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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1966 1
1967 4
1968 2
1970 2
1971 3
1972 6
1974 2
1975 16
1976 11
1977 17
1978 10
1979 12
1980 17
1981 15
1982 13
1983 20
1984 24
1985 8
1986 18
1987 14
1988 28
1989 18
1990 27
1991 19
1992 30
1993 21
1994 43
1995 42
1996 62
1997 110
1998 87
1999 117
2000 145
2001 137
2002 175
2003 186
2004 203
2005 245
2006 254
2007 311
2008 316
2009 318
2010 319
2011 433
2012 471
2013 511
2014 517
2015 592
2016 605
2017 761
2018 795
2019 961
2020 515
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8,601 results
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Page 1
Adeno-associated virus (AAV) vectors in cancer gene therapy.
Santiago-Ortiz JL, Schaffer DV. Santiago-Ortiz JL, et al. J Control Release. 2016 Oct 28;240:287-301. doi: 10.1016/j.jconrel.2016.01.001. Epub 2016 Jan 12. J Control Release. 2016. PMID: 26796040 Free PMC article. Review.
Gene delivery vectors based on adeno-associated virus (AAV) have been utilized in a large number of gene therapy clinical trials, which have demonstrated their strong safety profile and increasingly their therapeutic efficacy for treating monogenic dis …
Gene delivery vectors based on adeno-associated virus (AAV) have been utilized in a large number of gene therapy …
Emerging Issues in AAV-Mediated In Vivo Gene Therapy.
Colella P, Ronzitti G, Mingozzi F. Colella P, et al. Mol Ther Methods Clin Dev. 2017 Dec 1;8:87-104. doi: 10.1016/j.omtm.2017.11.007. eCollection 2018 Mar 16. Mol Ther Methods Clin Dev. 2017. PMID: 29326962 Free PMC article. Review.
In recent years, the number of clinical trials in which adeno-associated virus (AAV) vectors have been used for in vivo gene transfer has steadily increased. ...In this review, we will give an overview on the biology of AAV vector, discuss the d …
In recent years, the number of clinical trials in which adeno-associated virus (AAV) vectors have been used for …
Basic biology of adeno-associated virus (AAV) vectors used in gene therapy.
Balakrishnan B, Jayandharan GR. Balakrishnan B, et al. Curr Gene Ther. 2014;14(2):86-100. doi: 10.2174/1566523214666140302193709. Curr Gene Ther. 2014. PMID: 24588706 Review.
Adeno-associated virus (AAV) based vectors have emerged as important tools for gene therapy in humans. The recent successes seen in Phase I/II clinical trials have also highlighted the issues related to the host and vector-related immune response that
Adeno-associated virus (AAV) based vectors have emerged as important tools for gene therapy in humans. The recen
Adeno-associated Virus (AAV) Dual Vector Strategies for Gene Therapy Encoding Large Transgenes.
McClements ME, MacLaren RE. McClements ME, et al. Yale J Biol Med. 2017 Dec 19;90(4):611-623. eCollection 2017 Dec. Yale J Biol Med. 2017. PMID: 29259525 Free PMC article. Review.
The use of adeno-associated viral (AAV) vectors for gene therapy treatments of inherited disorders has accelerated over the past decade with multiple clinical trials ongoing in varying tissue types and new ones initiating every year. ...Due to this problem, y …
The use of adeno-associated viral (AAV) vectors for gene therapy treatments of inherited disorders has accelerated over …
Adeno-Associated Virus (AAV) Vectors: Rational Design Strategies for Capsid Engineering.
Lee EJ, Guenther CM, Suh J. Lee EJ, et al. Curr Opin Biomed Eng. 2018 Sep;7:58-63. doi: 10.1016/j.cobme.2018.09.004. Epub 2018 Sep 26. Curr Opin Biomed Eng. 2018. PMID: 31106283 Free PMC article.
Adeno-associated virus (AAV) consists of a simple genome, infects mammalian cells, displays nonpathogenicity in humans, and spans an array of serotypes and variants bearing distinct tissue tropisms. These attributes lend AAV tremendous promise a
Adeno-associated virus (AAV) consists of a simple genome, infects mammalian cells, displays nonpathogenicity in
High-Throughput Dissection of AAV-Host Interactions: The Fast and the Curious.
Herrmann AK, Grimm D. Herrmann AK, et al. J Mol Biol. 2018 Aug 17;430(17):2626-2640. doi: 10.1016/j.jmb.2018.05.022. Epub 2018 May 19. J Mol Biol. 2018. PMID: 29782834 Review.
Over 50 years after its initial description, adeno-associated virus (AAV) remains the most exciting but also most elusive study object in basic or applied virology. ...On the other hand, it is striking to witness a recent flurry of reports that highlig …
Over 50 years after its initial description, adeno-associated virus (AAV) remains the most exciting but also mos …
The role of infection in miscarriage.
Giakoumelou S, Wheelhouse N, Cuschieri K, Entrican G, Howie SE, Horne AW. Giakoumelou S, et al. Hum Reprod Update. 2016 Jan-Feb;22(1):116-33. doi: 10.1093/humupd/dmv041. Epub 2015 Sep 19. Hum Reprod Update. 2016. PMID: 26386469 Free PMC article. Review.
Q fever, adeno-associated virus, Bocavirus, Hepatitis C and Mycoplasma genitalium infections do not appear to affect pregnancy outcome. The effects of Chlamydia trachomatis, Toxoplasma gondii, human papillomavirus, herpes simplex virus, parvo
Q fever, adeno-associated virus, Bocavirus, Hepatitis C and Mycoplasma genitalium infections do not appear to af …
Accurate and Rapid Sequence Analysis of Adeno-Associated Virus Plasmids by Illumina Next-Generation Sequencing.
Saveliev A, Liu J, Li M, Hirata L, Latshaw C, Zhang J, Wilson JM. Saveliev A, et al. Hum Gene Ther Methods. 2018 Oct;29(5):201-211. doi: 10.1089/hgtb.2018.037. Epub 2018 Aug 22. Hum Gene Ther Methods. 2018. PMID: 30051733
Sequence validation of plasmid DNA is a crucial quality control step that must occur prior to adeno-associated virus (AAV) vector packaging through plasmid transfection. AAV cis-plasmids present unique challenges to sequence analysis, as they co …
Sequence validation of plasmid DNA is a crucial quality control step that must occur prior to adeno-associated virus ( …
Small But Increasingly Mighty: Latest Advances in AAV Vector Research, Design, and Evolution.
Grimm D, Büning H. Grimm D, et al. Hum Gene Ther. 2017 Nov;28(11):1075-1086. doi: 10.1089/hum.2017.172. Epub 2017 Aug 23. Hum Gene Ther. 2017. PMID: 28835125 Review.
Recombinant gene delivery vectors derived from naturally occurring or genetically engineered adeno-associated viruses (AAV) have taken center stage in human gene therapy, fueled by rapidly accumulating and highly encouraging clinical data. ...Fortunately, in …
Recombinant gene delivery vectors derived from naturally occurring or genetically engineered adeno-associated viruses (AAV
Design of AAV Vectors for Delivery of Large or Multiple Transgenes.
Patel A, Zhao J, Duan D, Lai Y. Patel A, et al. Methods Mol Biol. 2019;1950:19-33. doi: 10.1007/978-1-4939-9139-6_2. Methods Mol Biol. 2019. PMID: 30783966 Review.
Adeno-associated virus (AAV)-mediated gene therapy has evolved from bench to bedside, and now is the therapy of choice for certain inherited diseases. ...Multiple strategies, including split AAV gene delivery and oversized AAV gene delive
Adeno-associated virus (AAV)-mediated gene therapy has evolved from bench to bedside, and now is the therapy of
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