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Page 1
New insights into apoptosome structure and function.
Dorstyn L, Akey CW, Kumar S. Dorstyn L, et al. Among authors: akey cw. Cell Death Differ. 2018 Jul;25(7):1194-1208. doi: 10.1038/s41418-017-0025-z. Epub 2018 May 15. Cell Death Differ. 2018. PMID: 29765111 Free PMC article. Review.
The apoptosome is a platform that activates apical procaspases in response to intrinsic cell death signals. ...Ribbon diagrams of the active CED-4, Dark and Apaf-1 apoptosomes are shown (right column)....
The apoptosome is a platform that activates apical procaspases in response to intrinsic cell death signals. ...Ribbon diagrams of the …
Oxidized or Reduced Cytochrome c and Axial Ligand Variants All Form the Apoptosome in Vitro.
Mendez DL, Akey IV, Akey CW, Kranz RG. Mendez DL, et al. Among authors: akey cw. Biochemistry. 2017 Jun 6;56(22):2766-2769. doi: 10.1021/acs.biochem.7b00309. Epub 2017 May 19. Biochemistry. 2017. PMID: 28510448 Free PMC article.
In the cytosol, cyt c interacts stoichiometrically with apoptotic protease activating factor 1 (Apaf-1) and upon ATP binding induces formation of the heptameric apoptosome. It is not clear however what the redox state of cyt c is when it functions as the "active signal" fo …
In the cytosol, cyt c interacts stoichiometrically with apoptotic protease activating factor 1 (Apaf-1) and upon ATP binding induces formati …
A Near-Atomic Structure of the Dark Apoptosome Provides Insight into Assembly and Activation.
Cheng TC, Akey IV, Yuan S, Yu Z, Ludtke SJ, Akey CW. Cheng TC, et al. Among authors: akey cw. Structure. 2017 Jan 3;25(1):40-52. doi: 10.1016/j.str.2016.11.002. Epub 2016 Dec 1. Structure. 2017. PMID: 27916517 Free PMC article.
In Drosophila, the Apaf-1-related killer (Dark) forms an apoptosome that activates procaspases. To investigate function, we have determined a near-atomic structure of Dark double rings using cryo-electron microscopy. ...Interestingly, beta-propellers in V-shaped domains of …
In Drosophila, the Apaf-1-related killer (Dark) forms an apoptosome that activates procaspases. To investigate function, we have dete …
A near atomic structure of the active human apoptosome.
Cheng TC, Hong C, Akey IV, Yuan S, Akey CW. Cheng TC, et al. Among authors: akey cw. Elife. 2016 Oct 4;5:e17755. doi: 10.7554/eLife.17755. Elife. 2016. PMID: 27697150 Free PMC article.
In response to cell death signals, an active apoptosome is assembled from Apaf-1 and procaspase-9 (pc-9). Here we report a near atomic structure of the active human apoptosome determined by cryo-electron microscopy. ...This suggests a stoichiometry of one or at most …
In response to cell death signals, an active apoptosome is assembled from Apaf-1 and procaspase-9 (pc-9). Here we report a near atomi …
Tango7 directs cellular remodeling by the Drosophila apoptosome.
D'Brot A, Chen P, Vaishnav M, Yuan S, Akey CW, Abrams JM. D'Brot A, et al. Among authors: akey cw. Genes Dev. 2013 Aug 1;27(15):1650-5. doi: 10.1101/gad.219287.113. Genes Dev. 2013. PMID: 23913920 Free PMC article.
However, the determinants that specify whether the apoptosome acts to kill or remodel have yet to be identified. Here we report that Tango7 collaborates with the Drosophila apoptosome to drive a caspase-dependent remodeling process needed to resolve individual sperm …
However, the determinants that specify whether the apoptosome acts to kill or remodel have yet to be identified. Here we report that …
Apoptosome structure, assembly, and procaspase activation.
Yuan S, Akey CW. Yuan S, et al. Among authors: akey cw. Structure. 2013 Apr 2;21(4):501-15. doi: 10.1016/j.str.2013.02.024. Structure. 2013. PMID: 23561633 Free PMC article. Review.
Apaf-1-like molecules assemble into a ring-like platform known as the apoptosome. This cell death platform then activates procaspases in the intrinsic cell death pathway. ...These findings have now set the stage for further studies of this critical activation process on th …
Apaf-1-like molecules assemble into a ring-like platform known as the apoptosome. This cell death platform then activates procaspases …
Changes in Apaf-1 conformation that drive apoptosome assembly.
Yuan S, Topf M, Reubold TF, Eschenburg S, Akey CW. Yuan S, et al. Among authors: akey cw. Biochemistry. 2013 Apr 2;52(13):2319-27. doi: 10.1021/bi301721g. Epub 2013 Mar 22. Biochemistry. 2013. PMID: 23521171 Free PMC article.
Apoptosome assembly is highly regulated in the intrinsic cell death pathway. To better understand this step, we created an improved model of the human apoptosome using a crystal structure of full length Apaf-1 and a single particle, electron density map at ~9.5 A re …
Apoptosome assembly is highly regulated in the intrinsic cell death pathway. To better understand this step, we created an improved m …
The holo-apoptosome: activation of procaspase-9 and interactions with caspase-3.
Yuan S, Yu X, Asara JM, Heuser JE, Ludtke SJ, Akey CW. Yuan S, et al. Among authors: akey cw. Structure. 2011 Aug 10;19(8):1084-96. doi: 10.1016/j.str.2011.07.001. Structure. 2011. PMID: 21827945 Free PMC article.
Activation of procaspase-9 on the apoptosome is a pivotal step in the intrinsic cell death pathway. We now provide further evidence that caspase recruitment domains of pc-9 and Apaf-1 form a CARD-CARD disk that is flexibly tethered to the apoptosome. ...These bindin …
Activation of procaspase-9 on the apoptosome is a pivotal step in the intrinsic cell death pathway. We now provide further evidence t …
Structure of the Drosophila apoptosome at 6.9 a resolution.
Yuan S, Yu X, Topf M, Dorstyn L, Kumar S, Ludtke SJ, Akey CW. Yuan S, et al. Among authors: akey cw. Structure. 2011 Jan 12;19(1):128-40. doi: 10.1016/j.str.2010.10.009. Structure. 2011. PMID: 21220123 Free PMC article.
This Dark-Dronc complex cleaves DrICE efficiently; hence, a single ring represents the Drosophila apoptosome. We then determined the 3D structure of a double ring at 6.9 A resolution and created a model of the apoptosome. Subunit interactions in the Dark complex ar …
This Dark-Dronc complex cleaves DrICE efficiently; hence, a single ring represents the Drosophila apoptosome. We then determined the …
Structure of an apoptosome-procaspase-9 CARD complex.
Yuan S, Yu X, Topf M, Ludtke SJ, Wang X, Akey CW. Yuan S, et al. Among authors: akey cw. Structure. 2010 May 12;18(5):571-83. doi: 10.1016/j.str.2010.04.001. Structure. 2010. PMID: 20462491 Free PMC article.
Apaf-1 coassembles with cytochrome c to form the apoptosome, which then binds and activates procaspase-9 (pc-9). We removed pc-9 catalytic domains from the holoapoptosome by site-directed thrombinolysis. A structure of the resulting apoptosome-pc-9 CARD complex was …
Apaf-1 coassembles with cytochrome c to form the apoptosome, which then binds and activates procaspase-9 (pc-9). We removed pc-9 cata …
Three-dimensional structure of a double apoptosome formed by the Drosophila Apaf-1 related killer.
Yu X, Wang L, Acehan D, Wang X, Akey CW. Yu X, et al. Among authors: akey cw. J Mol Biol. 2006 Jan 20;355(3):577-89. doi: 10.1016/j.jmb.2005.10.040. Epub 2005 Nov 8. J Mol Biol. 2006. PMID: 16310803
The Drosophila Apaf-1 related killer (Dark) forms an apoptosome that activates Dronc, an apical procaspase in the intrinsic cell death pathway. ...This analysis shows that a single Dark ring and the Apaf-1 apoptosome share many key features. When taken together, the …
The Drosophila Apaf-1 related killer (Dark) forms an apoptosome that activates Dronc, an apical procaspase in the intrinsic cell deat …
A structure of the human apoptosome at 12.8 A resolution provides insights into this cell death platform.
Yu X, Acehan D, Ménétret JF, Booth CR, Ludtke SJ, Riedl SJ, Shi Y, Wang X, Akey CW. Yu X, et al. Among authors: akey cw. Structure. 2005 Nov;13(11):1725-35. doi: 10.1016/j.str.2005.09.006. Structure. 2005. PMID: 16271896 Free article.
Apaf-1 and cytochrome c coassemble in the presence of dATP to form the apoptosome. We have determined a structure of the apoptosome at 12.8 A resolution by using electron cryomicroscopy and single-particle methods. ...Thus, we found that seven caspase recruitment do …
Apaf-1 and cytochrome c coassemble in the presence of dATP to form the apoptosome. We have determined a structure of the apoptosom …
Three-dimensional structure of the apoptosome: implications for assembly, procaspase-9 binding, and activation.
Acehan D, Jiang X, Morgan DG, Heuser JE, Wang X, Akey CW. Acehan D, et al. Among authors: akey cw. Mol Cell. 2002 Feb;9(2):423-32. doi: 10.1016/s1097-2765(02)00442-2. Mol Cell. 2002. PMID: 11864614 Free article.
The apoptosome is an Apaf-1 cytochrome c complex that activates procaspase-9. The three-dimensional structure of the apoptosome has been determined at 27 A resolution, to reveal a wheel-like particle with 7-fold symmetry. Molecular modeling was used to identify the …
The apoptosome is an Apaf-1 cytochrome c complex that activates procaspase-9. The three-dimensional structure of the apoptosome …