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63 results

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Page 1
A Randomized Trial of Drug Route in Out-of-Hospital Cardiac Arrest.
Couper K, Ji C, Deakin CD, Fothergill RT, Nolan JP, Long JB, Mason JM, Michelet F, Norman C, Nwankwo H, Quinn T, Slowther AM, Smyth MA, Starr KR, Walker A, Wood S, Bell S, Bradley G, Brown M, Brown S, Burrow E, Charlton K, Claxton Dip A, Dra'gon V, Evans C, Falloon J, Foster T, Kearney J, Lang N, Limmer M, Mellett-Smith A, Miller J, Mills C, Osborne R, Rees N, Spaight RES, Squires GL, Tibbetts B, Waddington M, Whitley GA, Wiles JV, Williams J, Wiltshire S, Wright A, Lall R, Perkins GD; PARAMEDIC-3 Collaborators. Couper K, et al. N Engl J Med. 2025 Jan 23;392(4):336-348. doi: 10.1056/NEJMoa2407780. Epub 2024 Oct 31. N Engl J Med. 2025. PMID: 39480216 Free PMC article. Clinical Trial.
BACKGROUND: In patients with out-of-hospital cardiac arrest, the effectiveness of drugs such as epinephrine is highly time-dependent. ...During the trial, one adverse event, which occurred in the intraosseous group, was reported. CONCLUSI …
BACKGROUND: In patients with out-of-hospital cardiac arrest, the effectiveness of drugs such as epinep …
A Randomized Trial of Epinephrine in Out-of-Hospital Cardiac Arrest.
Perkins GD, Ji C, Deakin CD, Quinn T, Nolan JP, Scomparin C, Regan S, Long J, Slowther A, Pocock H, Black JJM, Moore F, Fothergill RT, Rees N, O'Shea L, Docherty M, Gunson I, Han K, Charlton K, Finn J, Petrou S, Stallard N, Gates S, Lall R; PARAMEDIC2 Collaborators. Perkins GD, et al. N Engl J Med. 2018 Aug 23;379(8):711-721. doi: 10.1056/NEJMoa1806842. Epub 2018 Jul 18. N Engl J Med. 2018. PMID: 30021076 Free article. Clinical Trial.
BACKGROUND: Concern about the use of epinephrine as a treatment for out-of-hospital cardiac arrest led the International Liaison Committee on Resuscitation to call for a placebo-controlled trial to determine whether the use of epinephr …
BACKGROUND: Concern about the use of epinephrine as a treatment for out-of-hospital cardiac arrest …
Intraosseous or Intravenous Vascular Access for Out-of-Hospital Cardiac Arrest.
Vallentin MF, Granfeldt A, Klitgaard TL, Mikkelsen S, Folke F, Christensen HC, Povlsen AL, Petersen AH, Winther S, Frilund LW, Meilandt C, Holmberg MJ, Winther KB, Bach A, Dissing TH, Terkelsen CJ, Christensen S, Kirkegaard Rasmussen L, Mortensen LR, Loldrup ML, Elkmann T, Nielsen AG, Runge C, Klæstrup E, Holm JH, Bak M, Nielsen LR, Pedersen M, Kjærgaard-Andersen G, Hansen PM, Brøchner AC, Christensen EF, Nielsen FM, Nissen CG, Bjørn JW, Burholt P, Obling LER, Holle SLD, Russell L, Alstrøm H, Hestad S, Fogtmann TH, Buciek JUH, Jakobsen K, Krag M, Sandgaard M, Sindberg B, Andersen LW. Vallentin MF, et al. N Engl J Med. 2025 Jan 23;392(4):349-360. doi: 10.1056/NEJMoa2407616. Epub 2024 Oct 31. N Engl J Med. 2025. PMID: 39480221 Clinical Trial.
BACKGROUND: Out-of-hospital cardiac arrest is a leading cause of death worldwide. Establishing vascular access is critical for administering guideline-recommended drugs during cardiopulmonary resuscitation. ...METHODS: We conducted a randomized …
BACKGROUND: Out-of-hospital cardiac arrest is a leading cause of death worldwide. Establishing vascular a …
Effect of Intravenous or Intraosseous Calcium vs Saline on Return of Spontaneous Circulation in Adults With Out-of-Hospital Cardiac Arrest: A Randomized Clinical Trial.
Vallentin MF, Granfeldt A, Meilandt C, Povlsen AL, Sindberg B, Holmberg MJ, Iversen BN, Mærkedahl R, Mortensen LR, Nyboe R, Vandborg MP, Tarpgaard M, Runge C, Christiansen CF, Dissing TH, Terkelsen CJ, Christensen S, Kirkegaard H, Andersen LW. Vallentin MF, et al. JAMA. 2021 Dec 14;326(22):2268-2276. doi: 10.1001/jama.2021.20929. JAMA. 2021. PMID: 34847226 Free PMC article. Clinical Trial.
IMPORTANCE: It is unclear whether administration of calcium has a beneficial effect in patients with cardiac arrest. OBJECTIVE: To determine whether administration of calcium during out-of-hospital cardiac arrest improves return of …
IMPORTANCE: It is unclear whether administration of calcium has a beneficial effect in patients with cardiac arrest. OBJECTIVE …
Landiolol for refractory ventricular fibrillation in out-of-hospital cardiac arrest: A randomized, double-blind, placebo-controlled, pilot trial.
Gelbenegger G, Jilma B, Horvath LC, Schoergenhofer C, Siller-Matula JM, Sulzgruber P, Grassmann D, Hamp T, Grafeneder J, Schnaubelt S, Holzer M, Krammel M. Gelbenegger G, et al. Resuscitation. 2024 Aug;201:110273. doi: 10.1016/j.resuscitation.2024.110273. Epub 2024 Jun 10. Resuscitation. 2024. PMID: 38866231 Free article. Clinical Trial.
BACKGROUND: Out-of-hospital cardiac arrest (OHCA) complicated by refractory ventricular fibrillation (VF) is associated with poor outcome. Beta-1-receptor selective blockade might overcome refractory VF and improve survival. This trial in …
BACKGROUND: Out-of-hospital cardiac arrest (OHCA) complicated by refractory ventricular fibrillation (VF) …
Adrenaline to improve survival in out-of-hospital cardiac arrest: the PARAMEDIC2 RCT.
Perkins GD, Ji C, Achana F, Black JJ, Charlton K, Crawford J, de Paeztron A, Deakin C, Docherty M, Finn J, Fothergill RT, Gates S, Gunson I, Han K, Hennings S, Horton J, Khan K, Lamb S, Long J, Miller J, Moore F, Nolan J, O'Shea L, Petrou S, Pocock H, Quinn T, Rees N, Regan S, Rosser A, Scomparin C, Slowther A, Lall R. Perkins GD, et al. Health Technol Assess. 2021 Apr;25(25):1-166. doi: 10.3310/hta25250. Health Technol Assess. 2021. PMID: 33861194 Free PMC article. Clinical Trial.

SETTING: This trial was set in five NHS ambulance services in England and Wales. PARTICIPANTS: Adults treated for an out-of-hospital cardiac arrest were included. Patients were ineligible if they were pregnant, if they were aged < 16 years, i

…
SETTING: This trial was set in five NHS ambulance services in England and Wales. PARTICIPANTS: Adults treated for an out-of- …
Augmented-Medication CardioPulmonary Resuscitation Trials in out-of-hospital cardiac arrest: a pilot randomized controlled trial.
Kim JS, Ryoo SM, Kim YJ, Sohn CH, Ahn S, Seo DW, Hong SI, Kim SM, Chae B, Kim WY. Kim JS, et al. Crit Care. 2022 Dec 7;26(1):378. doi: 10.1186/s13054-022-04248-x. Crit Care. 2022. PMID: 36476543 Free PMC article. Clinical Trial.
We hypothesize that Augmented-Medication CardioPulmonary Resuscitation could be helpful for selected patients with out-of-hospital cardiac arrest (OHCA). METHODS: This is a double-blind, single-center, randomized, placebo-controlled trial conduc …
We hypothesize that Augmented-Medication CardioPulmonary Resuscitation could be helpful for selected patients with out-of-h …
Pediatric Out-of-Hospital Cardiac Arrest Characteristics and Their Association With Survival and Neurobehavioral Outcome.
Meert KL, Telford R, Holubkov R, Slomine BS, Christensen JR, Dean JM, Moler FW; Therapeutic Hypothermia after Pediatric Cardiac Arrest (THAPCA) Trial Investigators. Meert KL, et al. Pediatr Crit Care Med. 2016 Dec;17(12):e543-e550. doi: 10.1097/PCC.0000000000000969. Pediatr Crit Care Med. 2016. PMID: 27679965 Free PMC article. Clinical Trial.
OBJECTIVE: To investigate relationships between cardiac arrest characteristics and survival and neurobehavioral outcome among children recruited to the Therapeutic Hypothermia after Pediatric Cardiac Arrest Out-of-Hospital t …
OBJECTIVE: To investigate relationships between cardiac arrest characteristics and survival and neurobehavioral outcome …
Effects of Shenfu injection on survival and neurological outcome after out-of-hospital cardiac arrest: A randomised controlled trial.
Shao F, Li H, Li D, Li C. Shao F, et al. Resuscitation. 2020 May;150:139-144. doi: 10.1016/j.resuscitation.2019.11.010. Epub 2019 Nov 23. Resuscitation. 2020. PMID: 31770574 Clinical Trial.
AIM: We aimed to assess the effects of Shenfu injection (SFI) in combination with epinephrine during cardiac arrest on survival and neurological outcome after out-of-hospital cardiac arrest (OHCA). ...RESULTS: In both …
AIM: We aimed to assess the effects of Shenfu injection (SFI) in combination with epinephrine during cardiac arrest on …
Effect of adrenaline on survival in out-of-hospital cardiac arrest: A randomised double-blind placebo-controlled trial.
Jacobs IG, Finn JC, Jelinek GA, Oxer HF, Thompson PL. Jacobs IG, et al. Resuscitation. 2011 Sep;82(9):1138-43. doi: 10.1016/j.resuscitation.2011.06.029. Epub 2011 Jul 2. Resuscitation. 2011. PMID: 21745533 Clinical Trial.
BACKGROUND: There is little evidence from clinical trials that the use of adrenaline (epinephrine) in treating cardiac arrest improves survival, despite adrenaline being considered standard of care for many decades. The aim of our study w …
BACKGROUND: There is little evidence from clinical trials that the use of adrenaline (epinephrine) in treating cardiac …
63 results