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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1972 1
1973 1
1975 1
1979 2
1980 1
1981 2
1982 3
1983 6
1984 5
1985 4
1986 1
1987 3
1988 4
1989 11
1990 5
1991 10
1992 16
1993 23
1994 26
1995 25
1996 34
1997 29
1998 25
1999 20
2000 24
2001 28
2002 21
2003 21
2004 46
2005 20
2006 41
2007 34
2008 43
2009 33
2010 51
2011 45
2012 51
2013 56
2014 57
2015 49
2016 58
2017 43
2018 63
2019 48
2020 21
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1,021 results
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Page 1
The airway epithelium in asthma.
Lambrecht BN, Hammad H. Lambrecht BN, et al. Nat Med. 2012 May 4;18(5):684-92. doi: 10.1038/nm.2737. Nat Med. 2012. PMID: 22561832 Review.
The airway epithelium is considered an essential controller of inflammatory, immune and regenerative responses to allergens, viruses and environmental pollutants that contribute to asthma pathogenesis. ...Improved understanding of the epithelium's
The airway epithelium is considered an essential controller of inflammatory, immune and regenerative responses to allergens, …
Differentiated human airway organoids to assess infectivity of emerging influenza virus.
Zhou J, Li C, Sachs N, Chiu MC, Wong BH, Chu H, Poon VK, Wang D, Zhao X, Wen L, Song W, Yuan S, Wong KK, Chan JF, To KK, Chen H, Clevers H, Yuen KY. Zhou J, et al. Proc Natl Acad Sci U S A. 2018 Jun 26;115(26):6822-6827. doi: 10.1073/pnas.1806308115. Epub 2018 Jun 11. Proc Natl Acad Sci U S A. 2018. PMID: 29891677 Free PMC article.
Collectively, we developed differentiated human airway organoids which can morphologically and functionally simulate human airway epithelium. These differentiated airway organoids can be applied for rapid assessment of the infectivity of emerging respi …
Collectively, we developed differentiated human airway organoids which can morphologically and functionally simulate human airway
Coronaviruses and the human airway: a universal system for virus-host interaction studies.
Jonsdottir HR, Dijkman R. Jonsdottir HR, et al. Virol J. 2016 Feb 6;13:24. doi: 10.1186/s12985-016-0479-5. Virol J. 2016. PMID: 26852031 Free PMC article. Review.
To establish a link between the research conducted in animal models and humans, an organotypic human airway culture system, that recapitulates the human airway epithelium, has been developed. Currently, different cell culture systems are available to recapitu …
To establish a link between the research conducted in animal models and humans, an organotypic human airway culture system, that reca …
Influenza Virus with Increased pH of Hemagglutinin Activation Has Improved Replication in Cell Culture but at the Cost of Infectivity in Human Airway Epithelium.
Singanayagam A, Zambon M, Barclay WS. Singanayagam A, et al. J Virol. 2019 Aug 13;93(17):e00058-19. doi: 10.1128/JVI.00058-19. Print 2019 Sep 1. J Virol. 2019. PMID: 31189708 Free PMC article.
Conversely, in primary human airway epithelium cultured at the air-liquid interface, increased pH sensitivity attenuated multicycle viral replication by compromising virus survival in the extracellular microenvironment. ...Here, we demonstrate a delicate bala …
Conversely, in primary human airway epithelium cultured at the air-liquid interface, increased pH sensitivity attenuated multi …
Late therapeutic intervention with a respiratory syncytial virus L-protein polymerase inhibitor, PC786, on respiratory syncytial virus infection in human airway epithelium.
Brookes DW, Coates M, Allen H, Daly L, Constant S, Huang S, Hows M, Davis A, Cass L, Ayrton J, Knowles I, Strong P, Rapeport G, Ito K. Brookes DW, et al. Br J Pharmacol. 2018 Jun;175(12):2520-2534. doi: 10.1111/bph.14221. Epub 2018 May 2. Br J Pharmacol. 2018. PMID: 29579332 Free PMC article.
EXPERIMENTAL APPROACH: Air liquid interface-cultured bronchial or small airway epithelium was infected with RSVA2. PC786 was applied apically or basolaterally once daily following peak virus load on Day 3 post inoculation. ...The effects of PC786 were also co …
EXPERIMENTAL APPROACH: Air liquid interface-cultured bronchial or small airway epithelium was infected with RSVA2. PC786 was a …
Differential antiviral activities of respiratory syncytial virus (RSV) inhibitors in human airway epithelium.
Mirabelli C, Jaspers M, Boon M, Jorissen M, Koukni M, Bardiot D, Chaltin P, Marchand A, Neyts J, Jochmans D. Mirabelli C, et al. J Antimicrob Chemother. 2018 Jul 1;73(7):1823-1829. doi: 10.1093/jac/dky089. J Antimicrob Chemother. 2018. PMID: 29596680 Free PMC article.
OBJECTIVES: We report the use of reconstituted 3D human airway epithelium cells (HuAECs) of bronchial origin in an air-liquid interface to study respiratory syncytial virus (RSV) infection and to assess the efficacy of RSV inhibitors in (pre-)clinical develop …
OBJECTIVES: We report the use of reconstituted 3D human airway epithelium cells (HuAECs) of bronchial origin in an air-liquid …
Influenza virus-induced lung injury: pathogenesis and implications for treatment.
Herold S, Becker C, Ridge KM, Budinger GR. Herold S, et al. Eur Respir J. 2015 May;45(5):1463-78. doi: 10.1183/09031936.00186214. Epub 2015 Mar 18. Eur Respir J. 2015. PMID: 25792631 Free article. Review.
Influenza-mediated damage of the airway, alveolar epithelium and alveolar endothelium results from a combination of: 1) intrinsic viral pathogenicity, attributable to its tropism for host airway and alveolar epithelial cells; and 2) a robust host innate immun …
Influenza-mediated damage of the airway, alveolar epithelium and alveolar endothelium results from a combination of: 1) intrin …
SARS-CoV replication and pathogenesis in an in vitro model of the human conducting airway epithelium.
Sims AC, Burkett SE, Yount B, Pickles RJ. Sims AC, et al. Version 2. Virus Res. 2008 Apr;133(1):33-44. doi: 10.1016/j.virusres.2007.03.013. Epub 2007 Apr 23. Virus Res. 2008. PMID: 17451829 Free PMC article. Review.
The second model system, derived from primary cells isolated from human airway epithelium and grown on Transwells, form a pseudostratified mucociliary epithelium that recapitulates the morphological and physiological features of the human conducting airway
The second model system, derived from primary cells isolated from human airway epithelium and grown on Transwells, form a pseu …
Antiviral drug screening by assessing epithelial functions and innate immune responses in human 3D airway epithelium model.
Boda B, Benaoudia S, Huang S, Bonfante R, Wiszniewski L, Tseligka ED, Tapparel C, Constant S. Boda B, et al. Antiviral Res. 2018 Aug;156:72-79. doi: 10.1016/j.antiviral.2018.06.007. Epub 2018 Jun 8. Antiviral Res. 2018. PMID: 29890184 Free PMC article.
MucilAir™, a human standardized air-liquid interface 3D airway epithelial culture holds in vitro specific mechanisms to counter invaders comparable to the in vivo situation, such as mucus production, mucociliary clearance, and secretion of defensive molecules. ...Fully dif …
MucilAir™, a human standardized air-liquid interface 3D airway epithelial culture holds in vitro specific mechanisms to counter invad …
Respiratory syncytial virus interaction with human airway epithelium.
Villenave R, Shields MD, Power UF. Villenave R, et al. Trends Microbiol. 2013 May;21(5):238-44. doi: 10.1016/j.tim.2013.02.004. Epub 2013 Mar 22. Trends Microbiol. 2013. PMID: 23523320 Review.
Although respiratory syncytial virus (RSV) is a major human respiratory pathogen, our knowledge of how it causes disease in humans is limited. ...Here we review the interaction of RSV with WD-PAEC cultures, the authenticity of the RSV-WD-PAEC models relative to RSV infecti …
Although respiratory syncytial virus (RSV) is a major human respiratory pathogen, our knowledge of how it causes disease in humans is …
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