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Autotaxin in Pathophysiology and Pulmonary Fibrosis.
Ninou I, Magkrioti C, Aidinis V. Ninou I, et al. Front Med (Lausanne). 2018 Jun 13;5:180. doi: 10.3389/fmed.2018.00180. eCollection 2018. Front Med (Lausanne). 2018. PMID: 29951481 Free PMC article. Review.
In this review, we focus on ectonucleotide pyrophosphatase-phosphodiesterase 2 (ENPP2), or as more widely known Autotaxin (ATX), a secreted lysophospholipase D (lysoPLD) largely responsible for extracellular lysophosphatidic acid (LPA) production. ...
In this review, we focus on ectonucleotide pyrophosphatase-phosphodiesterase 2 (ENPP2), or as more widely known Autotaxin (ATX), a se …
Autotaxin and chronic inflammatory diseases.
Magkrioti C, Galaris A, Kanellopoulou P, Stylianaki EA, Kaffe E, Aidinis V. Magkrioti C, et al. J Autoimmun. 2019 Nov;104:102327. doi: 10.1016/j.jaut.2019.102327. Epub 2019 Aug 28. J Autoimmun. 2019. PMID: 31471142 Review.
Autotaxin (ATX) is a secreted glycoprotein, widely present in biological fluids including blood. ...
Autotaxin (ATX) is a secreted glycoprotein, widely present in biological fluids including blood. ...
Structure-Based Discovery of Novel Chemical Classes of Autotaxin Inhibitors.
Magkrioti C, Kaffe E, Stylianaki EA, Sidahmet C, Melagraki G, Afantitis A, Matralis AN, Aidinis V. Magkrioti C, et al. Int J Mol Sci. 2020 Sep 23;21(19):7002. doi: 10.3390/ijms21197002. Int J Mol Sci. 2020. PMID: 32977539 Free PMC article.
Autotaxin (ATX) is a secreted glycoprotein, widely present in biological fluids, largely responsible for extracellular lysophosphatidic acid (LPA) production. ...
Autotaxin (ATX) is a secreted glycoprotein, widely present in biological fluids, largely responsible for extracellular lysophosphatid
Genetic deletion of Autotaxin from CD11b+ cells decreases the severity of experimental autoimmune encephalomyelitis.
Ninou I, Sevastou I, Magkrioti C, Kaffe E, Stamatakis G, Thivaios S, Panayotou G, Aoki J, Kollias G, Aidinis V. Ninou I, et al. PLoS One. 2020 Apr 2;15(4):e0226050. doi: 10.1371/journal.pone.0226050. eCollection 2020. PLoS One. 2020. PMID: 32240164 Free PMC article.
Autotaxin (ATX) is a secreted lysophospholipase D catalyzing the extracellular production of lysophosphatidic acid (LPA), a growth factor-like signaling lysophospholipid. ...
Autotaxin (ATX) is a secreted lysophospholipase D catalyzing the extracellular production of lysophosphatidic acid (LPA), a growth fa
The Autotaxin-Lysophosphatidic Acid Axis Promotes Lung Carcinogenesis.
Magkrioti C, Oikonomou N, Kaffe E, Mouratis MA, Xylourgidis N, Barbayianni I, Megadoukas P, Harokopos V, Valavanis C, Chun J, Kosma A, Stathopoulos GT, Bouros E, Bouros D, Syrigos K, Aidinis V. Magkrioti C, et al. Cancer Res. 2018 Jul 1;78(13):3634-3644. doi: 10.1158/0008-5472.CAN-17-3797. Epub 2018 May 3. Cancer Res. 2018. PMID: 29724718 Free article.
Pathogenesis and progression of lung cancer are governed by complex interactions between the environment and host genetic susceptibility, which is further modulated by genetic and epigenetic changes. Autotaxin (ATX, ENPP2) is a secreted glycoprotein that catalyzes the extr …
Pathogenesis and progression of lung cancer are governed by complex interactions between the environment and host genetic susceptibility, wh …
Autotaxin and Endotoxin-Induced Acute Lung Injury.
Mouratis MA, Magkrioti C, Oikonomou N, Katsifa A, Prestwich GD, Kaffe E, Aidinis V. Mouratis MA, et al. PLoS One. 2015 Jul 21;10(7):e0133619. doi: 10.1371/journal.pone.0133619. eCollection 2015. PLoS One. 2015. PMID: 26196781 Free PMC article.
Here, we report that LPS inhalation in mice results in increased bronchoalveolar lavage fluid (BALF) levels of Autotaxin (ATX, Enpp2), a lysophospholipase D largely responsible for the conversion of lysophosphatidylcholine (LPC) to lysophosphatidic acid (LPA) in biological …
Here, we report that LPS inhalation in mice results in increased bronchoalveolar lavage fluid (BALF) levels of Autotaxin (ATX, Enpp2) …
Hepatocyte autotaxin expression promotes liver fibrosis and cancer.
Kaffe E, Katsifa A, Xylourgidis N, Ninou I, Zannikou M, Harokopos V, Foka P, Dimitriadis A, Evangelou K, Moulas AN, Georgopoulou U, Gorgoulis VG, Dalekos GN, Aidinis V. Kaffe E, et al. Hepatology. 2017 Apr;65(4):1369-1383. doi: 10.1002/hep.28973. Epub 2017 Feb 7. Hepatology. 2017. PMID: 27981605
Autotaxin (ATX) is a secreted lysophospholipase D that catalyzes the production of lysophosphatidic acid (LPA), a pleiotropic growth-factor-like lysophospholipid. ...
Autotaxin (ATX) is a secreted lysophospholipase D that catalyzes the production of lysophosphatidic acid (LPA), a pleiotropic growth-
Autotaxin, a secreted lysophospholipase D, as a promising therapeutic target in chronic inflammation and cancer.
Barbayianni E, Kaffe E, Aidinis V, Kokotos G. Barbayianni E, et al. Prog Lipid Res. 2015 Apr;58:76-96. doi: 10.1016/j.plipres.2015.02.001. Epub 2015 Feb 20. Prog Lipid Res. 2015. PMID: 25704398 Review.
Autotaxin (ATX) is a member of the nucleotide pyrophosphatase/phosphodiesterase family of ectoenzymes that hydrolyzes phosphodiester bonds of various nucleotides. ...
Autotaxin (ATX) is a member of the nucleotide pyrophosphatase/phosphodiesterase family of ectoenzymes that hydrolyzes phosphodiester
Computer Aided Drug Design Approaches for Identification of Novel Autotaxin (ATX) Inhibitors.
Vrontaki E, Melagraki G, Kaffe E, Mavromoustakos T, Kokotos G, Aidinis V, Afantitis A. Vrontaki E, et al. Curr Med Chem. 2016;23(17):1708-24. doi: 10.2174/0929867323666160321122228. Curr Med Chem. 2016. PMID: 26997151 Review.
Autotaxin (ATX) has become an attractive target with a huge pharmacological and pharmacochemical interest in LPA-related diseases and to date many small organic molecules have been explored as potential ATX inhibitors. ...
Autotaxin (ATX) has become an attractive target with a huge pharmacological and pharmacochemical interest in LPA-related diseases and
Development and therapeutic potential of autotaxin small molecule inhibitors: From bench to advanced clinical trials.
Matralis AN, Afantitis A, Aidinis V. Matralis AN, et al. Med Res Rev. 2019 May;39(3):976-1013. doi: 10.1002/med.21551. Epub 2018 Nov 21. Med Res Rev. 2019. PMID: 30462853 Review.
Several years after its isolation from melanoma cells, an increasing body of experimental evidence has established the involvement of Autotaxin (ATX) in the pathogenesis of several diseases. ATX, an extracellular enzyme responsible for the hydrolysis of lysophosphatidylcho …
Several years after its isolation from melanoma cells, an increasing body of experimental evidence has established the involvement of Aut
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