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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1979 2
1984 1
1990 3
1991 1
1992 1
1995 1
1998 1
1999 1
2003 1
2008 1
2009 1
2010 1
2011 1
2013 2
2014 1
2017 2
2018 1
2021 1
2022 1
2023 1
2024 1

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25 results

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Filters applied: Meta-Analysis, Randomized Controlled Trial. Clear all
Page 1
Actovegin improves skeletal muscle mitochondrial respiration and functional aerobic capacity in a type 1 diabetic male murine model.
Kosik B, Larsen S, Bergdahl A. Kosik B, et al. Appl Physiol Nutr Metab. 2024 Feb 1;49(2):265-272. doi: 10.1139/apnm-2023-0004. Epub 2023 Nov 1. Appl Physiol Nutr Metab. 2024. PMID: 37913525 Clinical Trial.
Streptozotocin-induced T1D male C57B1/6 mice (aged 3-4 months) were randomized to an Actovegin group and a control group. Every third day, the Actovegin and control groups were injected intraperitoneally with (0.1 mL) Actovegin and (0.1 mL) physiological salt …
Streptozotocin-induced T1D male C57B1/6 mice (aged 3-4 months) were randomized to an Actovegin group and a control group. Every third …
Efficacy and safety of Actovegin in the treatment of intermittent claudication: results of an international, multicenter, placebo-controlled, randomized, phase IIIb clinical trial (APOLLO).
Suchkov IA, Mzhavanadze ND, Bogachev VY, Bokuchava M, Kuznetsov MR, Lukyanov YV, Kelimbetov R, Pang H, Araslanov SA. Suchkov IA, et al. Int Angiol. 2022 Oct;41(5):405-412. doi: 10.23736/S0392-9590.22.04895-7. Int Angiol. 2022. PMID: 36264097 Free article. Clinical Trial.
RESULTS: The increase in ICD after 12 weeks of Actovegin treatment was 29.19% (LS mean [Actovegin vs. placebo]; 95% CI: 9.35-49.02; P=0.0041). ...Actovegin has an acceptable safety and tolerability profile....
RESULTS: The increase in ICD after 12 weeks of Actovegin treatment was 29.19% (LS mean [Actovegin vs. placebo]; 95% CI: 9.35-4 …
Treatment of symptomatic polyneuropathy with actovegin in type 2 diabetic patients.
Ziegler D, Movsesyan L, Mankovsky B, Gurieva I, Abylaiuly Z, Strokov I. Ziegler D, et al. Diabetes Care. 2009 Aug;32(8):1479-84. doi: 10.2337/dc09-0545. Epub 2009 May 26. Diabetes Care. 2009. PMID: 19470838 Free PMC article. Clinical Trial.
OBJECTIVE To evaluate the efficacy and safety of actovegin in patients with diabetic polyneuropathy. RESEARCH DESIGN AND METHODS In this multicenter, randomized, double-blind trial, 567 patients with type 2 diabetes received 20 intravenous infusions of actovegin (2, …
OBJECTIVE To evaluate the efficacy and safety of actovegin in patients with diabetic polyneuropathy. RESEARCH DESIGN AND METHODS In t …
Predictors of response to treatment with actovegin for 6 months in patients with type 2 diabetes and symptomatic polyneuropathy.
Ziegler D, Edmundson S, Gurieva I, Mankovsky B, Papanas N, Strokov I. Ziegler D, et al. J Diabetes Complications. 2017 Jul;31(7):1181-1187. doi: 10.1016/j.jdiacomp.2017.03.012. Epub 2017 Mar 30. J Diabetes Complications. 2017. PMID: 28438471 Free article. Clinical Trial.
CONCLUSIONS: Actovegin treatment was associated with a clinically meaningful response in neuropathic symptoms and/or impairments in patients with symptomatic DSPN. Since only one predictor of response to actovegin treatment was identified, this drug seems an appropr …
CONCLUSIONS: Actovegin treatment was associated with a clinically meaningful response in neuropathic symptoms and/or impairments in p …
ARTEMIDA Trial (A Randomized Trial of Efficacy, 12 Months International Double-Blind Actovegin): A Randomized Controlled Trial to Assess the Efficacy of Actovegin in Poststroke Cognitive Impairment.
Guekht A, Skoog I, Edmundson S, Zakharov V, Korczyn AD. Guekht A, et al. Stroke. 2017 May;48(5):1262-1270. doi: 10.1161/STROKEAHA.116.014321. Stroke. 2017. PMID: 28432265 Free PMC article. Clinical Trial.
RESULTS: Two-hundred forty-eight patients were randomized to Actovegin and 255 patients to placebo. At month 6, the least squares mean change from baseline in Alzheimer's Disease Assessment Scale, cognitive subscale, extended version was -6.8 for Actovegin and -4.6 …
RESULTS: Two-hundred forty-eight patients were randomized to Actovegin and 255 patients to placebo. At month 6, the least squares mea …
[Therapeutic effect of Actovegin on acute oral mucositis caused by radiotherapy].
Dong ZY, Yang SR, Zhang JN, Yao YZ. Dong ZY, et al. Shanghai Kou Qiang Yi Xue. 2021 Feb;30(1):89-92. Shanghai Kou Qiang Yi Xue. 2021. PMID: 33907787 Clinical Trial. Chinese.
PURPOSE: To explore the clinical effect of Actovegin in the treatment of acute oral mucositis in patients with radiotherapy. METHODS: One hundred and thirteen patients with acute oral mucositis caused by radiotherapy for nasopharyngeal carcinoma admitted to the Department …
PURPOSE: To explore the clinical effect of Actovegin in the treatment of acute oral mucositis in patients with radiotherapy. METHODS: …
Topographic mapping of cognitive event-related potentials in a double-blind, placebo-controlled study with the hemoderivative Actovegin in age-associated memory impairment.
Semlitsch HV, Anderer P, Saletu B, Hochmayer I. Semlitsch HV, et al. Neuropsychobiology. 1990-1991;24(1):49-56. doi: 10.1159/000119042. Neuropsychobiology. 1990. PMID: 2132641 Clinical Trial.
In a double-blind placebo-controlled study, the effects of Actovegin on cognitive event-related potentials were studied in 18 age-associated memory impairment (AAMI) patients. Actovegin is a protein-free metabolically active hemoderivative improving oxygen and gluco …
In a double-blind placebo-controlled study, the effects of Actovegin on cognitive event-related potentials were studied in 18 age-ass …
[Oral actovegin therapy in cerebrovascular insufficiency. Studies on the therapeutic value of actovegin forte dragees in elderly patients with advanced cerebrovascular insufficiency].
Kopp H. Kopp H. Fortschr Med. 1979 Feb 15;97(7):307-12. Fortschr Med. 1979. PMID: 437665 Clinical Trial. German.
Even higher doses of the preparation were tolerated well. The effect of Actovegin forte drag. was dose-dependent--the best results were obtained with two dragees three times daily--and was clearly delimited from the effect of a parallel cardiac or circulatory therapy or of …
Even higher doses of the preparation were tolerated well. The effect of Actovegin forte drag. was dose-dependent--the best results we …
Confirmed clinical efficacy of Actovegin in elderly patients with organic brain syndrome.
Kanowski S, Kinzler E, Lehmann E, Schweizer A, Kuntz G. Kanowski S, et al. Pharmacopsychiatry. 1995 Jul;28(4):125-33. doi: 10.1055/s-2007-979604. Pharmacopsychiatry. 1995. PMID: 7491366 Clinical Trial.
A double-blind randomized clinical trial was performed comparing the therapeutic effects of Actovegin versus placebo in elderly patients with organic brain syndrome. In addition to the necessary basic internal medicine therapy, 40 geriatric patients received dialy intraven …
A double-blind randomized clinical trial was performed comparing the therapeutic effects of Actovegin versus placebo in elderly patie …
A prospective, randomized, multi-center trial to investigate Actovegin in prevention and treatment of acute oral mucositis caused by chemoradiotherapy for nasopharyngeal carcinoma.
Wu SX, Cui TT, Zhao C, Pan JJ, Xu BY, Tian Y, Cui NJ. Wu SX, et al. Radiother Oncol. 2010 Oct;97(1):113-8. doi: 10.1016/j.radonc.2010.08.003. Epub 2010 Sep 7. Radiother Oncol. 2010. PMID: 20826029 Clinical Trial.
PURPOSE: A multi-center prospective randomized trial was conducted to evaluate the efficacy and safety of Actovegin in the prevention and treatment of chemoradiotherapy-induced acute oral mucositis. ...There was no difference in the onset time of grade 3 mucositis among 3 …
PURPOSE: A multi-center prospective randomized trial was conducted to evaluate the efficacy and safety of Actovegin in the prevention …
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