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Multi-omics analysis reveal clinical-gut-brain interactions in female ibs patients with adverse childhood experiences.
Binod M, Chang L, Hung MW, Dong TS, Kilpatrick LA, Tomasevic A, Choy M, Shin A, Mayer EA, Church A. Binod M, et al. Biol Sex Differ. 2025 Nov 25;16(1):101. doi: 10.1186/s13293-025-00757-w. Biol Sex Differ. 2025. PMID: 41291881 Free PMC article.
Adverse childhood experiences (ACE) increase the risk and severity of IBS, likely by amplifying stress responsiveness and gut-brain dysfunction in females. ...This study explores how adverse childhood experiences (ACE) impact IB …
Adverse childhood experiences (ACE) increase the risk and severity of IBS, likely by amplifying stress responsiv …
Adverse childhood experiences and alexithymia intensity as predictors of temporal dynamics of functioning in individuals with irritable bowel syndrome: A three-wave latent transition analysis.
Rzeszutek M, Kowalkowska J, Drabarek K, Van Hoy A, Schier K, Lis-Turlejska M, Dragan M, Holas P, Maison D, Litwin E, Wawrzyniak J, Znamirowska W, Szumiał S, Desmond M. Rzeszutek M, et al. J Psychosom Res. 2024 Dec;187:111904. doi: 10.1016/j.jpsychores.2024.111904. Epub 2024 Aug 23. J Psychosom Res. 2024. PMID: 39298867 Free article.
This prospective study explored whether early life factors (adverse childhood experiences; ACEs) and alexithymia intensity, could explain IBS symptom severity and its effects on psychological functioning over time. ...The IBS sample completed th …
This prospective study explored whether early life factors (adverse childhood experiences; ACEs) and alexithymia intens …
Adverse Childhood Experiences and Their Effect on Irritable Bowel Syndrome Among Saudi Arabian Adults.
Alsubaie MA, Alkhalifah HA, Ali AH, Bahabri MA, Alharbi BA, Alfakeh SA. Alsubaie MA, et al. Cureus. 2022 Jun 9;14(6):e25791. doi: 10.7759/cureus.25791. eCollection 2022 Jun. Cureus. 2022. PMID: 35812574 Free PMC article.
Background Adverse childhood experiences (ACEs) are traumatic events that occur before 18 years of age. ACEs have been associated with many negative health problems, including the development of chronic diseases, such as irritable bowel syndrome (IBS), …
Background Adverse childhood experiences (ACEs) are traumatic events that occur before 18 years of age. ACEs have been …
Association of adverse childhood experiences with irritable bowel syndrome in Mexican adults: A cross-sectional study.
Priego-Parra BA, Triana-Romero A, Lajud-Barquín FA, de Fátima Higuera-DelaTijera M, Martínez-Vázquez SE, Salgado-Álvarez GA, García-Mora U, Cruz-Márquez MÁ, Cano-Contreras AD, Cid HV, Remes-Troche JM. Priego-Parra BA, et al. Neurogastroenterol Motil. 2024 Mar;36(3):e14743. doi: 10.1111/nmo.14743. Epub 2024 Jan 19. Neurogastroenterol Motil. 2024. PMID: 38243398
BACKGROUND: Adverse childhood experiences (ACEs) are linked to the development of gastrointestinal disorders during adulthood, but there is limited research on the prevalence of ACEs in Latin American populations. ...All participants completed four self-repor …
BACKGROUND: Adverse childhood experiences (ACEs) are linked to the development of gastrointestinal disorders during adu …
Association of history of adverse childhood experiences with irritable bowel syndrome (IBS) in individuals with mood disorders.
Rosenblat JD, Mansur RB, Brietzke E, Kennedy SH, Carvalho AF, Lee Y, Subramaniapillai M, Muzina DJ, Dale R, Tamura JK, Lui LMW, Park C, Phan L, Tuineag RM, McIntyre RS. Rosenblat JD, et al. Psychiatry Res. 2020 Jun;288:112967. doi: 10.1016/j.psychres.2020.112967. Epub 2020 Apr 17. Psychiatry Res. 2020. PMID: 32339805
The objective of the current study was to assess the association between adverse childhood experiences (ACEs) and irritable bowel syndrome (IBS) in mood disorder patients. ...In the MDD subgroup, ACEs (all categories and individual categories) were not …
The objective of the current study was to assess the association between adverse childhood experiences (ACEs) and irrit …
Relationship between adverse childhood experiences and illness anxiety in irritable bowel syndrome - The impact of gender.
Berens S, Banzhaf P, Baumeister D, Gauss A, Eich W, Schaefert R, Tesarz J. Berens S, et al. J Psychosom Res. 2020 Jan;128:109846. doi: 10.1016/j.jpsychores.2019.109846. Epub 2019 Oct 19. J Psychosom Res. 2020. PMID: 31759196

Compared to HCs, IBS patients were characterized by higher prevalences for adverse childhood experiences (63.8% vs. 48.0%, p = .02, OR = 1.33) and increased levels of illness anxiety (p < .001, eta(2) = 0.595). Taking into account gender specific ef

…
Compared to HCs, IBS patients were characterized by higher prevalences for adverse childhood experiences (63.8% …
Adverse childhood experiences are associated with irritable bowel syndrome and gastrointestinal symptom severity.
Park SH, Videlock EJ, Shih W, Presson AP, Mayer EA, Chang L. Park SH, et al. Neurogastroenterol Motil. 2016 Aug;28(8):1252-60. doi: 10.1111/nmo.12826. Epub 2016 Apr 8. Neurogastroenterol Motil. 2016. PMID: 27061107 Free PMC article.
BACKGROUND: Early adverse life events (EALs) are associated with irritable bowel syndrome (IBS). Exposure to EALs as assessed by the Adverse Childhood Experiences (ACE) questionnaire is associated with greater disease prevalence, but ACE has not …
BACKGROUND: Early adverse life events (EALs) are associated with irritable bowel syndrome (IBS). Exposure to EALs as assessed …
Role of Sex, Anxiety, and Resilience in the Association Between Adverse Childhood Experiences and Irritable Bowel Syndrome.
Lee AH, Mahurkar-Joshi S, Naliboff B, Gupta A, Labus J, Tillisch K, Mayer E, Chang L. Lee AH, et al. Clin Gastroenterol Hepatol. 2025 Jan;23(1):154-162.e2. doi: 10.1016/j.cgh.2024.05.041. Epub 2024 Jun 13. Clin Gastroenterol Hepatol. 2025. PMID: 38878847 Free PMC article.
BACKGROUND & AIMS: Adverse childhood experiences (ACE) are associated with increased risk of irritable bowel syndrome (IBS), a female-predominant chronic abdominal disorder. ...We compared sex differences in ACE for adults with and without IBS …
BACKGROUND & AIMS: Adverse childhood experiences (ACE) are associated with increased risk of irritable bowel syndro …
Resilience in the face of adversity: Adverse and benevolent childhood experiences in irritable bowel syndrome.
Anumolu A, Hamal A, Petrovski R, Acker E, Buck S, Hutt T, Momodu I, Okafor C, van Tilburg MAL. Anumolu A, et al. J Psychosom Res. 2026 Sep;208:112847. doi: 10.1016/j.jpsychores.2026.112847. Epub 2026 May 5. J Psychosom Res. 2026. PMID: 42119244
OBJECTIVE: Patients with irritable bowel syndrome (IBS) report higher levels of Adverse Childhood Experiences (ACE). However, little is known about protective factors. ...No interaction effect was found for GI symptom severity (GSRS), indicating the ef …
OBJECTIVE: Patients with irritable bowel syndrome (IBS) report higher levels of Adverse Childhood Experiences (A …
Long-term risk of irritable bowel syndrome associated with adverse childhood and adulthood experiences: a large-scale prospective cohort study.
Zhou Y, Liu S, Xie S, Zhang Q, Zhang S, Zhu S, Wu S. Zhou Y, et al. Transl Psychiatry. 2026 Jan 28;16(1):70. doi: 10.1038/s41398-026-03833-w. Transl Psychiatry. 2026. PMID: 41605903 Free PMC article.
The impact of adverse childhood experiences (ACEs), adverse adulthood experiences (AAEs), and their combined effects on the risk of incident irritable bowel syndrome (IBS) remains unclear. We aimed to investigate the risk of IBS as …
The impact of adverse childhood experiences (ACEs), adverse adulthood experiences (AAEs), and their combi …
24 results