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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1967 1
1968 1
1969 1
1971 1
1973 2
1974 4
1976 2
1978 1
1980 2
1981 1
1982 3
1983 6
1984 6
1985 6
1986 4
1987 5
1988 8
1989 6
1990 4
1991 15
1992 10
1993 11
1994 19
1995 12
1996 16
1997 21
1998 13
1999 20
2000 18
2001 18
2002 24
2003 17
2004 22
2005 18
2006 23
2007 25
2008 29
2009 36
2010 45
2011 43
2012 64
2013 80
2014 106
2015 106
2016 109
2017 97
2018 98
2019 90
2020 93
2021 113
2022 113
2023 123
2024 145
2025 168
2026 52

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563 results

Results by year

Filters applied: Randomized Controlled Trial, in the last 5 years. Clear all
Page 1
Sodium Bicarbonate for Severe Metabolic Acidemia and Acute Kidney Injury: The BICARICU-2 Randomized Clinical Trial.
Jung B, Jabaudon M, De Jong A, Bitker L, Audard J, Klouche K, Sarton B, Guitton C, Lasocki S, Rieu B, Canet E, Jeantrelle C, Roquilly A, Mayaux J, Verdonk F, Pottecher J, Ferrandiere M, Riu B, Garcon P, Assefi M, Detouche P, Forel JM, Roger C, Bourenne J, Jacquier S, Bougon D, Rolle A, Corne P, Benchabane N, Richard JC, Asehnoune K, Chanques G, Reignier J, Belafia F, Fosset M, Huguet H, Futier E, Molinari N, Jaber S; BICARICU-2 Study Group. Jung B, et al. JAMA. 2025 Dec 9;334(22):2000-2010. doi: 10.1001/jama.2025.20231. JAMA. 2025. PMID: 41159812 Free PMC article. Clinical Trial.
IMPORTANCE: The effect of sodium bicarbonate infusion on outcome in patients with severe metabolic acidemia and moderate to severe acute kidney injury is unknown. OBJECTIVE: To determine whether sodium bicarbonate infusion is associated with day 90 all-cause …
IMPORTANCE: The effect of sodium bicarbonate infusion on outcome in patients with severe metabolic acidemia and moderate to severe acute …
A Conservative Dialysis Strategy and Kidney Function Recovery in Dialysis-Requiring Acute Kidney Injury: The Liberation From Acute Dialysis (LIBERATE-D) Randomized Clinical Trial.
Liu KD, Siew ED, Tuot DS, Vijayan A, Matzumura Umemoto G, Birkelo BC, Lee BJ, Kwong YD, McCoy IE, Delucchi K, Zhuo H, Hsu CY. Liu KD, et al. JAMA. 2026 Jan 27;335(4):326-335. doi: 10.1001/jama.2025.21530. JAMA. 2026. PMID: 41201895 Free PMC article. Clinical Trial.
IMPORTANCE: For patients with dialysis-requiring acute kidney injury, persistent need for dialysis is associated with increased morbidity and mortality, high health care use, and poor quality of life. ...CONCLUSIONS AND RELEVANCE: A conservative dialysis stra …
IMPORTANCE: For patients with dialysis-requiring acute kidney injury, persistent need for dialysis is associated with i …
Extracorporeal Blood Purification and Acute Kidney Injury in Cardiac Surgery: The SIRAKI02 Randomized Clinical Trial.
Pérez-Fernández X, Ulsamer A, Cámara-Rosell M, Sbraga F, Boza-Hernández E, Moret-Ruíz E, Plata-Menchaca E, Santiago-Bautista D, Boronat-García P, Gumucio-Sanguino V, Peñafiel-Muñoz J, Camacho-Pérez M, Betbesé-Roig A, Forni L, Campos-Gómez A, Sabater-Riera J; SIRAKI02 Study Group. Pérez-Fernández X, et al. JAMA. 2024 Nov 5;332(17):1446-1454. doi: 10.1001/jama.2024.20630. JAMA. 2024. PMID: 39382234 Free PMC article. Clinical Trial.
IMPORTANCE: Cardiac surgery-associated acute kidney injury (CSA-AKI) remains a significant problem following cardiopulmonary bypass (CPB). ...In a sensitivity analysis, EBP was found to be more effective in terms of CSA-AKI reduction in patients with chronic …
IMPORTANCE: Cardiac surgery-associated acute kidney injury (CSA-AKI) remains a significant problem following cardiopulm …
Postoperative 20% Albumin Infusion and Acute Kidney Injury in High-Risk Cardiac Surgery Patients: The ALBICS AKI Randomized Clinical Trial.
Shehabi Y, Balachandran M, Al-Bassam W, Bailey M, Bellomo R, Bihari S, Brown A, Brown A, Collins D, Darlison PR, Li MA, Mandarano R, Sarode V, Pakavakis A; ALBICS AKI Study Investigators. Shehabi Y, et al. JAMA Surg. 2025 Aug 1;160(8):835-844. doi: 10.1001/jamasurg.2025.1683. JAMA Surg. 2025. PMID: 40498523 Clinical Trial.
IMPORTANCE: Acute kidney injury (AKI) after cardiac surgery is a common and serious complication. ...MAIN OUTCOMES AND MEASURES: The primary outcome was stage 1-3 AKI according to the creatinine-based Kidney Disease Improving Global Outcomes definition …
IMPORTANCE: Acute kidney injury (AKI) after cardiac surgery is a common and serious complication. ...MAIN OUTCOMES AND …
Early, Individualized Recommendations for Hospitalized Patients With Acute Kidney Injury: A Randomized Clinical Trial.
Aklilu AM, Menez S, Baker ML, Brown D, Dircksen KK, Dunkley KA, Gaviria SC, Farrokh S, Faulkner SC, Jones C, Kadhim BA, Le D, Li F, Makhijani A, Martin M, Moledina DG, Coronel-Moreno C, O'Connor KD, Shelton K, Shvets K, Srialluri N, Tan JW, Testani JM, Corona-Villalobos CP, Yamamoto Y, Parikh CR, Wilson FP; KAT-AKI Team. Aklilu AM, et al. JAMA. 2024 Dec 24;332(24):2081-2090. doi: 10.1001/jama.2024.22718. JAMA. 2024. PMID: 39454050 Free PMC article. Clinical Trial.
IMPORTANCE: Acute kidney injury (AKI) is a common complication during hospitalization and is associated with adverse outcomes. OBJECTIVE: To evaluate whether diagnostic and therapeutic recommendations sent by a kidney action team through the electronic …
IMPORTANCE: Acute kidney injury (AKI) is a common complication during hospitalization and is associated with adverse ou …
Phase-3 trial of recombinant human alkaline phosphatase for patients with sepsis-associated acute kidney injury (REVIVAL).
Pickkers P, Angus DC, Bass K, Bellomo R, van den Berg E, Bernholz J, Bestle MH, Doi K, Doig CJ, Ferrer R, Francois B, Gammelager H, Pedersen UG, Hoste E, Iversen S, Joannidis M, Kellum JA, Liu K, Meersch M, Mehta R, Millington S, Murray PT, Nichol A, Ostermann M, Pettilä V, Solling C, Winkel M, Young PJ, Zarbock A; REVIVAL investigators. Pickkers P, et al. Intensive Care Med. 2024 Jan;50(1):68-78. doi: 10.1007/s00134-023-07271-w. Epub 2024 Jan 3. Intensive Care Med. 2024. PMID: 38172296 Free PMC article. Clinical Trial.
PURPOSE: Ilofotase alfa is a human recombinant alkaline phosphatase with reno-protective effects that showed improved survival and reduced Major Adverse Kidney Events by 90 days (MAKE90) in sepsis-associated acute kidney injury (SA-AKI) patients. ...
PURPOSE: Ilofotase alfa is a human recombinant alkaline phosphatase with reno-protective effects that showed improved survival and reduced M …
Prevention of Cardiac Surgery-Associated Acute Kidney Injury by Implementing the KDIGO Guidelines in High-Risk Patients Identified by Biomarkers: The PrevAKI-Multicenter Randomized Controlled Trial.
Zarbock A, Küllmar M, Ostermann M, Lucchese G, Baig K, Cennamo A, Rajani R, McCorkell S, Arndt C, Wulf H, Irqsusi M, Monaco F, Di Prima AL, García Alvarez M, Italiano S, Miralles Bagan J, Kunst G, Nair S, L'Acqua C, Hoste E, Vandenberghe W, Honore PM, Kellum JA, Forni LG, Grieshaber P, Massoth C, Weiss R, Gerss J, Wempe C, Meersch M. Zarbock A, et al. Anesth Analg. 2021 Aug 1;133(2):292-302. doi: 10.1213/ANE.0000000000005458. Anesth Analg. 2021. PMID: 33684086 Clinical Trial.
BACKGROUND: Prospective, single-center trials have shown that the implementation of the Kidney Disease: Improving Global Outcomes (KDIGO) recommendations in high-risk patients significantly reduced the development of acute kidney injury (AKI) after sur …
BACKGROUND: Prospective, single-center trials have shown that the implementation of the Kidney Disease: Improving Global Outcomes (KD …
Lower-Dosage Acute Peritoneal Dialysis versus Acute Intermittent Hemodialysis in Acute Kidney Injury: A Randomized Controlled Trial.
Parapiboon W, Tatiyanupanwong S, Khositrangsikun K, Phulkerd T, Kaewdoungtien P, Pichitporn W, Lumlertgul N, Peerapornratana S, Chen F, Srisawat N. Parapiboon W, et al. Clin J Am Soc Nephrol. 2024 Aug 1;19(8):970-977. doi: 10.2215/CJN.0000000000000482. Epub 2024 May 29. Clin J Am Soc Nephrol. 2024. PMID: 38809614 Free PMC article. Clinical Trial.
KEY POINTS: The efficacy of acute peritoneal dialysis is still controversial. There was no significant difference in 28-day mortality between acute peritoneal dialysis and intermittent hemodialysis. ...CONCLUSIONS: In this study of patients with AKI, there was no si …
KEY POINTS: The efficacy of acute peritoneal dialysis is still controversial. There was no significant difference in 28-day mortality …
Effect of Delayed Remote Ischemic Preconditioning on Acute Kidney Injury and Outcomes in Patients Undergoing Cardiac Surgery: A Randomized Clinical Trial.
Jia P, Ji Q, Zou Z, Zeng Q, Ren T, Chen W, Yan Z, Shen D, Li Y, Peng F, Su Y, Xu J, Shen B, Luo Z, Wang C, Ding X. Jia P, et al. Circulation. 2024 Oct 22;150(17):1366-1376. doi: 10.1161/CIRCULATIONAHA.124.071408. Epub 2024 Sep 25. Circulation. 2024. PMID: 39319450 Free PMC article. Clinical Trial.
BACKGROUND: Remote ischemic preconditioning (RIPC) has 2 time windows for organ protection: acute and delayed. Previous studies have mainly focused on the organoprotective effects of acute RIPC. We aimed to determine whether delayed RIPC can reduce the occurrence of …
BACKGROUND: Remote ischemic preconditioning (RIPC) has 2 time windows for organ protection: acute and delayed. Previous studies have …
Continuous renal replacement therapy versus intermittent hemodialysis as first modality for renal replacement therapy in severe acute kidney injury: a secondary analysis of AKIKI and IDEAL-ICU studies.
Gaudry S, Grolleau F, Barbar S, Martin-Lefevre L, Pons B, Boulet É, Boyer A, Chevrel G, Montini F, Bohe J, Badie J, Rigaud JP, Vinsonneau C, Porcher R, Quenot JP, Dreyfuss D. Gaudry S, et al. Crit Care. 2022 Apr 4;26(1):93. doi: 10.1186/s13054-022-03955-9. Crit Care. 2022. PMID: 35379300 Free PMC article. Clinical Trial.
BACKGROUND: Intermittent hemodialysis (IHD) and continuous renal replacement therapy (CRRT) are the two main RRT modalities in patients with severe acute kidney injury (AKI). Meta-analyses conducted more than 10 years ago did not show survival difference betw …
BACKGROUND: Intermittent hemodialysis (IHD) and continuous renal replacement therapy (CRRT) are the two main RRT modalities in patients with …
563 results