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Year Number of Results
2004 1
2010 1
2011 3
2012 3
2013 1
2014 1
2015 3
2016 4
2017 2
2018 4
2019 6
2020 3
2021 2
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30 results
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Physiological and pathological cardiac hypertrophy.
Shimizu I, Minamino T. Shimizu I, et al. J Mol Cell Cardiol. 2016 Aug;97:245-62. doi: 10.1016/j.yjmcc.2016.06.001. Epub 2016 Jun 2. J Mol Cell Cardiol. 2016. PMID: 27262674 Review.
The heart must continuously pump blood to supply the body with oxygen and nutrients. ...Pathological hypertrophy is associated with fibrosis, capillary rarefaction, increased production of pro-inflammatory cytokines, and cellular dysfunction (impairment of signal
The heart must continuously pump blood to supply the body with oxygen and nutrients. ...Pathological hypertrophy is associated …
Cellular and molecular mechanisms of muscle atrophy.
Bonaldo P, Sandri M. Bonaldo P, et al. Dis Model Mech. 2013 Jan;6(1):25-39. doi: 10.1242/dmm.010389. Dis Model Mech. 2013. PMID: 23268536 Free PMC article. Review.
Excessive loss of muscle mass is associated with poor prognosis in several diseases, including myopathies and muscular dystrophies, as well as in systemic disorders such as cancer, diabetes, sepsis and heart failure. Muscle loss also occurs during aging. In this pap …
Excessive loss of muscle mass is associated with poor prognosis in several diseases, including myopathies and muscular dystrophies, as well …
Glutathione metabolism and its implications for health.
Wu G, Fang YZ, Yang S, Lupton JR, Turner ND. Wu G, et al. J Nutr. 2004 Mar;134(3):489-92. doi: 10.1093/jn/134.3.489. J Nutr. 2004. PMID: 14988435 Review.
In addition, enteral or parenteral cystine, methionine, N-acetyl-cysteine, and L-2-oxothiazolidine-4-carboxylate are effective precursors of cysteine for tissue GSH synthesis. Glutathione plays important roles in antioxidant defense, nutrient metabolism, and regulation of …
In addition, enteral or parenteral cystine, methionine, N-acetyl-cysteine, and L-2-oxothiazolidine-4-carboxylate are effective precursors of …
Ageing induced vascular smooth muscle cell senescence in atherosclerosis.
Uryga AK, Bennett MR. Uryga AK, et al. J Physiol. 2016 Apr 15;594(8):2115-24. doi: 10.1113/JP270923. Epub 2015 Sep 16. J Physiol. 2016. PMID: 26174609 Free PMC article. Review.
Hallmarks of ageing include evidence of cell senescence, DNA damage (including telomere attrition), mitochondrial dysfunction, a pro-inflammatory secretory phenotype, defects in proteostasis, epigenetic changes, deregulated nutrient sensing, and exhaustion of …
Hallmarks of ageing include evidence of cell senescence, DNA damage (including telomere attrition), mitochondrial dysfunction, …
Genetic Targeting of Organ-Specific Blood Vessels.
Pu W, He L, Han X, Tian X, Li Y, Zhang H, Liu Q, Huang X, Zhang L, Wang QD, Yu Z, Yang X, Smart N, Zhou B. Pu W, et al. Circ Res. 2018 Jun 22;123(1):86-99. doi: 10.1161/CIRCRESAHA.118.312981. Epub 2018 May 15. Circ Res. 2018. PMID: 29764841 Free PMC article.
Applying this new system, we generated a coronary endothelial cell-specific Cre (CoEC-Cre) and a brain endothelial cell-specific Cre (BEC-Cre). Through lineage tracing, gene knockout and overexpression experiments, we demonstrated that CoEC-Cre and BEC-Cre efficient …
Applying this new system, we generated a coronary endothelial cell-specific Cre (CoEC-Cre) and a brain endothelial cell-specif …
The metabolic regulation of aging.
Finkel T. Finkel T. Nat Med. 2015 Dec;21(12):1416-23. doi: 10.1038/nm.3998. Nat Med. 2015. PMID: 26646498 Review.
Here we review the environmental and genetic manipulations that link cellular and organismal metabolism to aging. In particular, we explore how nutrients are sensed and how various intracellular energy nodes seem to coordinate distinct metabolic alterations linked t …
Here we review the environmental and genetic manipulations that link cellular and organismal metabolism to aging. In particular, we e …
Growth factors, nutrient signaling, and cardiovascular aging.
Fontana L, Vinciguerra M, Longo VD. Fontana L, et al. Circ Res. 2012 Apr 13;110(8):1139-50. doi: 10.1161/CIRCRESAHA.111.246470. Circ Res. 2012. PMID: 22499903 Free PMC article. Review.
Growth factors regulated by specific macronutrients have been shown to promote aging and accelerate mortality in the majority of the organisms studied. ...Here, we review the link between growth factors, cardiac function, and heart disease with focus on the cardiopr …
Growth factors regulated by specific macronutrients have been shown to promote aging and accelerate mortality in the majority of the …
Food Perception Primes Hepatic ER Homeostasis via Melanocortin-Dependent Control of mTOR Activation.
Brandt C, Nolte H, Henschke S, Engström Ruud L, Awazawa M, Morgan DA, Gabel P, Sprenger HG, Hess ME, Günther S, Langer T, Rahmouni K, Fenselau H, Krüger M, Brüning JC. Brandt C, et al. Cell. 2018 Nov 15;175(5):1321-1335.e20. doi: 10.1016/j.cell.2018.10.015. Cell. 2018. PMID: 30445039 Free PMC article.
Here we demonstrate that sensory food perception is sufficient to elicit early activation of hepatic mTOR signaling, Xbp1 splicing, increased expression of ER-stress genes, and phosphatidylcholine synthesis, which translate into a rapid morphological ER remodeling. These r …
Here we demonstrate that sensory food perception is sufficient to elicit early activation of hepatic mTOR signaling, Xbp1 splicing, i …
A MAFG-lncRNA axis links systemic nutrient abundance to hepatic glucose metabolism.
Pradas-Juni M, Hansmeier NR, Link JC, Schmidt E, Larsen BD, Klemm P, Meola N, Topel H, Loureiro R, Dhaouadi I, Kiefer CA, Schwarzer R, Khani S, Oliverio M, Awazawa M, Frommolt P, Heeren J, Scheja L, Heine M, Dieterich C, Büning H, Yang L, Cao H, Jesus DF, Kulkarni RN, Zevnik B, Tröder SE, Knippschild U, Edwards PA, Lee RG, Yamamoto M, Ulitsky I, Fernandez-Rebollo E, Vallim TQA, Kornfeld JW. Pradas-Juni M, et al. Nat Commun. 2020 Jan 31;11(1):644. doi: 10.1038/s41467-020-14323-y. Nat Commun. 2020. PMID: 32005828 Free PMC article.
Here we show that a high fraction of lncRNAs, but not protein-coding mRNAs, are repressed during diet-induced obesity (DIO) and refeeding, whilst nutrient deprivation induced lncRNAs in mouse liver. Similarly, lncRNAs are lost in diabetic humans. LncRNA promoter analyses, …
Here we show that a high fraction of lncRNAs, but not protein-coding mRNAs, are repressed during diet-induced obesity (DIO) and refeeding, w …
TOR Signaling Pathway in Cardiac Aging and Heart Failure.
Daneshgar N, Rabinovitch PS, Dai DF. Daneshgar N, et al. Biomolecules. 2021 Jan 27;11(2):168. doi: 10.3390/biom11020168. Biomolecules. 2021. PMID: 33513917 Free PMC article. Review.
Mechanistic Target of Rapamycin (mTOR) signaling is a key regulator of cellular metabolism, integrating nutrient sensing with cell growth. ...In this review, we highlight recent advances of the impact of mTOR complex 1 pathway and its regulators on aging
Mechanistic Target of Rapamycin (mTOR) signaling is a key regulator of cellular metabolism, integrating nutrient sensing with …
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