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890 results

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Page 1
Assay of Monoacylglycerol Lipase Activity.
Jung KM, Piomelli D. Jung KM, et al. Methods Mol Biol. 2023;2576:285-297. doi: 10.1007/978-1-0716-2728-0_24. Methods Mol Biol. 2023. PMID: 36152196
Monoacylglycerol lipase (MGL/MAGL/MGLL) is a serine hydrolase involved in the biological deactivation of the endocannabinoid 2-arachidonoyl-sn-glycerol (2-AG). 2-AG is the most abundant endogenous lipid agonists for cannabinoid receptors in the brain and elsewhere i …
Monoacylglycerol lipase (MGL/MAGL/MGLL) is a serine hydrolase involved in the biological deactivation of the endocannabinoid 2 …
Assay of Monoacylglycerol Lipase Activity.
Jung KM, Piomelli D. Jung KM, et al. Methods Mol Biol. 2016;1412:157-68. doi: 10.1007/978-1-4939-3539-0_17. Methods Mol Biol. 2016. PMID: 27245902 Free article.
Monoacylglycerol lipase (MGL) is a serine hydrolase involved in the biological deactivation of the endocannabinoid 2-arachidonoyl-sn-glycerol (2-AG). 2-AG is one of the main endogenous lipid agonists for cannabinoid receptors in the brain and elsewhere in the body. …
Monoacylglycerol lipase (MGL) is a serine hydrolase involved in the biological deactivation of the endocannabinoid 2-arachidon …
Spatially Resolved Mapping of Monoacylglycerol Lipase Activity in the Brain.
van der Vliet D, Klinkenberg AXY, Platte R, Higgins K, Prokop S, Huizenga MCW, Kraaijevanger L, van Egmond N, Straub VM, Kole MHP, Pacher P, Katona I, Huitinga I, van der Stelt M. van der Vliet D, et al. ACS Chem Neurosci. 2025 Dec 17;16(24):4622-4635. doi: 10.1021/acschemneuro.5c00638. Epub 2025 Nov 28. ACS Chem Neurosci. 2025. PMID: 41313799 Free PMC article.
Monoacylglycerol lipase (MAGL), an enzyme degrading the neuroprotective endocannabinoid 2-arachidonoylglycerol, is the target of inhibitors currently in clinical trials for the treatment of several neurological disorders. ...Collectively, these findings establish se …
Monoacylglycerol lipase (MAGL), an enzyme degrading the neuroprotective endocannabinoid 2-arachidonoylglycerol, is the target …
Monoglyceride lipase: Structure and inhibitors.
Scalvini L, Piomelli D, Mor M. Scalvini L, et al. Chem Phys Lipids. 2016 May;197:13-24. doi: 10.1016/j.chemphyslip.2015.07.011. Epub 2015 Jul 26. Chem Phys Lipids. 2016. PMID: 26216043 Free PMC article. Review.
Monoglyceride lipase (MGL), the main enzyme responsible for the hydrolytic deactivation of the endocannabinoid 2-arachidonoyl-sn-glycerol (2-AG), is an intracellular serine hydrolase that plays critical roles in many physiological and pathological processes, such as pain, …
Monoglyceride lipase (MGL), the main enzyme responsible for the hydrolytic deactivation of the endocannabinoid 2-arachidonoyl-sn-glyc …
Structure-Activity Relationship Studies of Aryl Sulfoxides as Reversible Monoacylglycerol Lipase Inhibitors.
Jiang M, Huizenga MCW, Mohr F, Amedi A, Bakker R, van den Berg RJBHN, Deng H, van der Wel T, van Boeckel CAA, van der Stelt M. Jiang M, et al. J Med Chem. 2024 Jul 25;67(14):12331-12348. doi: 10.1021/acs.jmedchem.4c01037. Epub 2024 Jul 11. J Med Chem. 2024. PMID: 38988250 Free PMC article.
Monoacylglycerol lipase (MAGL) is the key enzyme for the hydrolysis of endocannabinoid 2-arachidonoylglycerol (2-AG). ...Previously, we reported LEI-515, an aryl sulfoxide, as a peripherally restricted, covalent reversible MAGL inhibitor that reduced neuropathic pai …
Monoacylglycerol lipase (MAGL) is the key enzyme for the hydrolysis of endocannabinoid 2-arachidonoylglycerol (2-AG). ...Previ …
Recent advances in neurodegenerative diseases therapeutics: The inhibition of monoacylglycerol lipase strategy.
Mendoza-Camacho DM, Espinoza-Gutiérrez HA, Viveros-Paredes JM, Flores-Soto ME, Tejeda-Martínez AR. Mendoza-Camacho DM, et al. Neuroscience. 2026 Aug 28;610:198-206. doi: 10.1016/j.neuroscience.2026.06.011. Epub 2026 Jun 13. Neuroscience. 2026. PMID: 42285406 Review.
In this context, the endocannabinoid system has emerged as a key modulator of neuroimmune communication and neuronal survival. Within this system, Monoacylglycerol Lipase (MAGL) plays a central role by regulating the levels of the endocannabinoid 2-Arachidonoylglyce …
In this context, the endocannabinoid system has emerged as a key modulator of neuroimmune communication and neuronal survival. Within this s …
Discovery of reversible monoacylglycerol lipase (MAGL) inhibitors based on ortho-hydroxyanilide scaffold.
Bononi G, Gado F, Masoni S, Scalabrini D, Vedova LD, Di Stefano M, Piazza L, Poles C, Lonzi C, Landucci E, Vagaggini C, Poggialini F, Brai A, Caligiuri I, Rizzolio F, Mohamed KA, Bertini S, De Lorenzi E, Dreassi E, Macchia M, Minutolo F, Laprairie RB, Granchi C, Tuccinardi T. Bononi G, et al. Bioorg Chem. 2025 Aug;163:108698. doi: 10.1016/j.bioorg.2025.108698. Epub 2025 Jun 19. Bioorg Chem. 2025. PMID: 40554889
Monoacylglycerol lipase (MAGL) represents a key enzyme in the regulation of the endocannabinoid system and arachidonic acid signaling, emerging as a promising target for the treatment of inflammation, neurodegeneration, and cancer. ...Among the synthesized compounds …
Monoacylglycerol lipase (MAGL) represents a key enzyme in the regulation of the endocannabinoid system and arachidonic acid si …
Monoacylglycerol lipase activity in cardiac myocytes.
Severson DL, Hee-Cheong M. Severson DL, et al. Biochem Cell Biol. 1988 Sep;66(9):1013-8. doi: 10.1139/o88-116. Biochem Cell Biol. 1988. PMID: 3190882
Monoacylglycerol lipase activity in homogenates of isolated myocardial cells (myocytes) from rat hearts was recovered in both particulate and soluble subcellular fractions. The activity present in the microsomal (100,000 X g pellet) fraction was solubi …
Monoacylglycerol lipase activity in homogenates of isolated myocardial cells (myocytes) from rat hearts was recovered i …
Chemical probes of endocannabinoid metabolism.
Blankman JL, Cravatt BF. Blankman JL, et al. Pharmacol Rev. 2013 Mar 19;65(2):849-71. doi: 10.1124/pr.112.006387. Print 2013 Apr. Pharmacol Rev. 2013. PMID: 23512546 Free PMC article. Review.
The principal ligands of the endocannabinoid system are the lipid transmitters N-arachidonoylethanolamine (anandamide) and 2-arachidonoylglycerol (2-AG), which activate the two major cannabinoid receptors, CB1 and CB2. Anandamide and 2-AG signaling pathways in the nervous …
The principal ligands of the endocannabinoid system are the lipid transmitters N-arachidonoylethanolamine (anandamide) and 2-arachidonoylgly …
Notoginsenoside R1, a Metabolite from Panax notoginseng, Prevents Paclitaxel-Induced Peripheral Neuropathic Pain in Mice.
Al-Musailem M, Masocha W, Al-Romaiyan A. Al-Musailem M, et al. Molecules. 2025 Sep 4;30(17):3613. doi: 10.3390/molecules30173613. Molecules. 2025. PMID: 40942138 Free PMC article.
One recently discovered key factor in paclitaxel-induced mechanical allodynia (PIMA) pathogenesis is the elevated activity of monoacylglycerol lipase (MAGL), an enzyme that metabolizes the endocannabinoid 2-arachidonoylglycerol (2-AG). ...The effects of NGR1 …
One recently discovered key factor in paclitaxel-induced mechanical allodynia (PIMA) pathogenesis is the elevated activity of mono …
890 results