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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1965 2
1969 1
1970 1
1975 1
1976 1
1977 2
1978 2
1979 2
1980 3
1981 2
1982 2
1983 3
1984 4
1985 7
1986 6
1987 4
1988 10
1989 5
1990 10
1991 6
1992 11
1993 9
1994 8
1995 15
1996 17
1997 16
1998 23
1999 17
2000 25
2001 37
2002 35
2003 26
2004 34
2005 24
2006 36
2007 33
2008 54
2009 48
2010 38
2011 48
2012 57
2013 65
2014 64
2015 72
2016 79
2017 69
2018 81
2019 55
2020 30
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1,081 results
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Page 1
Do glutathione levels decline in aging human brain?
Tong J, Fitzmaurice PS, Moszczynska A, Mattina K, Ang LC, Boileau I, Furukawa Y, Sailasuta N, Kish SJ. Tong J, et al. Free Radic Biol Med. 2016 Apr;93:110-7. doi: 10.1016/j.freeradbiomed.2016.01.029. Epub 2016 Feb 1. Free Radic Biol Med. 2016. PMID: 26845616
Our objective was to establish whether advancing age is associated with glutathione deficiency in human brain. We measured reduced glutathione (GSH) levels in multiple regions of autopsied brain of normal subjects (n=74) aged one day to 99 years. ...To …
Our objective was to establish whether advancing age is associated with glutathione deficiency in human brain. We measured red …
Application of Glutathione as Anti-Oxidative and Anti-Aging Drugs.
Homma T, Fujii J. Homma T, et al. Curr Drug Metab. 2015;16(7):560-71. doi: 10.2174/1389200216666151015114515. Curr Drug Metab. 2015. PMID: 26467067 Review.
Glutathione (GSH), an abundant tripeptidyl molecule, plays pivotal roles in protecting cells against oxidative stress-induced cellular damage and in detoxifying xenobiotics and drug metabolism. ...Decreased GSH levels are associated with the common features of ag
Glutathione (GSH), an abundant tripeptidyl molecule, plays pivotal roles in protecting cells against oxidative stress-induced cellula
Metformin alleviates human cellular aging by upregulating the endoplasmic reticulum glutathione peroxidase 7.
Fang J, Yang J, Wu X, Zhang G, Li T, Wang X, Zhang H, Wang CC, Liu GH, Wang L. Fang J, et al. Aging Cell. 2018 Aug;17(4):e12765. doi: 10.1111/acel.12765. Epub 2018 Apr 16. Aging Cell. 2018. PMID: 29659168 Free PMC article.
We report that a low dose of metformin upregulates the endoplasmic reticulum-localized glutathione peroxidase 7 (GPx7). GP×7 expression levels are decreased in senescent human cells, and GPx7 depletion results in premature cellular senescence. ...Moreover, th …
We report that a low dose of metformin upregulates the endoplasmic reticulum-localized glutathione peroxidase 7 (GPx7). GP×7 expressi …
The anti-ageing hormone klotho induces Nrf2-mediated antioxidant defences in human aortic smooth muscle cells.
Maltese G, Psefteli PM, Rizzo B, Srivastava S, Gnudi L, Mann GE, Siow RC. Maltese G, et al. J Cell Mol Med. 2017 Mar;21(3):621-627. doi: 10.1111/jcmm.12996. Epub 2016 Oct 3. J Cell Mol Med. 2017. PMID: 27696667 Free PMC article.
AngII contributes to vascular ageing and atherogenesis by enhancing VSMC oxidative stress, senescence and apoptosis. This study demonstrates that soluble klotho (1 nM, 24 hrs) significantly induces expression of Nrf2 and the antioxidant enzymes haeme oxygenase (HO-1) and p …
AngII contributes to vascular ageing and atherogenesis by enhancing VSMC oxidative stress, senescence and apoptosis. This study demon …
Glutathione and glutathione derivatives in immunotherapy.
Fraternale A, Brundu S, Magnani M. Fraternale A, et al. Biol Chem. 2017 Feb 1;398(2):261-275. doi: 10.1515/hsz-2016-0202. Biol Chem. 2017. PMID: 27514076 Review.
Reduced glutathione (GSH) is the most prevalent non-protein thiol in animal cells. Its de novo and salvage synthesis serves to maintain a reduced cellular environment, which is important for several cellular functions. Altered intracellular GSH levels are observed i …
Reduced glutathione (GSH) is the most prevalent non-protein thiol in animal cells. Its de novo and salvage synthesis serves to mainta …
Selenium, aging and aging-related diseases.
Cai Z, Zhang J, Li H. Cai Z, et al. Aging Clin Exp Res. 2019 Aug;31(8):1035-1047. doi: 10.1007/s40520-018-1086-7. Epub 2018 Dec 3. Aging Clin Exp Res. 2019. PMID: 30511318 Review.
Selenoproteins (glutathione peroxidase, thioredoxin reductase, methionine sulfoxide reductase1 and endoplasmic reticulum-selenoproteins, etc.) have antioxidant effects and are involved in regulating antioxidant activities. ...It is believed that a low level of selen …
Selenoproteins (glutathione peroxidase, thioredoxin reductase, methionine sulfoxide reductase1 and endoplasmic reticulum-selenoprotei …
Quantitative real-time imaging of glutathione.
Jiang X, Chen J, Bajić A, Zhang C, Song X, Carroll SL, Cai ZL, Tang M, Xue M, Cheng N, Schaaf CP, Li F, MacKenzie KR, Ferreon ACM, Xia F, Wang MC, Maletić-Savatić M, Wang J. Jiang X, et al. Nat Commun. 2017 Jul 13;8:16087. doi: 10.1038/ncomms16087. Nat Commun. 2017. PMID: 28703127 Free PMC article.
RT is thus a versatile tool that can be used for both confocal microscopy and flow cytometry based high-throughput quantification of glutathione levels in single cells. We envision that this new glutathione probe will enable opportunities to study glutathi
RT is thus a versatile tool that can be used for both confocal microscopy and flow cytometry based high-throughput quantification of glut
Ketone bodies mimic the life span extending properties of caloric restriction.
Veech RL, Bradshaw PC, Clarke K, Curtis W, Pawlosky R, King MT. Veech RL, et al. IUBMB Life. 2017 May;69(5):305-314. doi: 10.1002/iub.1627. Epub 2017 Apr 3. IUBMB Life. 2017. PMID: 28371201 Free article. Review.
In the nucleus, FOXO proteins increase the transcription of genes encoding antioxidant enzymes, including superoxide dismutase 2, catalase, glutathione peroxidase, and hundreds of other genes. ...We hypothesize that increasing the levels of ketone bodies will also e …
In the nucleus, FOXO proteins increase the transcription of genes encoding antioxidant enzymes, including superoxide dismutase 2, catalase, …
Antioxidant therapies in attention deficit hyperactivity disorder.
Moghadas M, Essa MM, Ba-Omar T, Al-Shehi A, Qoronfleh MW, Eltayeb EA, Guillemin GJ, Manivasagam T, Justin-Thenmozhi A, Al-Bulushi BS, Al-Adawi S, Edalatmanesh MA. Moghadas M, et al. Front Biosci (Landmark Ed). 2019 Jan 1;24:313-333. Front Biosci (Landmark Ed). 2019. PMID: 30468658 Review.
The pathogenesis of ADHD has so far remained enigmatic, however, there is some evidence suggesting critical association among ADHD and the level of oxidative stress which trigger cell membrane damage, changes in inner structure and function of proteins, as well as structur …
The pathogenesis of ADHD has so far remained enigmatic, however, there is some evidence suggesting critical association among ADHD and the …
Therapeutic approaches to modulating glutathione levels as a pharmacological strategy in Alzheimer's disease.
Peter C, Braidy N, Zarka M, Welch J, Bridge W. Peter C, et al. Curr Alzheimer Res. 2015;12(4):298-313. doi: 10.2174/1567205012666150302160308. Curr Alzheimer Res. 2015. PMID: 25731620 Review.
Accumulating evidence has suggested the involvement of oxidative stress in the pathogenesis of Alzheimer's disease (AD). The main endogenous antioxidant, glutathione (GSH), has been shown to decline with ageing and in several age-related degenerative diseases …
Accumulating evidence has suggested the involvement of oxidative stress in the pathogenesis of Alzheimer's disease (AD). The main end …
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