Most mitochondrial dGTP is tightly bound to respiratory complex I through the NDUFA10 subunit.
Molina-Granada D, González-Vioque E, Dibley MG, Cabrera-Pérez R, Vallbona-Garcia A, Torres-Torronteras J, Sazanov LA, Ryan MT, Cámara Y, Martí R.
Molina-Granada D, et al.
Commun Biol. 2022 Jun 23;5(1):620. doi: 10.1038/s42003-022-03568-6.
Commun Biol. 2022.
PMID: 35739187
Free PMC article.
Here we show that, even under physiological conditions, dGTP is largely overrepresented among other dNTPs in mitochondria of mouse tissues and human cultured cells. In addition, a vast majority of mitochondrial dGTP is tightly bound to NDUFA10, an accessory subunit of comp …
Here we show that, even under physiological conditions, dGTP is largely overrepresented among other dNTPs in mitochondria of mouse tissues a …