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Year Number of Results
2005 1
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2011 2
2012 2
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2017 5
2018 1
2019 5
2020 4
2021 2
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2023 3
2024 1
2025 0

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29 results

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Page 1
Early infection risk in patients with systemic lupus erythematosus treated with rituximab or belimumab from the British Isles Lupus Assessment Group Biologics Register (BILAG-BR): a prospective longitudinal study.
Rodziewicz M, Dyball S, Lunt M, McDonald S, Sutton E, Parker B, Bruce IN; British Isles Lupus Assessment Group Biologics Register (BILAG-BR) consortium. Rodziewicz M, et al. Lancet Rheumatol. 2023 May;5(5):e284-e292. doi: 10.1016/S2665-9913(23)00091-7. Lancet Rheumatol. 2023. PMID: 38251591 Free article.
Across the whole cohort in multivariate analysis, serious infection risk was associated with prednisolone dose (>10 mg; 2.38 [95%CI 1.47-3.84]), hypogammaglobulinaemia (<6 g/L; 2.16 [1.38-3.37]), and multimorbidity (1.45 [1.17-1.80]). Additional concomitant immunosup …
Across the whole cohort in multivariate analysis, serious infection risk was associated with prednisolone dose (>10 mg; 2.38 [95%CI 1.47- …
New Directions in the Management of Peripheral Artery Disease.
Chioncel V, Brezeanu R, Sinescu C. Chioncel V, et al. Am J Ther. 2019 Mar/Apr;26(2):e284-e293. doi: 10.1097/MJT.0000000000000916. Am J Ther. 2019. PMID: 30839377 Review.
Therapeutic options vary depending on the location and severity of the lesions but also on the chronic or acute nature of the disease. Thus, in addition to pharmacological treatment and nonpharmacological measures (related to lifestyle), revascularization therapy is a very …
Therapeutic options vary depending on the location and severity of the lesions but also on the chronic or acute nature of the disease. Thus, …
Structured Neonatal Point-of-Care Ultrasound Training Program.
Kurepa D, Boyar V, Zaghloul N, Beachy J, Zaytseva A, Teng D, Cooper R, Klewer S, Amodio J. Kurepa D, et al. Am J Perinatol. 2021 Aug;38(S 01):e284-e291. doi: 10.1055/s-0040-1709667. Epub 2020 Apr 28. Am J Perinatol. 2021. PMID: 32344442
This study aimed to present the first, innovative, and structured POC US program in neonatal-perinatal medicine field. In addition, we reviewed the availability of the POC US training programs across different medical specialties. ...We defined intuitive educational strate …
This study aimed to present the first, innovative, and structured POC US program in neonatal-perinatal medicine field. In addition, w …
Preclinical characterization of WB737, a potent and selective STAT3 inhibitor, in natural killer/T-cell lymphoma.
Wang Y, Zhou W, Chen J, Chen J, Deng P, Chen H, Sun Y, Yu Z, Pang D, Liu L, Wang P, Hong JH, Teh BT, Huang H, Li W, Yi Z, Lim ST, Chen Y, Ong CK, Liu M, Tan J. Wang Y, et al. MedComm (2020). 2023 Jun 16;4(4):e284. doi: 10.1002/mco2.284. eCollection 2023 Aug. MedComm (2020). 2023. PMID: 37334274 Free PMC article.
Here, we have developed a small molecule drug WB737 as a novel and potent STAT3 inhibitor that directly binds to the STAT3-Src homology 2 domain with high affinity. In addition, the binding affinity of WB737 to STAT3 is 250-fold higher than STAT1 and STAT2. ...
Here, we have developed a small molecule drug WB737 as a novel and potent STAT3 inhibitor that directly binds to the STAT3-Src homology 2 do …
Potential for low-value palliative care of patients with recurrent head and neck cancer.
Nilsen ML, Johnson JT. Nilsen ML, et al. Lancet Oncol. 2017 May;18(5):e284-e289. doi: 10.1016/S1470-2045(17)30260-7. Epub 2017 Apr 26. Lancet Oncol. 2017. PMID: 28456588 Review.
Patients with recurrent cancer bear the burden of these effects along with additional symptoms attributed to the recurrent tumour. To better understand the benefits and burden of palliative treatments for patients with recurrent head and neck cancer, we reviewed the eviden …
Patients with recurrent cancer bear the burden of these effects along with additional symptoms attributed to the recurrent tumour. To …
Locoregional Recurrent or Second Primary Head and Neck Cancer: Management Strategies and Challenges.
Wong SJ, Heron DE, Stenson K, Ling DC, Vargo JA. Wong SJ, et al. Am Soc Clin Oncol Educ Book. 2016;35:e284-92. doi: 10.1200/EDBK_157804. Am Soc Clin Oncol Educ Book. 2016. PMID: 27249734 Free article. Review.
Postoperative treatment is frequently warranted but carries significant risk. In addition, the rapid rise in the incidence of HPV-associated HNSCC raises the question of whether established treatment paradigms should be re-examined in this population of patients with a muc …
Postoperative treatment is frequently warranted but carries significant risk. In addition, the rapid rise in the incidence of HPV-ass …
Foot-and-Mouth Disease Virus Counteracts on Internal Ribosome Entry Site Suppression by G3BP1 and Inhibits G3BP1-Mediated Stress Granule Assembly via Post-Translational Mechanisms.
Ye X, Pan T, Wang D, Fang L, Ma J, Zhu X, Shi Y, Zhang K, Zheng H, Chen H, Li K, Xiao S. Ye X, et al. Front Immunol. 2018 May 25;9:1142. doi: 10.3389/fimmu.2018.01142. eCollection 2018. Front Immunol. 2018. PMID: 29887867 Free PMC article.
To counteract these host protective responses, FMDV-induced dephosphorylation of G3BP1, compromising its inhibitory effect on viral IRES. In addition, FMDV also proteolytically cleaved G3BP1 by its 3C protease (3C(pro)). G3BP1 was cleaved at glutamic acid-284 (E284) …
To counteract these host protective responses, FMDV-induced dephosphorylation of G3BP1, compromising its inhibitory effect on viral IRES. In …
Evidence for the diagnosis and treatment of acute uncomplicated sinusitis in children: a systematic review.
Smith MJ. Smith MJ. Pediatrics. 2013 Jul;132(1):e284-96. doi: 10.1542/peds.2013-1072. Pediatrics. 2013. PMID: 23796734 Review.
However, qualitative analysis of these studies suggests that children with greater severity of illness at presentation are more likely to benefit from antimicrobial therapy. An additional 5 trials compared different antimicrobial therapies but did not include placebo group …
However, qualitative analysis of these studies suggests that children with greater severity of illness at presentation are more likely to be …
Cost-Effectiveness and Clinical Outcome of Transcatheter Versus Sutureless Aortic Valve Replacement.
Indelen C, Bas T, Kar A, Ergenç E, Karademir BC, Sismanoglu M, Kirali K. Indelen C, et al. Heart Surg Forum. 2023 Jun 25;26(3):E284-E291. doi: 10.1532/hsf.5445. Heart Surg Forum. 2023. PMID: 37401432
It is stated that the SU-AVR method provides an additional 1.14 Quality-Adjusted Life Year (QALY) compared to the TAVI method. The TAVI was more expensive than the SU-AVR in our study, but the difference was not statistically significant ($40,520.62 vs. $38,405.62, p > …
It is stated that the SU-AVR method provides an additional 1.14 Quality-Adjusted Life Year (QALY) compared to the TAVI method. The TA …
29 results