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AHCC() Supplementation to Support Immune Function to Clear Persistent Human Papillomavirus Infections.
Smith JA, Gaikwad AA, Mathew L, Rech B, Faro JP, Lucci JA 3rd, Bai Y, Olsen RJ, Byrd TT. Smith JA, et al. Front Oncol. 2022 Jun 22;12:881902. doi: 10.3389/fonc.2022.881902. eCollection 2022. Front Oncol. 2022. PMID: 35814366 Free PMC article.
The AHCC supplement is a proprietary, standardized extract of cultured lentinula edodes mycelia (AHCC(), Amino Up, Ltd., Sapporo, Japan) that has been shown to have unique immune modulatory benefits. ...The duration of AHCC supplementation required beyond the …
The AHCC supplement is a proprietary, standardized extract of cultured lentinula edodes mycelia (AHCC(), Amino Up, Ltd., Sappo …
AHCC(), a Standardized Extract of Cultured Lentinula Edodes Mycelia, Promotes the Anti-Tumor Effect of Dual Immune Checkpoint Blockade Effect in Murine Colon Cancer.
Park HJ, Boo S, Park I, Shin MS, Takahashi T, Takanari J, Homma K, Kang I. Park HJ, et al. Front Immunol. 2022 Apr 20;13:875872. doi: 10.3389/fimmu.2022.875872. eCollection 2022. Front Immunol. 2022. PMID: 35514996 Free PMC article.
Here we investigated whether AHCC() promotes the therapeutic effect of immunotherapy in cancers. A combination of oral AHCC() and dual immune checkpoint blockade (DICB), including PD-1/CTLA-4 blockade, had reduced tumor growth and increased granzyme B and Ki-67 expr …
Here we investigated whether AHCC() promotes the therapeutic effect of immunotherapy in cancers. A combination of oral AHCC() …
The Effects of AHCC, a Standardized Extract of Cultured Lentinura edodes Mycelia, on Natural Killer and T Cells in Health and Disease: Reviews on Human and Animal Studies.
Shin MS, Park HJ, Maeda T, Nishioka H, Fujii H, Kang I. Shin MS, et al. J Immunol Res. 2019 Dec 20;2019:3758576. doi: 10.1155/2019/3758576. eCollection 2019. J Immunol Res. 2019. PMID: 31930148 Free PMC article. Review.
AHCC is reported to modulate the numbers and functions of immune cells including natural killer (NK) and T cells which play important roles in host defense, suggesting the possible implication of its supplementation in defending the host against infections and malignancies …
AHCC is reported to modulate the numbers and functions of immune cells including natural killer (NK) and T cells which play important …
AHCC inhibited hepatic stellate cells activation by regulation of cytoglobin induction via TLR2-SAPK/JNK pathway and collagen production via TLR4-NF-kappabeta pathway.
Urushima H, Matsubara T, Qiongya G, Daikoku A, Takayama M, Kadono C, Nakai H, Ikeya Y, Yuasa H, Ikeda K. Urushima H, et al. Am J Physiol Gastrointest Liver Physiol. 2024 Dec 1;327(6):G741-G753. doi: 10.1152/ajpgi.00134.2024. Epub 2024 Sep 24. Am J Physiol Gastrointest Liver Physiol. 2024. PMID: 39316687 Free PMC article.
In addition, AHCC suppressed collagen1a production by hepatic stellate cells through TLR4-NF-kappabeta pathway. AHCC was suggested to suppress hepatic fibrosis by inhibition of hepatic stellate cells activation. ...
In addition, AHCC suppressed collagen1a production by hepatic stellate cells through TLR4-NF-kappabeta pathway. AHCC was sugge …
Nucleotides and AHCC Enhance Th1 Responses In Vitro in Leishmania-Stimulated/Infected Murine Cells.
Dea-Ayuela MA, Segarra S, Serrano DR, Bolás-Fernández F. Dea-Ayuela MA, et al. Molecules. 2020 Aug 27;25(17):3918. doi: 10.3390/molecules25173918. Molecules. 2020. PMID: 32867338 Free PMC article.
The potential leishmanicidal activity of nucleotides and AHCC was assessed by quantifying nitric oxide (NO) production and replication of parasites. ...Lymphocyte proliferation was significantly enhanced by nucleotides, AHCC, and their combinations only after SLA st …
The potential leishmanicidal activity of nucleotides and AHCC was assessed by quantifying nitric oxide (NO) production and replicatio …
PD-1- CD45RA+ effector-memory CD8 T cells and CXCL10+ macrophages are associated with response to atezolizumab plus bevacizumab in advanced hepatocellular carcinoma.
Cappuyns S, Philips G, Vandecaveye V, Boeckx B, Schepers R, Van Brussel T, Arijs I, Mechels A, Bassez A, Lodi F, Jaekers J, Topal H, Topal B, Bricard O, Qian J, Van Cutsem E, Verslype C, Lambrechts D, Dekervel J. Cappuyns S, et al. Nat Commun. 2023 Nov 29;14(1):7825. doi: 10.1038/s41467-023-43381-1. Nat Commun. 2023. PMID: 38030622 Free PMC article.
The combination of atezolizumab plus bevacizumab (atezo/bev) has dramatically changed the treatment landscape of advanced HCC (aHCC), achieving durable responses in some patients. Using single-cell transcriptomics, we characterize the intra-tumoural and peripheral immune c …
The combination of atezolizumab plus bevacizumab (atezo/bev) has dramatically changed the treatment landscape of advanced HCC (aHCC), …
Oral Supplementation with AHCC(), a Standardized Extract of Cultured Lentinula edodes Mycelia, Enhances Host Resistance against SARS-CoV-2 Infection.
Singh A, Adam A, Rodriguez L, Peng BH, Wang B, Xie X, Shi PY, Homma K, Wang T. Singh A, et al. Pathogens. 2023 Apr 3;12(4):554. doi: 10.3390/pathogens12040554. Pathogens. 2023. PMID: 37111440 Free PMC article.
AHCC treatment also significantly reduced SARS-CoV-2-induced lethality in the K18-hACE2 mice. ...In AHCC-fed BALB/c mice, SARS-CoV-2 specific IgG responses were also enhanced. In summary, AHCC supplementation enhances host resistance against mild and severe C …
AHCC treatment also significantly reduced SARS-CoV-2-induced lethality in the K18-hACE2 mice. ...In AHCC-fed BALB/c mice, SARS …
Molecular Markers of Response to Anti-PD1 Therapy in Advanced Hepatocellular Carcinoma.
Haber PK, Castet F, Torres-Martin M, Andreu-Oller C, Puigvehí M, Miho M, Radu P, Dufour JF, Verslype C, Zimpel C, Marquardt JU, Galle PR, Vogel A, Bathon M, Meyer T, Labgaa I, Digklia A, Roberts LR, Mohamed Ali MA, Mínguez B, Citterio D, Mazzaferro V, Finkelmeier F, Trojan J, Özdirik B, Müller T, Schmelzle M, Bejjani A, Sung MW, Schwartz ME, Finn RS, Thung S, Villanueva A, Sia D, Llovet JM. Haber PK, et al. Gastroenterology. 2023 Jan;164(1):72-88.e18. doi: 10.1053/j.gastro.2022.09.005. Epub 2022 Sep 12. Gastroenterology. 2023. PMID: 36108710 Free article.
BACKGROUND & AIMS: Single-agent anti-PD1 checkpoint inhibitors convey outstanding clinical benefits in a small fraction (20%) of patients with advanced hepatocellular carcinoma (aHCC) but the molecular mechanisms determining response are unknown. To fill this gap, we h …
BACKGROUND & AIMS: Single-agent anti-PD1 checkpoint inhibitors convey outstanding clinical benefits in a small fraction (20%) of patient …
Effects of AHCC on Immune and Stress Responses in Healthy Individuals.
Takanari J, Sato A, Waki H, Miyazaki S, Uebaba K, Hisajima T. Takanari J, et al. J Evid Based Integr Med. 2018 Jan-Dec;23:2156587218756511. doi: 10.1177/2156587218756511. J Evid Based Integr Med. 2018. PMID: 29558822 Free PMC article.
AHCC is a functional food from the basidiomycete Lentinula edodes. We evaluated the effects of AHCC on subjects under different kinds of stress and at rest. ...In subjects with chronic mental stress, self-reported "initiation and maintenance of sleep" was significan …
AHCC is a functional food from the basidiomycete Lentinula edodes. We evaluated the effects of AHCC on subjects under differen …
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