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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1960 1
1961 1
1962 2
1963 2
1964 5
1965 8
1966 1
1967 5
1968 8
1969 5
1970 10
1971 6
1972 6
1973 5
1974 14
1975 14
1976 13
1977 17
1978 14
1979 15
1980 21
1981 26
1982 31
1983 32
1984 37
1985 36
1986 41
1987 36
1988 47
1989 51
1990 66
1991 68
1992 73
1993 64
1994 58
1995 88
1996 86
1997 77
1998 91
1999 79
2000 96
2001 107
2002 113
2003 109
2004 132
2005 163
2006 182
2007 184
2008 198
2009 178
2010 220
2011 191
2012 225
2013 262
2014 260
2015 247
2016 288
2017 255
2018 289
2019 281
2020 326
2021 283
2022 309
2023 258
2024 235
2025 1

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5,979 results

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Page 1
Glutathione in Brain Disorders and Aging.
Iskusnykh IY, Zakharova AA, Pathak D. Iskusnykh IY, et al. Molecules. 2022 Jan 5;27(1):324. doi: 10.3390/molecules27010324. Molecules. 2022. PMID: 35011559 Free PMC article. Review.
However, many metabolic pathways involve oxidization of glutathione, resulting in an imbalance in cellular homeostasis. Impairment of glutathione function in the brain is linked to loss of neurons during the aging process or as the result of neurological dise …
However, many metabolic pathways involve oxidization of glutathione, resulting in an imbalance in cellular homeostasis. Impairment of …
Glutathione as a mediator of cartilage oxidative stress resistance and resilience during aging and osteoarthritis.
Zhu S, Makosa D, Miller B, Griffin TM. Zhu S, et al. Connect Tissue Res. 2020 Jan;61(1):34-47. doi: 10.1080/03008207.2019.1665035. Epub 2019 Sep 15. Connect Tissue Res. 2020. PMID: 31522568 Free PMC article. Review.
The purpose of this article was to review and experimentally evaluate oxidative stress resistance and resilience concepts in cartilage using glutathione redox homeostasis as an example. This framework may help identify novel approaches for promoting chondrocyte homeostasis …
The purpose of this article was to review and experimentally evaluate oxidative stress resistance and resilience concepts in cartilage using …
Application of Glutathione as Anti-Oxidative and Anti-Aging Drugs.
Homma T, Fujii J. Homma T, et al. Curr Drug Metab. 2015;16(7):560-71. doi: 10.2174/1389200216666151015114515. Curr Drug Metab. 2015. PMID: 26467067 Review.
Glutathione (GSH), an abundant tripeptidyl molecule, plays pivotal roles in protecting cells against oxidative stress-induced cellular damage and in detoxifying xenobiotics and drug metabolism. ...Decreased GSH levels are associated with the common features of aging …
Glutathione (GSH), an abundant tripeptidyl molecule, plays pivotal roles in protecting cells against oxidative stress-induced cellula …
The effects of stress and aging on glutathione metabolism.
Maher P. Maher P. Ageing Res Rev. 2005 May;4(2):288-314. doi: 10.1016/j.arr.2005.02.005. Ageing Res Rev. 2005. PMID: 15936251 Review.
However, mild stress generally increases glutathione levels, often but not exclusively through effects on glutamate cysteine ligase, the rate-limiting enzyme for glutathione biosynthesis. ...In contrast, during aging, glutathione levels appear to decli …
However, mild stress generally increases glutathione levels, often but not exclusively through effects on glutamate cysteine ligase, …
Cochlear detoxification: Role of alpha class glutathione transferases in protection against oxidative lipid damage, ototoxicity, and cochlear aging.
Someya S, Kim MJ. Someya S, et al. Hear Res. 2021 Mar 15;402:108002. doi: 10.1016/j.heares.2020.108002. Epub 2020 May 28. Hear Res. 2021. PMID: 32600853 Free PMC article. Review.
The cellular detoxification system involves three phases of enzymatic detoxification. Of these, the glutathione transferase (GST) detoxification system converts a toxic compound into a less toxic form by conjugating the toxic compound to reduced glutathione by GST e …
The cellular detoxification system involves three phases of enzymatic detoxification. Of these, the glutathione transferase (GST) det …
Dietary thiols accelerate aging of C. elegans.
Gusarov I, Shamovsky I, Pani B, Gautier L, Eremina S, Katkova-Zhukotskaya O, Mironov A, Makarov AА, Nudler E. Gusarov I, et al. Nat Commun. 2021 Jul 15;12(1):4336. doi: 10.1038/s41467-021-24634-3. Nat Commun. 2021. PMID: 34267196 Free PMC article.
Glutathione (GSH) is the most abundant cellular antioxidant. As reactive oxygen species (ROS) are widely believed to promote aging and age-related diseases, and antioxidants can neutralize ROS, it follows that GSH and its precursor, N-acetyl cysteine (NAC), are amon …
Glutathione (GSH) is the most abundant cellular antioxidant. As reactive oxygen species (ROS) are widely believed to promote aging …
Glutathione and glutathione derivatives in immunotherapy.
Fraternale A, Brundu S, Magnani M. Fraternale A, et al. Biol Chem. 2017 Feb 1;398(2):261-275. doi: 10.1515/hsz-2016-0202. Biol Chem. 2017. PMID: 27514076 Review.
Reduced glutathione (GSH) is the most prevalent non-protein thiol in animal cells. Its de novo and salvage synthesis serves to maintain a reduced cellular environment, which is important for several cellular functions. Altered intracellular GSH levels are observed in a wid …
Reduced glutathione (GSH) is the most prevalent non-protein thiol in animal cells. Its de novo and salvage synthesis serves to mainta …
The role of glutathione in aging and cancer.
Richie JP Jr. Richie JP Jr. Exp Gerontol. 1992 Sep-Dec;27(5-6):615-26. doi: 10.1016/0531-5565(92)90015-r. Exp Gerontol. 1992. PMID: 1426093 Review.
The incidence and mortality rates from most cancers increase exponentially with age. It is likely that this aging phenomenon is partially due to specific changes that occur in the host resulting in an increased susceptibility to neoplasia. ...
The incidence and mortality rates from most cancers increase exponentially with age. It is likely that this aging phenomenon is parti …
New concept in nutrition for the maintenance of the aging eye redox regulation and therapeutic treatment of cataract disease; synergism of natural antioxidant imidazole-containing amino acid-based compounds, chaperone, and glutathione boosting agents: a systemic perspective on aging and longevity emerged from studies in humans.
Babizhayev MA. Babizhayev MA. Am J Ther. 2010 Jul-Aug;17(4):373-89. doi: 10.1097/MJT.0b013e3181d6b6c3. Am J Ther. 2010. PMID: 20463577 Review.
The aging eye seems to be at considerable risk from oxidative stress. This review outlines the potential role of the new nutritional strategy on redox balance in age-related eye diseases and detail how the synergism and interaction of imidazole-containing amino acid-based …
The aging eye seems to be at considerable risk from oxidative stress. This review outlines the potential role of the new nutritional …
5,979 results