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Year Number of Results
1979 1
1983 4
1985 1
1986 1
1987 1
1988 1
1990 1
1991 2
1995 1
1997 1
1998 1
2000 5
2003 1
2004 1
2005 2
2006 1
2007 1
2008 1
2009 4
2010 1
2011 1
2013 1
2014 1
2016 2
2017 1
2018 1
2020 3
2021 0
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Identification of adrafinil and its main metabolite modafinil in human hair. Self-administration study and interpretation of an authentic case.
Ameline A, Gheddar L, Raul JS, Kintz P. Ameline A, et al. Forensic Sci Res. 2020 Jan 29;5(4):322-326. doi: 10.1080/20961790.2019.1704482. Forensic Sci Res. 2020. PMID: 33457050 Free PMC article.
The World Anti-Doping Agency (WADA) banned these two drugs in sports in 2004. The authors report an authentic case involving adrafinil and modafinil. The laboratory was requested to test for adrafinil in a hair strand collected from a woman found in possession of vi …
The World Anti-Doping Agency (WADA) banned these two drugs in sports in 2004. The authors report an authentic case involving adrafinil
Adrafinil-induced orofacial dyskinesia.
Thobois S, Xie J, Mollion H, Benatru I, Broussolle E. Thobois S, et al. Mov Disord. 2004 Aug;19(8):965-6. doi: 10.1002/mds.20154. Mov Disord. 2004. PMID: 15300665
We describe the first case of orofacial abnormal movements induced by adrafinil, a vigilance promoting agent of the same pharmacological class as modafinil. The dyskinesias did not spontaneously recover despite adrafinil withdrawal for a 4-month period. They were se …
We describe the first case of orofacial abnormal movements induced by adrafinil, a vigilance promoting agent of the same pharmacologi …
Adrafinil disrupts performance on a delayed nonmatching-to-position task in aged beagle dogs.
Siwak CT, Tapp PD, Milgram NW. Siwak CT, et al. Pharmacol Biochem Behav. 2003 Aug;76(1):161-8. doi: 10.1016/s0091-3057(03)00211-9. Pharmacol Biochem Behav. 2003. PMID: 13679229
We wanted to further explore the cognitive effects of adrafinil in dogs. The purpose of the present study was to determine the effect of oral administration of adrafinil on visuospatial function in dogs. Eighteen aged beagle dogs were tested on a delayed nonmatching …
We wanted to further explore the cognitive effects of adrafinil in dogs. The purpose of the present study was to determine the effect …
Adrafinil: effects on behavior and cognition in aged canines.
Siwak CT, Callahan H, Milgram NW. Siwak CT, et al. Prog Neuropsychopharmacol Biol Psychiatry. 2000 Jul;24(5):709-26. doi: 10.1016/s0278-5846(00)00103-2. Prog Neuropsychopharmacol Biol Psychiatry. 2000. PMID: 11191710
Acquisition of a size discrimination problem is enhanced by adrafinil. This may be linked to performance motivation. 5. Adrafinil causes a long-lasting increase in high frequency electroencephalographic activity recorded from cortical electrodes. 6. These results in …
Acquisition of a size discrimination problem is enhanced by adrafinil. This may be linked to performance motivation. 5. Adrafinil
Behavioral activating effects of adrafinil in aged canines.
Siwak CT, Gruet P, Woehrlé F, Schneider M, Muggenburg BA, Murphey HL, Callahan H, Milgram NW. Siwak CT, et al. Pharmacol Biochem Behav. 2000 Jun;66(2):293-300. doi: 10.1016/s0091-3057(00)00188-x. Pharmacol Biochem Behav. 2000. PMID: 10880681
Adrafinil also caused a transient increase in directed sniffing. At the highest dose level, adrafinil caused a decrease in urination frequency. ...The individual differences were correlated with changes in serum levels of adrafinil 10 h following treatment...
Adrafinil also caused a transient increase in directed sniffing. At the highest dose level, adrafinil caused a decrease in uri
Fluorescent zinc and copper complexes for detection of adrafinil in paper-based microfluidic devices.
Caglayan MG, Sheykhi S, Mosca L, Anzenbacher P. Caglayan MG, et al. Chem Commun (Camb). 2016 Jul 7;52(53):8279-82. doi: 10.1039/c6cc03640f. Epub 2016 Jun 13. Chem Commun (Camb). 2016. PMID: 27293080
We show that fluorescent coordinatively unsaturated metal complexes can recognize various Lewis bases while providing an easy-to-detect fluorescence response. This approach is applied to the detection of adrafinil, a banned performance-enhancing drug....
We show that fluorescent coordinatively unsaturated metal complexes can recognize various Lewis bases while providing an easy-to-detect fluo …
Oral administration of adrafinil improves discrimination learning in aged beagle dogs.
Milgram NW, Siwak CT, Gruet P, Atkinson P, Woehrlé F, Callahan H. Milgram NW, et al. Pharmacol Biochem Behav. 2000 Jun;66(2):301-5. doi: 10.1016/s0091-3057(00)00175-1. Pharmacol Biochem Behav. 2000. PMID: 10880682
An effect of adrafinil on motivation may partially account for these findings; however, adrafinil did not significantly affect response latency. Adrafinil is believed to serve as an alpha-1 adrenoceptor agonist. ...
An effect of adrafinil on motivation may partially account for these findings; however, adrafinil did not significantly affect …
Doping control analysis for adrafinil and its major metabolites in human urine.
Lu J, Wang X, Yang S, Liu X, Qin Y, Shen L, Wu Y, Xu Y, Wu M, Ouyang G. Lu J, et al. Rapid Commun Mass Spectrom. 2009 Jun;23(11):1592-600. doi: 10.1002/rcm.4044. Rapid Commun Mass Spectrom. 2009. PMID: 19399790
A new and reliable two-step liquid chromatography/tandem mass spectrometry (LC/MS/MS) method in combination with gas chromatography/mass spectrometry (GC/MS) for the screening and confirmation of adrafinil and its major metabolites, modafinil and modafinil acid, in human u …
A new and reliable two-step liquid chromatography/tandem mass spectrometry (LC/MS/MS) method in combination with gas chromatography/mass spe …
LC-ESI-MS determination and pharmacokinetics of adrafinil in rats.
Rao RN, Shinde DD, Talluri MV, Agawane SB. Rao RN, et al. J Chromatogr B Analyt Technol Biomed Life Sci. 2008 Sep 15;873(1):119-23. doi: 10.1016/j.jchromb.2008.07.025. Epub 2008 Jul 29. J Chromatogr B Analyt Technol Biomed Life Sci. 2008. PMID: 18723408
The assay was specific, accurate (R.S.D.<2.6%), precise and reproducible (within- and between-day precisions R.S.D. <7.0% and <9.0%, respectively). Adrafinil in rat serum was stable over three freeze-thaw cycles at ambient temperature for 6 h. The method had a low …
The assay was specific, accurate (R.S.D.<2.6%), precise and reproducible (within- and between-day precisions R.S.D. <7.0% and <9.0% …
Effect of modafinil on pancreatic exocrine secretion in rats. A comparison with adrafinil and related drugs.
Chariot J, Appia F, Vaille C, Rozé C. Chariot J, et al. Fundam Clin Pharmacol. 1987;1(4):243-52. doi: 10.1111/j.1472-8206.1987.tb00563.x. Fundam Clin Pharmacol. 1987. PMID: 2893764
In conscious rats, modafinil and adrafinil inhibited the output of protein in the basal interdigestive pancreatic secretion. Modafinil was more active than adrafinil as an inhibitor of pancreatic secretion. The effects of modafinil and adrafinil were differen …
In conscious rats, modafinil and adrafinil inhibited the output of protein in the basal interdigestive pancreatic secretion. Modafini …
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