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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1983 1
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1986 3
1987 1
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1990 4
1991 1
1994 3
1995 3
1996 3
1997 3
1998 1
1999 1
2000 3
2001 4
2002 7
2003 9
2004 4
2005 5
2006 7
2007 8
2008 7
2009 10
2010 5
2011 15
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238 results

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Page 1
Patulin and Xestoquinol are inhibitors of DNA topoisomerase 1.
Tumini E, Wellinger RE, Herrera-Moyano E, Navarro-Cansino P, García-Rubio M, Salas-Lloret D, Losada A, Muñoz-Alonso MJ, Gaillard H, Luna R, Aguilera A. Tumini E, et al. Among authors: aguilera a. Proc Natl Acad Sci U S A. 2025 Apr 29;122(17):e2421167122. doi: 10.1073/pnas.2421167122. Epub 2025 Apr 24. Proc Natl Acad Sci U S A. 2025. PMID: 40273104
Here, we provide genetic and molecular evidence supporting that Patulin and, to a lesser extent, Xestoquinol inhibit the first catalytic step of TOP1 in vitro, in yeast and in human cells. Particularly, Patulin prevents the accumulation of TOP1 cleavage complexes caused by …
Here, we provide genetic and molecular evidence supporting that Patulin and, to a lesser extent, Xestoquinol inhibit the first catalytic ste …
Histone variant H2A.Z is needed for efficient transcription-coupled NER and genome integrity in UV challenged yeast cells.
Gaillard H, Ciudad T, Aguilera A, Wellinger RE. Gaillard H, et al. Among authors: aguilera a. PLoS Genet. 2024 Sep 10;20(9):e1011300. doi: 10.1371/journal.pgen.1011300. eCollection 2024 Sep. PLoS Genet. 2024. PMID: 39255275 Free PMC article.
When located on the transcribed strand of active genes, these lesions are handled by transcription-coupled nucleotide excision repair (TC-NER), a yet incompletely understood NER sub-pathway. Here, using a genetic screen in the yeast Saccharomyces cerevisiae, …
When located on the transcribed strand of active genes, these lesions are handled by transcription-coupled nucleotide excision repair (TC-NE …
Expression of human RECQL5 in Saccharomyces cerevisiae causes transcription defects and transcription-associated genome instability.
Lafuente-Barquero J, Svejstrup JQ, Luna R, Aguilera A. Lafuente-Barquero J, et al. Among authors: aguilera a. Mol Genet Genomics. 2024 May 26;299(1):59. doi: 10.1007/s00438-024-02152-3. Mol Genet Genomics. 2024. PMID: 38796829 Free PMC article.
To expand our understanding of its function we expressed human RECQL5 in the yeast Saccharomyces cerevisiae, which does not have a RECQL5 ortholog. We found that RECQL5 expression leads to cell growth inhibition, increased genotoxic sensitivity and transcript …
To expand our understanding of its function we expressed human RECQL5 in the yeast Saccharomyces cerevisiae, which does …
238 results