cell Commun Signal. 2022. PMID: 36414966 Free PMC article.
The Jurkat cell lines were further adapted to express a FRET-based unimolecular HRas biosensor that reported the activity of this crucial GTPase at the immunological synapse. RESULTS: We show that deletion of the cytosolic tail of CD6 enhances T-cell responses, indi …
The Jurkat cell lines were further adapted to express a FRET-based unimolecular HRas biosensor that reported the activity of this cru …
Inhibition of a low Km GTPase activity in rat striatum by calmodulin.
Treisman GJ, Muirhead N, Iwaniec L, Gnegy ME. Treisman GJ, et al. J Neurochem. 1985 Feb;44(2):518-25. doi: 10.1111/j.1471-4159.1985.tb05444.x. J Neurochem. 1985. PMID: 2981286 Free article.
Calmodulin inhibited GTP hydrolysis at concentrations of 10(-9)-10(-6) M but had no effect on the hydrolysis of 10(-5) and 10(-6) M GTP, suggesting that calmodulin inhibited a low Km GTPase activity. ...The characteristics of the effect of calmodulin o …
Calmodulin inhibited GTP hydrolysis at concentrations of 10(-9)-10(-6) M but had no effect on the hydrolysis of 10(-5) and 10(-6) M …
Activation of the small GTPase Ral in platelets.
Wolthuis RM, Franke B, van Triest M, Bauer B, Cool RH, Camonis JH, Akkerman JW, Bos JL. Wolthuis RM, et al. Mol Cell Biol. 1998 May;18(5):2486-91. doi: 10.1128/MCB.18.5.2486. Mol Cell Biol. 1998. PMID: 9566869 Free PMC article.
Our results show that Ral can be activated by extracellular stimuli. Furthermore, we show that increased levels of intracellular Ca2+ are sufficient for Ral activation in platelets. This activation mechanism correlates with the activation mechanism of …
Our results show that Ral can be activated by extracellular stimuli. Furthermore, we show that increased levels of intracellular Ca2+ …
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